Search Results - "Huber, Irit"

Tissue Engineering of Vascularized Cardiac Muscle From Human Embryonic Stem Cells by Caspi, Oren, Lesman, Ayelet, Basevitch, Yaara, Gepstein, Amira, Arbel, Gil, Habib, Irit Huber Manhal, Gepstein, Lior, Levenberg, Shulamit

“…Transplantation of a tissue-engineered heart muscle represents a novel experimental therapeutic paradigm for myocardial diseases. However, this strategy has…”
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Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells by ZWI, Limor, CASPI, Oren, ARBEL, Gil, HUBER, Irit, GEPSTEIN, Amira, PARK, In-Hyun, GEPSTEIN, Lior

“…The ability to derive human induced pluripotent stem (hiPS) cell lines by reprogramming of adult fibroblasts with a set of transcription factors offers unique…”
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Transplantation of Human Embryonic Stem Cell-Derived Cardiomyocytes Improves Myocardial Performance in Infarcted Rat Hearts by Caspi, Oren, MD, Huber, Irit, PhD, Kehat, Izhak, MD, PhD, Habib, Manhal, MD, Arbel, Gil, MSc, Gepstein, Amira, PhD, Yankelson, Lior, MD, Aronson, Doron, MD, Beyar, Rafael, MD, PhD, Gepstein, Lior, MD, PhD

“…Transplantation of Human Embryonic Stem Cell-Derived Cardiomyocytes Improves Myocardial Performance in Infarcted Rat Hearts Oren Caspi, Irit Huber, Izhak…”
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Modeling of Catecholaminergic Polymorphic Ventricular Tachycardia With Patient-Specific Human-Induced Pluripotent Stem Cells by Itzhaki, Ilanit, PhD, Maizels, Leonid, BSc, Huber, Irit, PhD, Gepstein, Amira, PhD, Arbel, Gil, MSc, Caspi, Oren, MD, PhD, Miller, Liron, PhD, Belhassen, Bernard, MD, Nof, Eyal, MD, Glikson, Michael, MD, Gepstein, Lior, MD, PhD

“…Objectives The goal of this study was to establish a patient-specific human-induced pluripotent stem cells (hiPSCs) model of catecholaminergic polymorphic…”
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Calcium handling in human induced pluripotent stem cell derived cardiomyocytes by Itzhaki, Ilanit, Rapoport, Sophia, Huber, Irit, Mizrahi, Itzhak, Zwi-Dantsis, Limor, Arbel, Gil, Schiller, Jackie, Gepstein, Lior

“…The ability to establish human induced pluripotent stem cells (hiPSCs) by reprogramming of adult fibroblasts and to coax their differentiation into…”
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Monitoring Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Genetically Encoded Calcium and Voltage Fluorescent Reporters by Shinnawi, Rami, Huber, Irit, Maizels, Leonid, Shaheen, Naim, Gepstein, Amira, Arbel, Gil, Tijsen, Anke J., Gepstein, Lior

“…The advent of the human-induced pluripotent stem cell (hiPSC) technology has transformed biomedical research, providing new tools for human disease modeling,…”
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Identification and selection of cardiomyocytes during human embryonic stem cell differentiation by Huber, Irit, Itzhaki, Ilanit, Caspi, Oren, Arbel, Gil, Tzukerman, Maty, Gepstein, Amira, Habib, Manhal, Yankelson, Lior, Kehat, Izhak, Gepstein, Lior

“…Human embryonic stem cells (hESC) are pluripotent lines that can differentiate in vitro into cell derivatives of all three germ layers, including…”
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Electromechanical integration of cardiomyocytes derived from human embryonic stem cells by Gepstein, Lior, Kehat, Izhak, Khimovich, Leonid, Caspi, Oren, Gepstein, Amira, Shofti, Rona, Arbel, Gil, Huber, Irit, Satin, Jonathan, Itskovitz-Eldor, Joseph

“…Cell therapy is emerging as a promising strategy for myocardial repair. This approach is hampered, however, by the lack of sources for human cardiac tissue and…”
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Derivation and cardiomyocyte differentiation of induced pluripotent stem cells from heart failure patients by Zwi-Dantsis, Limor, Huber, Irit, Habib, Manhal, Winterstern, Aaron, Gepstein, Amira, Arbel, Gil, Gepstein, Lior

“…Myocardial cell replacement therapies are hampered by a paucity of sources for human cardiomyocytes and by the expected immune rejection of allogeneic cell…”
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Human Induced Pluripotent Stem Cell-Derived Cardiac Cell Sheets Expressing Genetically Encoded Voltage Indicator for Pharmacological and Arrhythmia Studies by Shaheen, Naim, Shiti, Assad, Huber, Irit, Shinnawi, Rami, Arbel, Gil, Gepstein, Amira, Setter, Noga, Goldfracht, Idit, Gruber, Amit, Chorna, Snizhanna V., Gepstein, Lior

“…Fulfilling the potential of human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes for studying conduction and arrhythmogenesis requires…”
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Patient-Specific Drug Screening Using a Human Induced Pluripotent Stem Cell Model of Catecholaminergic Polymorphic Ventricular Tachycardia Type 2 by Maizels, Leonid, Huber, Irit, Arbel, Gil, Tijsen, Anke J, Gepstein, Amira, Khoury, Asaad, Gepstein, Lior

“…BACKGROUND—Catecholaminergic polymorphic ventricular tachycardia type 2 (CPVT2) results from autosomal recessive CASQ2 mutations, causing abnormal Ca-handling…”
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In vitro electrophysiological drug testing using human embryonic stem cell derived cardiomyocytes by Caspi, Oren, Itzhaki, Ilanit, Kehat, Izhak, Gepstein, Amira, Arbel, Gil, Huber, Irit, Satin, Jonathan, Gepstein, Lior

“…Pro-arrhythmia (development of cardiac arrhythmias as a pharmacological side effect) has become the single most common cause of the withdrawal or restrictions…”
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Optogenetic Control of Human Induced Pluripotent Stem Cell-Derived Cardiac Tissue Models by Gruber, Amit, Edri, Oded, Glatstein, Shany, Goldfracht, Idit, Huber, Irit, Arbel, Gil, Gepstein, Amira, Chorna, Snizhanna, Gepstein, Lior

“…Background Optogenetics, using light-sensitive proteins, emerged as a unique experimental paradigm to modulate cardiac excitability. We aimed to develop…”
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shRNAs Targeting a Common KCNQ1 Variant Could Alleviate Long-QT1 Disease Severity by Inhibiting a Mutant Allele by Cócera-Ortega, Lucía, Wilders, Ronald, Kamps, Selina C, Fabrizi, Benedetta, Huber, Irit, van der Made, Ingeborg, van den Bout, Anouk, de Vries, Dylan K, Gepstein, Lior, Verkerk, Arie O, Pinto, Yigal M, Tijsen, Anke J

“…Long-QT syndrome type 1 (LQT1) is caused by mutations in . Patients heterozygous for such a mutation co-assemble both mutant and wild-type -encoded subunits…”
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In Vivo Assessment of the Electrophysiological Integration and Arrhythmogenic Risk of Myocardial Cell Transplantation Strategies by Gepstein, Lior, Ding, Chunhua, Rehemedula, Dolkun, Wilson, Emily E., Yankelson, Lior, Caspi, Oren, Gepstein, Amira, Huber, Irit, Olgin, Jeffery E.

“…Cell replacement strategies are promising interventions aiming to improve myocardial performance. Yet, the electrophysiological impact of these approaches has…”
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Optogenetic modulation of cardiac action potential properties may prevent arrhythmogenesis in short and long QT syndromes by Gruber, Amit, Edri, Oded, Huber, Irit, Arbel, Gil, Gepstein, Amira, Shiti, Assad, Shaheen, Naim, Chorna, Snizhana, Landesberg, Michal, Gepstein, Lior

“…Abnormal action potential (AP) properties, as occurs in long or short QT syndromes (LQTS and SQTS, respectively), can cause life-threatening arrhythmias…”
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Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyocytes by Satin, Jonathan, Kehat, Izhak, Caspi, Oren, Huber, Irit, Arbel, Gil, Itzhaki, Ilanit, Magyar, Janos, Schroder, Elizabeth A., Perlman, Ido, Gepstein, Lior

“…Human embryonic stem cell-derived cardiomyocytes (hES-CMs) are thought to recapitulate the embryonic development of heart cells. Given the exciting potential…”
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Characterization of the mechanism by which a nonsense variant in RYR2 leads to disordered calcium handling by Hopton, Claire, Tijsen, Anke J., Maizels, Leonid, Arbel, Gil, Gepstein, Amira, Bates, Nicola, Brown, Benjamin, Huber, Irit, Kimber, Susan J., Newman, William G., Venetucci, Luigi, Gepstein, Lior

“…Heterozygous missense variants of the cardiac ryanodine receptor gene (RYR2) cause catecholaminergic polymorphic ventricular tachycardia (CPVT). These missense…”
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Reprogramming of telomeric regions during the generation of human induced pluripotent stem cells and subsequent differentiation into fibroblast-like derivatives by Yehezkel, Shiran, Rebibo-Sabbah, Annie, Segev, Yardena, Tzukerman, Maty, Shaked, Rony, Huber, Irit, Gepstein, Lior, Skorecki, Karl, Selig, Sara

“…Human induced pluripotent stem (hiPS) cells provide therapeutic promises, as well as a potent in vitro model for studying biological processes which take place…”
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The ARF1 GTPase-Activating Protein: Zinc Finger Motif and Golgi Complex Localization by Cukierman, Edna, Huber, Irit, Rotman, Miriam, Cassel, Dan

“…Hydrolysis of guanosine triphosphate (GTP) by the small guanosine triphosphatase (GTPase) adenosine diphosphate ribosylation factor-1. (ARF1) depends on a…”
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