Search Results - "Hubner, Nina C."

A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances by Hein, Marco Y., Hubner, Nina C., Poser, Ina, Cox, Jürgen, Nagaraj, Nagarjuna, Toyoda, Yusuke, Gak, Igor A., Weisswange, Ina, Mansfeld, Jörg, Buchholz, Frank, Hyman, Anthony A., Mann, Matthias

“…The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the…”
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Whole-Genome Bisulfite Sequencing of Two Distinct Interconvertible DNA Methylomes of Mouse Embryonic Stem Cells by Habibi, Ehsan, Brinkman, Arie B., Arand, Julia, Kroeze, Leonie I., Kerstens, Hindrik H.D., Matarese, Filomena, Lepikhov, Konstantin, Gut, Marta, Brun-Heath, Isabelle, Hubner, Nina C., Benedetti, Rosaria, Altucci, Lucia, Jansen, Joop H., Walter, Jörn, Gut, Ivo G., Marks, Hendrik, Stunnenberg, Hendrik G.

“…The use of two kinase inhibitors (2i) enables derivation of mouse embryonic stem cells (ESCs) in the pluripotent ground state. Using whole-genome bisulfite…”
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Extracting gene function from protein–protein interactions using Quantitative BAC InteraCtomics (QUBIC) by Hubner, Nina C., Mann, Matthias

“…Large-scale proteomic screens are increasingly employed for placing genes into specific pathways. Therefore generic methods providing a physiological context…”
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Activin/nodal signaling and NANOG orchestrate human embryonic stem cell fate decisions by controlling the H3K4me3 chromatin mark by Bertero, Alessandro, Madrigal, Pedro, Galli, Antonella, Hubner, Nina C, Moreno, Inmaculada, Burks, Deborah, Brown, Stephanie, Pedersen, Roger A, Gaffney, Daniel, Mendjan, Sasha, Pauklin, Siim, Vallier, Ludovic

“…Stem cells can self-renew and differentiate into multiple cell types. These characteristics are maintained by the combination of specific signaling pathways…”
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Comprehensive mass-spectrometry-based proteome quantification of haploid versus diploid yeast by de Godoy, Lyris M.F, Olsen, Jesper V, Cox, Jurgen, Nielsen, Michael L, Hubner, Nina C, Frohlich, Florian, Walther, Tobias C, Mann, Matthias

“…Mass spectrometry is a powerful technology for the analysis of large numbers of endogenous proteins. However, the analytical challenges associated with…”
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High confidence determination of specific protein–protein interactions using quantitative mass spectrometry by Vermeulen, Michiel, Hubner, Nina C, Mann, Matthias

“…In recent years, interactions between proteins have successfully been determined by mass spectrometry. A limitation of this technology has been the need for…”
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Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) and Proteome Quantitation of Mouse Embryonic Stem Cells to a Depth of 5,111 Proteins by Graumann, Johannes, Hubner, Nina C., Kim, Jeong Beom, Ko, Kinarm, Moser, Markus, Kumar, Chanchal, Cox, Jürgen, Schöler, Hans, Mann, Matthias

“…Embryonic stem (ES) cells are pluripotent cells isolated from mammalian preimplantation embryos. They are capable of differentiating into all cell types and…”
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A covalent and cleavable antibody-DNA conjugation strategy for sensitive protein detection via immuno-PCR by van Buggenum, Jessie A. G. L., Gerlach, Jan P., Eising, Selma, Schoonen, Lise, van Eijl, Roderick A. P. M., Tanis, Sabine E. J., Hogeweg, Mark, Hubner, Nina C., van Hest, Jan C., Bonger, Kimberly M., Mulder, Klaas W.

“…Immuno-PCR combines specific antibody-based protein detection with the sensitivity of PCR-based quantification through the use of antibody-DNA conjugates. The…”
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RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity by Nitzsche, Anja, Paszkowski-Rogacz, Maciej, Matarese, Filomena, Janssen-Megens, Eva M, Hubner, Nina C, Schulz, Herbert, de Vries, Ingrid, Ding, Li, Huebner, Norbert, Mann, Matthias, Stunnenberg, Hendrik G, Buchholz, Frank

“…For self-renewal, embryonic stem cells (ESCs) require the expression of specific transcription factors accompanied by a particular chromosome organization to…”
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Epigenetic Repression of Androgen Receptor Transcription in Mutation-Negative Androgen Insensitivity Syndrome (AIS Type II) by Hornig, Nadine C, Rodens, Pascal, Dörr, Helmuth, Hubner, Nina C, Kulle, Alexandra E, Schweikert, Hans-Udo, Welzel, Maik, Bens, Susanne, Hiort, Olaf, Werner, Ralf, Gonzalves, Susanne, Eckstein, Anne Katrin, Cools, Martine, Verrijn-Stuart, Annemarie, Stunnenberg, Hendrik G, Siebert, Reiner, Ammerpohl, Ole, Holterhus, Paul-Martin

“…Inactivating mutations within the AR gene are present in only ~40% of individuals with clinically and hormonally diagnosed androgen insensitivity syndrome…”
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A Quantitative Proteomics Tool To Identify DNA–Protein Interactions in Primary Cells or Blood by Hubner, Nina C, Nguyen, Luan N, Hornig, Nadine C, Stunnenberg, Hendrik G

“…Interactions between transcription factors and genomic DNA, and in particular their impact on disease and cell fate, have been extensively studied on a global…”
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The Vertebrate Mitotic Checkpoint Protein BUBR1 Is an Unusual Pseudokinase by Suijkerbuijk, Saskia J.E., van Dam, Teunis J.P., Karagöz, G. Elif, von Castelmur, Eleonore, Hubner, Nina C., Duarte, Afonso M.S., Vleugel, Mathijs, Perrakis, Anastassis, Rüdiger, Stefan G.D., Snel, Berend, Kops, Geert J.P.L.

“…Chromosomal stability is safeguarded by a mitotic checkpoint, of which BUB1 and Mad3/BUBR1 are core components. These paralogs have similar, but not identical,…”
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The non-coding variant rs1800734 enhances DCLK3 expression through long-range interaction and promotes colorectal cancer progression by Liu, Ning Qing, ter Huurne, Menno, Nguyen, Luan N., Peng, Tianran, Wang, Shuang-Yin, Studd, James B., Joshi, Onkar, Ongen, Halit, Bramsen, Jesper B, Yan, Jian, Andersen, Claus L., Taipale, Jussi, Dermitzakis, Emmanouil T., Houlston, Richard S., Hubner, Nina C., Stunnenberg, Hendrik G.

“…Genome-wide association studies have identified a great number of non-coding risk variants for colorectal cancer (CRC). To date, the majority of these variants…”
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genome-wide screen for genes affecting eisosomes reveals Nce102 function in sphingolipid signaling by Fröhlich, Florian, Moreira, Karen, Aguilar, Pablo S, Hubner, Nina C, Mann, Matthias, Walter, Peter, Walther, Tobias C

“…The protein and lipid composition of eukaryotic plasma membranes is highly dynamic and regulated according to need. The sphingolipid-responsive Pkh kinases are…”
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The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis Program in t(8;21) AMLs by Mandoli, Amit, Singh, Abhishek A., Prange, Koen H.M., Tijchon, Esther, Oerlemans, Marjolein, Dirks, Rene, Ter Huurne, Menno, Wierenga, Albertus T.J., Janssen-Megens, Eva M., Berentsen, Kim, Sharifi, Nilofar, Kim, Bowon, Matarese, Filomena, Nguyen, Luan N., Hubner, Nina C., Rao, Nagesha A., van den Akker, Emile, Altucci, Lucia, Vellenga, Edo, Stunnenberg, Hendrik G., Martens, Joost H.A.

“…The t(8;21) acute myeloid leukemia (AML)-associated oncoprotein AML1-ETO disrupts normal hematopoietic differentiation. Here, we have investigated its effects…”
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A Polymorphic Enhancer near GREM1 Influences Bowel Cancer Risk through Differential CDX2 and TCF7L2 Binding by Lewis, Annabelle, Freeman-Mills, Luke, de la Calle-Mustienes, Elisa, Giráldez-Pérez, Rosa María, Davis, Hayley, Jaeger, Emma, Becker, Martin, Hubner, Nina C., Nguyen, Luan N., Zeron-Medina, Jorge, Bond, Gareth, Stunnenberg, Hendrik G., Carvajal, Jaime J., Gomez-Skarmeta, Jose Luis, Leedham, Simon, Tomlinson, Ian

“…A rare germline duplication upstream of the bone morphogenetic protein antagonist GREM1 causes a Mendelian-dominant predisposition to colorectal cancer (CRC)…”
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The SMAD2/3 interactome reveals that TGFβ controls m 6 A mRNA methylation in pluripotency by Bertero, Alessandro, Brown, Stephanie, Madrigal, Pedro, Osnato, Anna, Ortmann, Daniel, Yiangou, Loukia, Kadiwala, Juned, Hubner, Nina C, de Los Mozos, Igor Ruiz, Sadée, Christoph, Lenaerts, An-Sofie, Nakanoh, Shota, Grandy, Rodrigo, Farnell, Edward, Ule, Jernej, Stunnenberg, Hendrik G, Mendjan, Sasha, Vallier, Ludovic

“…The TGFβ pathway has essential roles in embryonic development, organ homeostasis, tissue repair and disease. These diverse effects are mediated through the…”
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How Much Peptide Sequence Information Is Contained in Ion Trap Tandem Mass Spectra? by Cox, Jürgen, Hubner, Nina C., Mann, Matthias

“…Matching peptide tandem mass spectra to their cognate amino acid sequences in databases is a key step in proteomics. It is usually performed by assigning a…”
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Peptide separation with immobilized pI strips is an attractive alternative to in-gel protein digestion for proteome analysis by Hubner, Nina C, Ren, Shubin, Mann, Matthias

“…Complex protein mixtures have traditionally been separated by 2-DE. Görg introduced IPGs as the first dimension of protein separation. In recent years,…”
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Quantitative proteomics combined with BAC TransgeneOmics reveals in vivo protein interactions by Hubner, Nina C, Bird, Alexander W, Cox, Jürgen, Splettstoesser, Bianca, Bandilla, Peter, Poser, Ina, Hyman, Anthony, Mann, Matthias

“…Protein interactions are involved in all cellular processes. Their efficient and reliable characterization is therefore essential for understanding biological…”
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