Search Results - "Hubbell, J A"

Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering by Hubbell, J A, Lutolf, M P

“…New generations of synthetic biomaterials are being developed at a rapid pace for use as three-dimensional extracellular microenvironments to mimic the…”
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Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2 by Patterson, J, Hubbell, J.A

“…Abstract Bioactive hydrogels formed by Michael-type addition reactions of end-functionalized poly(ethylene glycol) macromers with cysteine-containing peptides…”
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Synthesis and Physicochemical Characterization of End-Linked Poly(ethylene glycol)-co-peptide Hydrogels Formed by Michael-Type Addition by Lutolf, M. P., Hubbell, J. A.

“…The synthesis of novel hybrid hydrogels by stepwise copolymerization of multiarm vinyl sulfone-terminated poly(ethylene glycol) macromers and α−ω cysteine…”
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Synthetic Matrix Metalloproteinase-Sensitive Hydrogels for the Conduction of Tissue Regeneration: Engineering Cell-Invasion Characteristics by Lutolf, M. P., Lauer-Fields, J. L., Schmoekel, H. G., Metters, A. T., Weber, F. E., Fields, G. B., Hubbell, J. A.

“…Synthetic hydrogels have been molecularly engineered to mimic the invasive characteristics of native provisional extracellular matrices: a combination of…”
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Systematic Modulation of Michael-Type Reactivity of Thiols through the Use of Charged Amino Acids by Lutolf, M. P, Tirelli, N, Cerritelli, S, Cavalli, L, Hubbell, J. A

“…A quantitative structure−reactivity relationship for the Michael-type addition of thiols onto acrylates was determined. Several thiol-containing peptides were…”
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SPARC-derived protease substrates to enhance the plasmin sensitivity of molecularly engineered PEG hydrogels by Patterson, J, Hubbell, J.A

“…Abstract Bioactive hydrogels formed from the Michael-type addition reactions of end-functionalized poly (ethylene glycol) macromers with thiol-containing…”
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Molecularly Engineered PEG Hydrogels: A Novel Model System for Proteolytically Mediated Cell Migration by Raeber, G.P., Lutolf, M.P., Hubbell, J.A.

“…Model systems mimicking the extracellular matrix (ECM) have greatly helped in quantifying cell migration in three dimensions and elucidated the molecular…”
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MMP-2 sensitive, VEGF-bearing bioactive hydrogels for promotion of vascular healing by Seliktar, D., Zisch, A. H., Lutolf, M. P., Wrana, J. L., Hubbell, J. A.

“…We sought to develop bioactive hydrogels to facilitate arterial healing, e.g., after balloon angioplasty. Toward this end, we developed a new class of…”
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IGF-1-containing multi-layered collagen-fibrin hybrid scaffolds for bladder tissue engineering by Vardar, E., Larsson, H.M., Engelhardt, E.M., Pinnagoda, K., Briquez, P.S., Hubbell, J.A., Frey, P.

“…[Display omitted] Clinical success of bladder reconstructive procedures could be promoted by the availability of functional biomaterials. In this study, we…”
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Microfluidic production of bioactive fibrin micro-beads embedded in crosslinked collagen used as an injectable bulking agent for urinary incontinence treatment by Vardar, E., Larsson, H.M., Allazetta, S., Engelhardt, E.M., Pinnagoda, K., Vythilingam, G., Hubbell, J.A., Lutolf, M.P., Frey, P.

“…[Display omitted] Endoscopic injection of bulking agents has been widely used to treat urinary incontinence, often due to urethral sphincter complex…”
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FUNCTIONAL BIOMATERIALS: Design of Novel Biomaterials by Sakiyama-Elbert, SE, Hubbell, JA

“…The field of biomaterials has recently been focused on the design of intelligent materials. Toward this goal, materials have been developed that can provide…”
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Pharmacokinetics of midazolam after intravenous administration to horses by Hubbell, J. A. E, Kelly, E. M, Aarnes, T. K, Bednarski, R. M, Lerche, P, Liu, Z, Lakritz, J

“…REASONS FOR PERFORMING THE STUDY: Midazolam is used to control seizures in horses and to enhance muscle relaxation, but its pharmacokinetics are unknown…”
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Mechanisms of 3-D migration and matrix remodeling of fibroblasts within artificial ECMs by Raeber, G.P., Lutolf, M.P., Hubbell, J.A.

“…The elucidation of molecular cell–extracellular matrix (ECM) interactions regulating tissue dynamics necessitates straightforward model systems that can…”
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Conjugate Addition Reactions Combined with Free-Radical Cross-Linking for the Design of Materials for Tissue Engineering by Elbert, Donald L, Hubbell, Jeffrey A

“…PEG−diacrylamide was synthesized and utilized to make materials for tissue engineering. Acrylamide groups readily react with thiol groups, and peptides…”
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Towards a fully synthetic substitute of alginate: Optimization of a thermal gelation/chemical cross-linking scheme ("tandem" gelation) for the production of beads and liquid-core capsules by Cellesi, F., Weber, W., Fussenegger, M., Hubbell, J.A., Tirelli, N.

“…Fully synthetic polymers were used for the preparation of hydrogel beads and capsules, in a processing scheme that, originally designed for calcium alginate,…”
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The selective modulation of endothelial cell mobility on RGD peptide containing surfaces by YIGSR peptides by Fittkau, M.H, Zilla, P, Bezuidenhout, D, Lutolf, M.P, Human, P, Hubbell, J.A, Davies, N

“…The ability of the biomimetic peptides YIGSR, PHSRN and RGD to selectively affect adhesion and migration of human microvascular endothelial cells (MVEC) and…”
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A New Living Emulsion Polymerization Mechanism:  Episulfide Anionic Polymerization by Rehor, A, Tirelli, N, Hubbell, J. A

“…The anionic ring-opening polymerization of episulfides has been successfully applied in emulsion. The polymerization proceeded with a living mechanism but was…”
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Chemisorbed poly(propylene sulphide)-based copolymers resist biomolecular interactions by Hubbell, J.A, Bearinger, J.P, Terrettaz, S, Michel, R, Tirelli, N, Vogel, H, Textor, M

“…Alkanethiolates have been widely used as chemisorbates to modify gold surfaces, in spite of their relatively poor oxidative stability. We introduce…”
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Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension by Hubbell, Jeffrey A, Schense, Jason C, Bloch, Jocelyne, Aebischer, Patrick

“…Fibrin plays an important role in wound healing and regeneration, and enjoys widespread use in surgery and tissue engineering. The enzymatic activity of Factor…”
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Electrochemical optical waveguide lightmode spectroscopy (EC-OWLS): A pilot study using evanescent-field optical sensing under voltage control to monitor polycationic polymer adsorption onto indium tin oxide (ITO)-coated waveguide chips by Bearinger, J. P., Vörös, J., Hubbell, J. A., Textor, M.

“…A new technique has been developed that combines evanescent‐field optical sensing with electrochemical control of surface adsorption processes. This new…”
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