Search Results - "Hubert, E."

The human microbiome by Blum, Hubert E.

“…Until recently, human microbiology was based on the identification of single microbes, such as bacteria, fungi and viruses, frequently isolated from patients…”
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Cancer stem cells in glioblastoma by Lathia, Justin D, Mack, Stephen C, Mulkearns-Hubert, Erin E, Valentim, Claudia L L, Rich, Jeremy N

“…Tissues with defined cellular hierarchies in development and homeostasis give rise to tumors with cellular hierarchies, suggesting that tumors recapitulate…”
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Hepatocellular carcinoma: therapy and prevention by Blum, Hubert E

“…Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. The major etiologies and risk factors for the development of HCC are well…”
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Pore Architecture and Connectivity in Gas Shale by King, Hubert E, Eberle, Aaron P. R, Walters, Clifford C, Kliewer, Chris E, Ertas, Deniz, Huynh, Chuong

“…The pore size distribution and architecture in gas shales were studied using a combination of small-angle neutron scattering (SANS), mercury injection…”
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Fritz von Weizsäcker 1960–2019: An exceptional physician-scientist by Thimme, Robert, Blum, Hubert E.

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Immunodominance and functional alterations of tumor‐associated antigen‐specific CD8+ T‐cell responses in hepatocellular carcinoma by Flecken, Tobias, Schmidt, Nathalie, Hild, Sandra, Gostick, Emma, Drognitz, Oliver, Zeiser, Robert, Schemmer, Peter, Bruns, Helge, Eiermann, Thomas, Price, David A., Blum, Hubert E., Neumann‐Haefelin, Christoph, Thimme, Robert

“…Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide with a poor prognosis and limited therapeutic options. To aid the development of…”
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Human Th17 cells express high levels of enzymatically active dipeptidylpeptidase IV (CD26) by Bengsch, Bertram, Seigel, Bianca, Flecken, Tobias, Wolanski, Julia, Blum, Hubert E, Thimme, Robert

“…Dipeptidylpeptidase IV (CD26) is a multifunctional ectoenzyme involved in T cell activation that has been implicated in autoimmune pathophysiology. Because…”
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Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation by Bengsch, Bertram, Seigel, Bianca, Ruhl, Marianne, Timm, Jörg, Kuntz, Martin, Blum, Hubert E, Pircher, Hanspeter, Thimme, Robert

“…Exhausted CD8+ T cell responses during chronic viral infections are defined by a complex expression pattern of inhibitory receptors. However, very little…”
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Hepatitis C virus infection and apoptosis by Fischer, Richard, Baumert, Thomas, Blum, Hubert-E

“…Apoptosis is central for the control and elimination of viral infections. In chronic hepatitis C virus (HCV) infection, enhanced hepatocyte apoptosis and…”
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Generation of covalently closed circular DNA of hepatitis B viruses via intracellular recycling is regulated in a virus specific manner by Köck, Josef, Rösler, Christine, Zhang, Jing-Jing, Blum, Hubert E, Nassal, Michael, Thoma, Christian

“…Persistence of hepatitis B virus (HBV) infection requires covalently closed circular (ccc)DNA formation and amplification, which can occur via intracellular…”
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Novel opioid antagonists for opioid-induced bowel dysfunction and postoperative ileus by Becker, Gerhild, Dr, Blum, Hubert E, Prof

“…Summary Peripherally acting μ-opioid receptor antagonists methylnaltrexone and alvimopan are a new class of drugs designed to reverse opioid-induced…”
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Cancer Stem Cell‐Secreted Macrophage Migration Inhibitory Factor Stimulates Myeloid Derived Suppressor Cell Function and Facilitates Glioblastoma Immune Evasion by Otvos, Balint, Silver, Daniel J., Mulkearns‐Hubert, Erin E., Alvarado, Alvaro G., Turaga, Soumya M., Sorensen, Mia D., Rayman, Patricia, Flavahan, William A, Hale, James S., Stoltz, Kevin, Sinyuk, Maksim, Wu, Qiulian, Jarrar, Awad, Kim, Sung‐Hak, Fox, Paul L., Nakano, Ichiro, Rich, Jeremy N., Ransohoff, Richard M., Finke, James, Kristensen, Bjarne W., Vogelbaum, Michael A., Lathia, Justin D.

“…Shifting the balance away from tumor‐mediated immune suppression toward tumor immune rejection is the conceptual foundation for a variety of immunotherapy…”
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History and Global Burden of Viral Hepatitis by Blum, Hubert E

“…Between 1963 and 1989, 5 hepatotropic viruses have been discovered that are the major causes of viral hepatitides worldwide: hepatitis A virus, hepatitis B…”
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Hepatitis C virus-induced hepatocarcinogenesis by Bartosch, Birke, Thimme, Robert, Blum, Hubert E, Zoulim, Fabien

“…Although there is strong evidence that hepatitis C virus (HCV) is one of the leading causes of hepatocellular carcinoma (HCC), there is still much to…”
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Glioblastoma Cancer Stem Cells Evade Innate Immune Suppression of Self-Renewal through Reduced TLR4 Expression by Alvarado, Alvaro G., Thiagarajan, Praveena S., Mulkearns-Hubert, Erin E., Silver, Daniel J., Hale, James S., Alban, Tyler J., Turaga, Soumya M., Jarrar, Awad, Reizes, Ofer, Longworth, Michelle S., Vogelbaum, Michael A., Lathia, Justin D.

“…Tumors contain hostile inflammatory signals generated by aberrant proliferation, necrosis, and hypoxia. These signals are sensed and acted upon acutely by the…”
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Cancer Connectors: Connexins, Gap Junctions, and Communication by Sinyuk, Maksim, Mulkearns-Hubert, Erin E, Reizes, Ofer, Lathia, Justin

“…Despite concerted clinical and research efforts, cancer is a leading cause of death worldwide. Surgery, radiation, and chemotherapy have remained the most…”
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Analysis of CD161 expression on human CD8⁺ T cells defines a distinct functional subset with tissue-homing properties by Billerbeck, Eva, Kang, Yu-Hoi, Walker, Lucy, Lockstone, Helen, Grafmueller, Stefanie, Fleming, Vicki, Flint, Jonathan, Willberg, Chris B, Bengsch, Bertram, Seigel, Bianca, Ramamurthy, Narayan, Zitzmann, Nicole, Barnes, Eleanor J, Thevanayagam, Jonarthan, Bhagwanani, Anisha, Leslie, Alasdair, Oo, Ye H, Kollnberger, Simon, Bowness, Paul, Drognitz, Oliver, Adams, David H, Blum, Hubert E, Thimme, Robert, Klenerman, Paul

“…CD8⁺ T lymphocytes play a key role in host defense, in particular against important persistent viruses, although the critical functional properties of such…”
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Targeted therapy for hepatocellular carcinoma by Blum, Hubert E, Spangenberg, Hans Christian, Thimme, Robert

“…Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. Treatment options for patients with advanced HCC are limited because of…”
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HBV life cycle and novel drug targets by Grimm, Daniel, Thimme, Robert, Blum, Hubert E.

“…With up to 400 million affected people worldwide, chronic hepatitis B virus (HBV) infection is still a major health care problem. During the last decade,…”
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Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C by Pestka, Jan M, Zeisel, Mirjam B, Bläser, Edith, Schürmann, Peter, Bartosch, Birke, Cosset, Francois-Loïc, Patel, Arvind H, Meisel, Helga, Baumert, Jens, Viazov, Sergei, Rispeter, Kay, Blum, Hubert E, Roggendorf, Michael, Baumert, Thomas F

“…In contrast to a detailed understanding of antiviral cellular immune responses, the impact of neutralizing antibodies for the resolution of acute hepatitis C…”
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