Search Results - "Hubbard, Gretchen K."

Combined MYC Activation and Pten Loss Are Sufficient to Create Genomic Instability and Lethal Metastatic Prostate Cancer by Hubbard, Gretchen K, Mutton, Laura N, Khalili, May, McMullin, Ryan P, Hicks, Jessica L, Bianchi-Frias, Daniella, Horn, Lucas A, Kulac, Ibrahim, Moubarek, Michael S, Nelson, Peter S, Yegnasubramanian, Srinivasan, De Marzo, Angelo M, Bieberich, Charles J

“…Genetic instability, a hallmark feature of human cancers including prostatic adenocarcinomas, is considered a driver of metastasis. Somatic copy number…”
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MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer by Baena‐Del Valle, Javier A, Zheng, Qizhi, Esopi, David M, Rubenstein, Michael, Hubbard, Gretchen K, Moncaliano, Maria C, Hruszkewycz, Andrew, Vaghasia, Ajay, Yegnasubramanian, Srinivasan, Wheelan, Sarah J, Meeker, Alan K, Heaphy, Christopher M, Graham, Mindy K, De Marzo, Angelo M

“…Telomerase consists of at least two essential elements, an RNA component hTR or TERC that contains the template for telomere DNA addition and a catalytic…”
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MYC overexpression induces prostatic intraepithelial neoplasia and loss of Nkx3.1 in mouse luminal epithelial cells by Iwata, Tsuyoshi, Schultz, Denise, Hicks, Jessica, Hubbard, Gretchen K, Mutton, Laura N, Lotan, Tamara L, Bethel, Carlise, Lotz, Matthew T, Yegnasubramanian, Srinivasan, Nelson, William G, Dang, Chi V, Xu, MengMeng, Anele, Uzoma, Koh, Cheryl M, Bieberich, Charles J, De Marzo, Angelo M

“…Lo-MYC and Hi-MYC mice develop prostatic intraepithelial neoplasia (PIN) and prostatic adenocarcinoma as a result of MYC overexpression in the mouse prostate…”
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PD-L1 Expression Varies in Thyroid Cancer Types and Is Associated with Decreased Progression Free Survival (PFS) in Patients with Anaplastic Thyroid Cancer by Shobab, Leila, Al-Souri, Deema, Mathews-Kim, Liza, McCoy, Matthew, Kuenstner, William, Hubbard, Gretchen K, Kumari, Sonam, Chou, Jiling, Lee, Wen, Rosen, Jennifer, Klubo-Gwiezdzinska, Joanna, Atkins, Michael, Wartofsky, Leonard, Vasko, Vasyl, Burman, Kenneth

“…Background: Thyroid cancer (TC) remains a significant clinical challenge worldwide, with a subset of patients facing aggressive disease progression and…”
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Characterization of novel cell lines derived from a MYC‐driven murine model of lethal metastatic adenocarcinoma of the prostate by Markowski, Mark C., Hubbard, Gretchen K., Hicks, Jessica L., Zheng, Qizhi, King, Alexia, Esopi, David, Rege, Apurv, Yegnasubramanian, Srinivasan, Bieberich, Charles J., De Marzo, Angelo M.

“…Background: Loss or mutation of PTEN alleles at 10q23 in combination with 8q24 amplification (encompassing MYC) are common findings in aggressive, human…”
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Abstract 641: Use of conditional reprogramming to develop and characterize cell cultures from patient-derived xenograft (PDX) models of human lung and ovarian cancer by Borodovsky, Alexandra, McQuiston, Travis J., Dougherty, Brian, Ahmed, Ambar, Whitston, David, Stetson, Daniel, Hubbard, Gretchen K., Challberg, Sharon S., Pollok, Brian A., D’Cruz, Celina M.

“…Abstract Patient-derived xenografts (PDX) are widely recognized as a more physiologically relevant preclinical model to standard cell line xenografts. PDX…”
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Abstract 5021: Histopathologic and gene expression analysis in mouse models of long-term chronic prostatic inflammation using human prostate cancer-derived bacterial isolates by Hubbard, Gretchen K., Yu, Shu-Han, Shinohara, Debika Biswal, Vaghasia, Ajay, Nelson, William G., Yegnasubramanian, Srinivasan, De Marzo, Angelo M., Sfanos, Karen S.

“…Abstract Prostate cancer is the second leading cause of cancer death in the U.S. and afflicts 1 in 6 men in their lifetime. Evidence suggests that inflammation…”
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Abstract 1086: MYC overexpression combined with Pten loss generates genomic instability and rapid metastasis in a new mouse model of lethal prostate adenocarcinoma by Hubbard, Gretchen K., Mutton, Laura N., Khalili, May, McMullin, Ryan P., Hicks, Jessica, Bianchi-Frias, Daniella, Nelson, Peter S., Yegnasubramanian, Srinivasan, De Marzo, Angelo M., Bieberich, Charles J.

“…Abstract There is a pressing need for animal models that recapitulate key pathological features of lethal human prostate adenocarcinoma. The availability of…”
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