Search Results - "Huber, Kimberly"

Group 1 mGluR-Dependent Synaptic Long-Term Depression: Mechanisms and Implications for Circuitry and Disease by Lüscher, Christian, Huber, Kimberly M.

“…Many excitatory synapses express Group 1, or Gq coupled, metabotropic glutamate receptors (Gp1 mGluRs) at the periphery of their postsynaptic density…”
Get full text

Multiple Autism-Linked Genes Mediate Synapse Elimination via Proteasomal Degradation of a Synaptic Scaffold PSD-95 by Tsai, Nien-Pei, Wilkerson, Julia R., Guo, Weirui, Maksimova, Marina A., DeMartino, George N., Cowan, Christopher W., Huber, Kimberly M.

“…The activity-dependent transcription factor myocyte enhancer factor 2 (MEF2) induces excitatory synapse elimination in mouse neurons, which requires fragile X…”
Get full text

Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism by Huber, Kimberly M, Klann, Eric, Costa-Mattioli, Mauro, Zukin, R Suzanne

“…The mammalian target of rapamycin (mTOR) is a central regulator of a diverse array of cellular processes, including cell growth, proliferation, autophagy,…”
Get full text

Synaptic homeostasis: quality vs. quantity by Huber, Kimberly M.

“…Synaptic connections adapt homeostatically to changes in experience to maintain optimal circuit function. A study demonstrates that different forms of synaptic…”
Get full text

FMRP Control of Ribosome Translocation Promotes Chromatin Modifications and Alternative Splicing of Neuronal Genes Linked to Autism by Shah, Sneha, Molinaro, Gemma, Liu, Botao, Wang, Ruijia, Huber, Kimberly M., Richter, Joel D.

“…Silencing of FMR1 and loss of its gene product, FMRP, results in fragile X syndrome (FXS). FMRP binds brain mRNAs and inhibits polypeptide elongation. Using…”
Get full text

Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression by Niere, Farr, Wilkerson, Julia R, Huber, Kimberly M

“…Group 1 metabotropic glutamate receptor (mGluR)-stimulated protein synthesis and long-term synaptic depression (mGluR-LTD) are altered in the mouse model of…”
Get full text

Homer Interactions Are Necessary for Metabotropic Glutamate Receptor-Induced Long-Term Depression and Translational Activation by Ronesi, Jennifer A, Huber, Kimberly M

“…Group I metabotropic glutamate receptors (mGluRs) induce a form of long-term synaptic depression (mGluR-LTD) in area CA1 of the hippocampus that requires rapid…”
Get full text

Experience-Induced Arc/Arg3.1 Primes CA1 Pyramidal Neurons for Metabotropic Glutamate Receptor-Dependent Long-Term Synaptic Depression by Jakkamsetti, Vikram, Tsai, Nien-Pei, Gross, Christina, Molinaro, Gemma, Collins, Katie A., Nicoletti, Ferdinando, Wang, Kuan H., Osten, Pavel, Bassell, Gary J., Gibson, Jay R., Huber, Kimberly M.

“…A novel experience induces the Arc/Arg3.1 gene as well as plasticity of CA1 neural networks. To understand how these are linked, we briefly exposed GFP…”
Get full text

Imbalance of Neocortical Excitation and Inhibition and Altered UP States Reflect Network Hyperexcitability in the Mouse Model of Fragile X Syndrome by Gibson, Jay R, Bartley, Aundrea F, Hays, Seth A, Huber, Kimberly M

“…University of Texas Southwestern Medical Center, Department of Neuroscience, Dallas, Texas Submitted 8 July 2008; accepted in final form 4 September 2008…”
Get full text

Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons by Liu, Meng-Lu, Zang, Tong, Zou, Yuhua, Chang, Joshua C., Gibson, Jay R., Huber, Kimberly M., Zhang, Chun-Li

“…Cell fate can be reprogrammed by modifying intrinsic and extrinsic cues. Here we show that two small molecules (forskolin and dorsomorphin) enable the…”
Get full text

Elevated CaMKIIα and Hyperphosphorylation of Homer Mediate Circuit Dysfunction in a Fragile X Syndrome Mouse Model by Guo, Weirui, Ceolin, Laura, Collins, Katie A., Perroy, Julie, Huber, Kimberly M.

“…Abnormal metabotropic glutamate receptor 5 (mGluR5) function, as a result of disrupted scaffolding with its binding partner Homer, contributes to the…”
Get full text

The State of Synapses in Fragile X Syndrome by Pfeiffer, Brad E., Huber, Kimberly M.

“…Fragile X syndrome (FXS) is the most common inherited form of mental retardation and a leading genetic cause of autism. There is increasing evidence in both…”
Get full text

Protein translation in synaptic plasticity: mGluR-LTD, Fragile X by Waung, Maggie W, Huber, Kimberly M

“…Synaptically activated, rapid and dendritic synthesis of new proteins has long been proposed to mediate long-lasting changes at the synapse [Steward O, Schuman…”
Get full text

Roles for Arc in metabotropic glutamate receptor-dependent LTD and synapse elimination: Implications in health and disease by Wilkerson, Julia R., Albanesi, Joseph P., Huber, Kimberly M.

“…•MGluR1/5-induced dendritic synthesis of Arc causes LTD and synapse elimination.•Arc stimulates endocytosis of postsynaptic AMPA receptors and dynamin…”
Get full text

Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry by Hays, Seth A, Huber, Kimberly M, Gibson, Jay R

“…Despite the pronounced neurological deficits associated with mental retardation and autism, the degree to which neocortical circuit function is altered remains…”
Get full text

The mGluR theory of fragile X mental retardation by Bear, Mark F, Huber, Kimberly M, Warren, Stephen T

“…Many of the diverse functional consequences of activating group 1 metabotropic glutamate receptors require translation of pre-existing mRNA near synapses. One…”
Get full text

Local cortical circuit correlates of altered EEG in the mouse model of Fragile X syndrome by Goswami, Sonal, Cavalier, Sheridan, Sridhar, Vinay, Huber, Kimberly M., Gibson, Jay R.

“…Electroencephalogram (EEG) recordings in Fragile X syndrome (FXS) patients have revealed enhanced sensory responses, enhanced resting “gamma frequency”…”
Get full text

Rapid Translation of Arc/Arg3.1 Selectively Mediates mGluR-Dependent LTD through Persistent Increases in AMPAR Endocytosis Rate by Waung, Maggie W., Pfeiffer, Brad E., Nosyreva, Elena D., Ronesi, Jennifer A., Huber, Kimberly M.

“…Salient stimuli that modify behavior induce transcription of activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) and transport Arc mRNA into…”
Get full text

Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome by Hooshmandi, Mehdi, Sharma, Vijendra, Thörn Perez, Carolina, Sood, Rapita, Krimbacher, Konstanze, Wong, Calvin, Lister, Kevin C., Ureña Guzmán, Alba, Bartley, Trevor D., Rocha, Cecilia, Maussion, Gilles, Nadler, Emma, Roque, Patricia Margarita, Gantois, Ilse, Popic, Jelena, Lévesque, Maxime, Kaufman, Randal J., Avoli, Massimo, Sanz, Elisenda, Nader, Karim, Hagerman, Randi Jenssen, Durcan, Thomas M., Costa-Mattioli, Mauro, Prager-Khoutorsky, Masha, Lacaille, Jean-Claude, Martinez-Cerdeno, Veronica, Gibson, Jay R., Huber, Kimberly M., Sonenberg, Nahum, Gkogkas, Christos G., Khoutorsky, Arkady

“…Dysregulation of protein synthesis is one of the key mechanisms underlying autism spectrum disorder (ASD). However, the role of a major pathway controlling…”
Get full text

Developmental trajectory and sex differences in auditory processing in a PTEN-deletion model of autism spectrum disorders by Croom, Katilynne, Rumschlag, Jeffrey A., Molinaro, Gemma, Erickson, Michael A., Binder, Devin K., Huber, Kimberly M., Razak, Khaleel A.

“…Autism Spectrum Disorders (ASD) encompass a wide array of debilitating symptoms, including severe sensory deficits and abnormal language development. Sensory…”
Get full text