Search Results - "Hubbard, Julia"

Phosphorylation of AMPK by upstream kinases is required for activity in mammalian cells by Willows, Robin, Sanders, Matthew J, Xiao, Bing, Patel, Bhakti R, Martin, Stephen R, Read, Jon, Wilson, Jon R, Hubbard, Julia, Gamblin, Steven J, Carling, David

“…AMP-activated protein kinase (AMPK) plays a major role in regulating metabolism and has attracted significant attention as a therapeutic target for treating…”
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P–T Evolution of the Cyclades Blueschist Unit: Constraints on the Evolution of a Nascent Subduction System From Zr‐In‐Rutile (ZiR) and Quartz‐In‐Garnet (QuiG) Thermobarometry by Spear, Frank S., Wolfe, Oliver M., Thomas, Jay B., Hubbard, Julia E., Castro, Adrian E., Cheney, John T.

“…New results that employ Zr‐in‐rutile thermometry (ZiR) and quartz‐inclusion‐in‐garnet (QuiG) barometry constrain the P–T conditions of garnet formation in…”
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The bacterial replication origin BUS promotes nucleobase capture by Pelliciari, Simone, Bodet-Lefèvre, Salomé, Fenyk, Stepan, Stevens, Daniel, Winterhalter, Charles, Schramm, Frederic D., Pintar, Sara, Burnham, Daniel R., Merces, George, Richardson, Tomas T., Tashiro, Yumiko, Hubbard, Julia, Yardimci, Hasan, Ilangovan, Aravindan, Murray, Heath

“…Genome duplication is essential for the proliferation of cellular life and this process is generally initiated by dedicated replication proteins at chromosome…”
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Production and Crystallization of Full-Length Human AMP-Activated Protein Kinase (α1β1γ1) by Hubbard, Julia A, Xiao, Bing, Wilson, Jon R

“…Determination of the crystal structure of AMP-activated protein kinase (AMPK) is fundamental to understanding its biological function and role in a number of…”
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Unlocking the secrets of the gatekeeper: Methods for stabilizing and crystallizing GPCRs by Bertheleme, Nicolas, Chae, Pil Seok, Singh, Shweta, Mossakowska, Danuta, Hann, Michael M., Smith, Kathrine J., Hubbard, Julia A., Dowell, Simon J., Byrne, Bernadette

“…G-protein coupled receptors (GPCRs) are integral membrane cell surface receptors with key roles in mediating the cellular responses to a wide range of…”
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Backbone resonance assignments of the catalytic and regulatory domains of Ca2+/calmodulin-dependent protein kinase 1D by Tong, Michael H. G., Jeeves, Mark, Rajesh, Sundaresan, Ludwig, Christian, Lenoir, Marc, Kumar, Jitendra, McClelland, Darren M., Berditchevski, Fedor, Hubbard, Julia A., Kenyon, Colin, Butterworth, Sam, Knapp, Stefan, Overduin, Michael

“…The CaMK subfamily of Ser/Thr kinases are regulated by calmodulin interactions with their C-terminal regions. They are exemplified by Ca 2+ /calmodulin…”
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Global Analysis of Proteins Synthesized by Mycobacterium smegmatis Provides Direct Evidence for Physiological Heterogeneity in Stationary-Phase Cultures by BLOKPOEL, Marian C. J, SMEULDERS, Marjan J, HUBBARD, Julia A. M, KEER, Jacquie, WILLIAMS, Huw D

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Synthesis and evaluation of novel α-amino cyclic boronates as inhibitors of HCV NS3 protease by Li, Xianfeng, Zhang, Yong-Kang, Liu, Yang, Ding, Charles Z., Li, Qun, Zhou, Yasheen, Plattner, Jacob J., Baker, Stephen J., Qian, Xuelei, Fan, Dazhong, Liao, Liang, Ni, Zhi-Jie, White, Gemma V., Mordaunt, Jackie E., Lazarides, Linos X., Slater, Martin J., Jarvest, Richard L., Thommes, Pia, Ellis, Malcolm, Edge, Colin M., Hubbard, Julia A., Somers, Don, Rowland, Paul, Nassau, Pamela, McDowell, Bill, Skarzynski, Tadeusz J., Kazmierski, Wieslaw M., Grimes, Richard M., Wright, Lois L., Smith, Gary K., Zou, Wuxin, Wright, Jon, Pennicott, Lewis E.

“…We have designed and synthesized a novel series of α-amino cyclic boronates and incorporated them successfully in several acyclic templates at the P1 position…”
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Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics by Charrier, Nicolas, Clarke, Brian, Cutler, Leanne, Demont, Emmanuel, Dingwall, Colin, Dunsdon, Rachel, Hawkins, Julie, Howes, Colin, Hubbard, Julia, Hussain, Ishrut, Maile, Graham, Matico, Rosalie, Mosley, Julie, Naylor, Alan, O’Brien, Alistair, Redshaw, Sally, Rowland, Paul, Soleil, Virginie, Smith, Kathrine J., Sweitzer, Sharon, Theobald, Pam, Vesey, David, Walter, Daryl S., Wayne, Gareth

“…This article discloses the strategy that led to stable hydroxyethylamine BACE-1 inhibitors with nanomolar cell potency and good oral bioavailability and give…”
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Novel macrocyclic HCV NS3 protease inhibitors derived from α-amino cyclic boronates by Li, Xianfeng, Zhang, Yong-Kang, Liu, Yang, Ding, Charles Z., Zhou, Yasheen, Li, Qun, Plattner, Jacob J., Baker, Stephen J., Zhang, Suoming, Kazmierski, Wieslaw M., Wright, Lois L., Smith, Gary K., Grimes, Richard M., Crosby, Renae M., Creech, Katrina L., Carballo, Luz H., Slater, Martin J., Jarvest, Richard L., Thommes, Pia, Hubbard, Julia A., Convery, Maire A., Nassau, Pamela M., McDowell, William, Skarzynski, Tadeusz J., Qian, Xuelei, Fan, Dazhong, Liao, Liang, Ni, Zhi-Jie, Pennicott, Lewis E., Zou, Wuxin, Wright, Jon

“…A novel series of P2–P4 macrocyclic HCV NS3/4A protease inhibitors with α-amino cyclic boronates as warheads at the P1 site was designed and synthesized. When…”
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Your travel checklist if you want a placement overseas by Hubbard, Julia, Beck, Katie

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Your travel checklist if you want a placement overseas: International clinical placements are rewarding but need careful planning to comply with NMC and visa rules by Hubbard, Julia, Beck, Katie

“…Embarking on an international clinical placement can be a transformative experience. These opportunities are not just about exploring new cultures and clinical…”
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Sulfonamide-related conformational effects and their importance in structure-based design by Senger, Stefan, Chan, Chuen, Convery, Máire A., Hubbard, Julia A., Shah, Gita P., Watson, Nigel S., Young, Robert J.

“…An example is presented where structural information combined with ab initio calculations clearly indicate that an observed difference in biological activity…”
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Nuclear magnetic resonance spectroscopy reveals the functional state of the signalling protein CheY in vivo in Escherichia coli by Hubbard, Julia A., MacLachlan, Lesley K., King, Gavin W., Jones, Joanna J., Fosberry, Andrew P.

“…Summary Two‐component signal transduction (TCST) pathways are regulatory systems that are highly homologous throughout the bacterial kingdom. Their established…”
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Selective and dual action orally active inhibitors of thrombin and factor Xa by Young, Robert J., Brown, David, Burns-Kurtis, Cynthia L., Chan, Chuen, Convery, Máire A., Hubbard, Julia A., Kelly, Henry A., Pateman, Anthony J., Patikis, Angela, Senger, Stefan, Shah, Gita P., Toomey, John R., Watson, Nigel S., Zhou, Ping

“…The synthetic entry to new classes of dual fXa/thrombin and selective thrombin inhibitors with significant oral bioavailability is described. The observed…”
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Predicting student nurse success: A behavioural science approach by Hubbard, Julia

“…This paper critically reviews and applies behavioural science theories and techniques to the practical problem of student nurse selection by universities. The…”
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NMR assignment of the conserved bacterial DNA replication protein DnaA domain IV by Abrams, Alexander Nguyen, Kelly, Geoff, Hubbard, Julia

“…Chromosomal replication is a ubiquitous and essential cellular process. In bacteria, the master replication initiator DnaA plays a key role in promoting an…”
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In Situ Quantification of Carbonate Species Concentrations, pH, and pCO 2 in Calcite Fluid Inclusions Using Confocal Raman Spectroscopy by Hudgins, Michael Naylor, Knobbe, Todd K., Hubbard, Julia, Steele, Andrew, Park, Justin G., Schaller, Morgan F.

“…Carbonate minerals are globally distributed on the modern and ancient Earth and are abundant in terrestrial and marine depositional environments. Fluid…”
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In Situ Quantification of Carbonate Species Concentrations, pH, and pCO2 in Calcite Fluid Inclusions Using Confocal Raman Spectroscopy by Hudgins, Michael Naylor, Knobbe, Todd K., Hubbard, Julia, Steele, Andrew, Park, Justin G., Schaller, Morgan F.

“…Carbonate minerals are globally distributed on the modern and ancient Earth and are abundant in terrestrial and marine depositional environments. Fluid…”
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In Situ Quantification of Carbonate Species Concentrations, pH, and pCO 2 in Calcite Fluid Inclusions Using Confocal Raman Spectroscopy by Hudgins, Michael Naylor, Knobbe, Todd K, Hubbard, Julia, Steele, Andrew, Park, Justin G, Schaller, Morgan F

“…Carbonate minerals are globally distributed on the modern and ancient Earth and are abundant in terrestrial and marine depositional environments. Fluid…”
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