Search Results - "Huber, Scot"

Why and how have drug discovery strategies in pharma changed? What are the new mindsets? by Mignani, Serge, Huber, Scot, Tomás, Helena, Rodrigues, João, Majoral, Jean-Pierre

“…•Economic, scientific and strategic challenges of the pharmaceutical industry are analyzed.•New approaches to increase the output of innovative medicine are…”
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Compound high-quality criteria: a new vision to guide the development of drugs, current situation by Mignani, Serge, Huber, Scot, Tomás, Helena, Rodrigues, João, Majoral, Jean-Pierre

“…•Guides improving attrition rate from hits to final medicines are analyzed.•HTS and fragment-based drug discovery approaches are detailed.•Exploration of the…”
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Compound high-quality criteria: a new vision to guide the development of drugs, current situation: Foundation by Mignani, Serge, Huber, Scot, Tomas, Helena, Rodrigues, Joao, Majoral, Jean-Pierre

“…For several decades, the pharmaceutical industry has suffered due to major issues such as reductions of the number of FDA approved drugs and biologics. Several…”
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Why and how have drug discovery strategies in pharma changed? What are the new mindsets?: Keynote by Mignani, Serge, Huber, Scot, Tomas, Helena, Rodrigues, Joao, Majoral, Jean-Pierre

“…In the pharmaceutical industry the long-term challenge of drug innovation is the key phrase throughout R&D that refers to increasing the output of original…”
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A means for stereocontrolled introduction of the C-2 oxygen substituent in functionalized cis-tricyclo[9.3.1.03,8]pentadecanones related to taxol by Paquette, Leo A, Huber, Scot K, Thompson, Richard C

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Spirocyclization bygem-dialkylation at carbonyl carbons. Total synthesis of 13-noraphidicolin by Huber, Scot Kevin

“…Studies directed at the total synthesis of 13-noraphid-icolin are described. Initial studies were aimed at the development of a vinylstannane- or…”
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