Molecular epidemiology of Legionnaires‘ disease in Israel

Molecular epidemiology of Legionnaires‘ disease in Israel

National surveillance of Legionnaires‘ disease (LD) is important to inform control measures and facilitate international networking for timely reporting. This study is the first to describe the molecular epidemiology of LD in Israel. Case notifications for 2006–2011, collated through mandatory repor...

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Bibliographic Details
Published in:Clinical microbiology and infection Vol. 20; no. 7; pp. 690 - 696
Main Authors: Moran-Gilad, J., Mentasti, M., Lazarovitch, T., Huberman, Z., Stocki, T., Sadik, C., Shahar, T., Anis, E., Valinsky, L., Harrison, T.G., Grotto, I.
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-07-2014
Elsevier Limited
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Female
Genotype
Humans
Infant
Israel - epidemiology
Legionella
Legionella pneumophila
Legionella pneumophila - classification
Legionella pneumophila - genetics
Legionella pneumophila - isolation & purification
Legionnaires' disease
Legionnaires' Disease - epidemiology
Legionnaires' Disease - microbiology
Male
Middle Aged
Molecular Epidemiology
Molecular Typing
Prevalence
Serogroup
Serotyping
typing
Young Adult
Israel
molecular epidemiology
typing
Legionella
Legionnaires‘ disease
Legionnaires' disease
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Summary:National surveillance of Legionnaires‘ disease (LD) is important to inform control measures and facilitate international networking for timely reporting. This study is the first to describe the molecular epidemiology of LD in Israel. Case notifications for 2006–2011, collated through mandatory reporting, were identified and demographic, clinical and laboratory data were extracted. Unrelated clinical and environmental Legionella pneumophila strains were characterized using standard procedures, Dresden panel of monoclonal antibodies and the ESCMID Study Group for Legionella Infections (ESGLI) Sequence-Based Typing scheme. In all, 294 cases were reported (crude incidence 0.67 cases/100 000; age-standardized incidence 1/100 000). LD epidemiological trends and features largely resembled those of the EU, except for a larger proportion of nosocomial cases. Of 28 clinical and 23 environmental strains analysed, 71.4% and 21.7% were serogroup (sg) 1 and the most common immunological subgroup was OLDA/Oxford (64%). Of the clinical strains, OLDA/Oxford, ST1 was the most common (43%) followed by Allentown/France, ST40 (14%). The unusual sg 3 ST338 was found in 17.4% of environmental strains. Novel STs were detected amongst 23.5% of strains. These findings warrant further molecular investigation. Molecular epidemiology data generated from neighbouring countries newly adopting the ESGLI typing scheme for L. pneumophila contribute to understanding of regional strain diversity.
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ISSN:1198-743X
1469-0691
DOI:10.1111/1469-0691.12425