Search Results - "Hubbard, E R"

Frailty and post-operative outcomes in older surgical patients: a systematic review by Lin, Hui-Shan, Watts, J N, Peel, N M, Hubbard, R E

“…As the population ages, increasing numbers of older adults are undergoing surgery. Frailty is prevalent in older adults and may be a better predictor of…”
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Frailty in older inpatients: what physicians need to know by MCMILLAN, G. J, HUBBARD, R. E

“…Physicians involved in the care of medical inpatients, irrespective of their sub-specialty area, will be responsible for the management of a significant number…”
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Validation of a frailty index in older cancer patients with solid tumours by McCarthy, A L, Peel, N M, Gillespie, K M, Berry, R, Walpole, E, Yates, P, Hubbard, R E

“…Frailty is an indicator of physiological reserve in older people. In non-cancer settings, frailty indices are reliable predictors of adverse health outcomes…”
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How frail is frail? A systematic scoping review and synthesis of high impact studies by Gordon, E H, Reid, N, Khetani, I S, Hubbard, R E

“…While the frailty index (FI) is a continuous variable, an FI score of 0.25 has construct and predictive validity to categorise community-dwelling older adults…”
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Comparison of the prognostic importance of diagnosed diabetes, co-morbidity and frailty in older people by Hubbard, R. E., Andrew, M. K., Fallah, N., Rockwood, K.

“…Diabet. Med. 27, 603–606 (2010) Aims  To compare the relative prognostic importance in older people of diagnosed diabetes, the number and severity of…”
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Income and the midlife peak in common mental disorder prevalence by Lang, I A, Llewellyn, D J, Hubbard, R E, Langa, K M, Melzer, D

“…The prevalence of psychological distress and common mental disorders has been shown to peak in midlife but analyses have ignored the association of poor…”
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Drug-like Annotation and Duplicate Analysis of a 23-Supplier Chemical Database Totalling 2.7 Million Compounds by Baurin, N, Baker, R, Richardson, C, Chen, I, Foloppe, N, Potter, A, Jordan, A, Roughley, S, Parratt, M, Greaney, P, Morley, D, Hubbard, R. E

“…We have implemented five drug-like filters, based on 1D and 2D molecular descriptors, and applied them to characterize the drug-like properties of commercially…”
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Effect of smoking on the accumulation of deficits, frailty and survival in older adults: A secondary analysis from the Canadian study of health and aging by Hubbard, R. E., Searle, S. D., Mitnitski, A., Rockwood, K.

“…Objectives Smoking has adverse effects on a variety of organ systems but little is known about the relationship between smoking and frailty. We aimed to…”
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Perioperative assessment of older surgical patients using a frailty index - feasibility and association with adverse postoperative outcomes by Lin, H., Peel, N. M., Scott, I. A., Vardesh, D. L., Sivalingam, P., McBride, R. L., Morong, J. J., Nelson, M. J., Hubbard, R. E.

“…This study aimed to examine the feasibility of using a frailty index (FI) based on comprehensive geriatric assessment (CGA), to assess the level of frailty in…”
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Do sex differences in chronic disease underpin the sex-frailty paradox? by Gordon, E.H., Hubbard, R.E.

“…•The ‘male-female health-survival paradox’ is a well-described clinical phenomenon.•This paradox may also be conceptualized as a ‘sex-frailty…”
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The Utility of the Frailty Index in Clinical Decision Making by Khatry, K, Peel, N M, Gray, L C, Hubbard, R E

“…Using clinical vignettes, this study aimed to determine if a measure of patient frailty would impact management decisions made by geriatricians regarding…”
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Sex differences in frailty: A systematic review and meta-analysis by Gordon, E.H., Peel, N.M., Samanta, M., Theou, O., Howlett, S.E., Hubbard, R.E.

“…It is a well-described clinical phenomenon that females live longer than males, yet tend to experience greater levels of co-morbidity and disability. Females…”
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Patient frailty: the elephant in the operating room by Hubbard, R. E., Story, D. A.

“…Summary For most surgeons and many anaesthetists, patient frailty is currently the ‘elephant in the (operating) room’: it is easy to spot, but is often…”
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Molecular basis of agonism and antagonism in the oestrogen receptor by Brzozowski, Andrzej M, Pike, Ashley C. W, Dauter, Zbigniew, Hubbard, Roderick E, Bonn, Tomas, Engström, Owe, Öhman, Lars, Greene, Geoffrey L, Gustafsson, Jan-Åke, Carlquist, Mats

“…Oestrogens are involved in the growth, development and homeostasis of a number of tissues. The physiological effects of these steroids are mediated by a…”
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Frailty in younger adults in hospital by Gordon, E H, Peel, N M, Hubbard, R E, Reid, N

“…Summary Background Even though frailty has been extensively measured in the acute care setting, relatively little is known about the frailty of younger adult…”
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Frailty, Body Mass Index, and Abdominal Obesity in Older People by Hubbard, Ruth E., Lang, Iain A., Llewellyn, David J., Rockwood, Kenneth

“…Background Frailty has been conceptualized as a wasting disorder with weight loss as a key component. However, obesity is associated with disability and with…”
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The impact of frailty and delirium on mortality in older inpatients by Eeles, Eamonn M P, White, Susan V, O'Mahony, Sinead M, Bayer, Antony J, Hubbard, Ruth E

“…delirium and frailty are common among hospitalised older people but delirium is often missed and frailty considered difficult to measure in clinical practice…”
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COMPARISON OF TWO FRAILTY MEASURES IN THE CONSELICE STUDY OF BRAIN AGEING by LUCICESARE, A, HUBBARD, R. E, FALLAH, N, FORTI, P, SEARLE, S. D, MITNITSKI, A, RAVAGLIA, G, ROCKWOOD, K

“…Uncertainty about the definition of frailty is reflected by the development of many ways to identify frail people. We aimed to compare the validity of two…”
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Frailty: A cost incurred by reproduction? by Gordon, E. H., Peel, N. M., Chatfield, M. D., Lang, I. A., Hubbard, R. E.

“…Evolutionary theories of senescence, such as the ‘disposable soma’ theory, propose that natural selection trades late survival for early fecundity. ‘Frailty’,…”
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Virtual screening in structure-based drug discovery by Barril, X, Hubbard, R E, Morley, S D

“…Recent advances in structure determination and computational methods have encouraged the development of structure-based virtual screening. Here we survey…”
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