Search Results - "Hubank, Mike"

A global profile of replicative polymerase usage by Daigaku, Yasukazu, Keszthelyi, Andrea, Müller, Carolin A, Miyabe, Izumi, Brooks, Tony, Retkute, Renata, Hubank, Mike, Nieduszynski, Conrad A, Carr, Antony M

“…Genome-wide DNA polymerase usage maps determined in fission yeast, using a new sequencing strategy based on ribonucleotide misincorporation, track the division…”
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Astrovirus VA1/HMO-C: An Increasingly Recognized Neurotropic Pathogen in Immunocompromised Patients by Brown, Julianne R., Morfopoulou, Sofia, Hubb, Jonathan, Emmett, Warren A., Ip, Winnie, Shah, Divya, Brooks, Tony, Paine, Simon M. L., Anderson, Glenn, Virasami, Alex, Tong, C. Y. William, Clark, Duncan A., Plagnol, Vincent, Jacques, Thomas S., Qasim, Waseem, Hubank, Mike, Breuer, Judith

“…Background. An 18-month-old boy developed encephalopathy, for which extensive investigation failed to identify an etiology, 6 weeks after stem cell transplant…”
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Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina by Gonzalez-Cordero, Anai, West, Emma L, Pearson, Rachael A, Duran, Yanai, Carvalho, Livia S, Chu, Colin J, Naeem, Arifa, Blackford, Samuel J I, Georgiadis, Anastasios, Lakowski, Jorn, Hubank, Mike, Smith, Alexander J, Bainbridge, James W B, Sowden, Jane C, Ali, Robin R

“…Optic cup-like structures generated from mouse ES cells produce photoreceptor precursors that integrate and mature in vivo in three models of retinal…”
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Genetic complexity in hypertrophic cardiomyopathy revealed by high-throughput sequencing by Lopes, Luis R, Zekavati, Anna, Syrris, Petros, Hubank, Mike, Giambartolomei, Claudia, Dalageorgou, Chrysoula, Jenkins, Sharon, McKenna, William, Plagnol, Vincent, Elliott, Perry M

“…Clinical interpretation of the large number of rare variants identified by high throughput sequencing (HTS) technologies is challenging. The aim of this study…”
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Inactivating NF1 Mutations Are Enriched in Advanced Breast Cancer and Contribute to Endocrine Therapy Resistance by Pearson, Alex, Proszek, Paula, Pascual, Javier, Fribbens, Charlotte, Shamsher, Monee K, Kingston, Belinda, O'Leary, Ben, Herrera-Abreu, Maria T, Cutts, Rosalind J, Garcia-Murillas, Isaac, Bye, Hannah, Walker, Brian A, Gonzalez De Castro, David, Yuan, Lina, Jamal, Sabri, Hubank, Mike, Lopez-Knowles, Elena, Schuster, Eugene F, Dowsett, Mitch, Osin, Peter, Nerurkar, Ashutosh, Parton, Marina, Okines, Alicia F C, Johnston, Stephen R D, Ring, Alistair, Turner, Nicholas C

“…Advanced breast cancer (ABC) has not been subjected to the same degree of molecular scrutiny as early primary cancer. Breast cancer evolves with time and under…”
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Same Exposure but Two Radically Different Responses to Antibiotics: Resilience of the Salivary Microbiome versus Long-Term Microbial Shifts in Feces by Zaura, Egija, Brandt, Bernd W, Teixeira de Mattos, M Joost, Buijs, Mark J, Caspers, Martien P M, Rashid, Mamun-Ur, Weintraub, Andrej, Nord, Carl Erik, Savell, Ann, Hu, Yanmin, Coates, Antony R, Hubank, Mike, Spratt, David A, Wilson, Michael, Keijser, Bart J F, Crielaard, Wim

“…Due to the spread of resistance, antibiotic exposure receives increasing attention. Ecological consequences for the different niches of individual microbiomes…”
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High throughput sequencing in acute lymphoblastic leukemia reveals clonal architecture of central nervous system and bone marrow compartments by Bartram, Jack, Goulden, Nick, Wright, Gary, Adams, Stuart, Brooks, Tony, Edwards, Darren, Inglott, Sarah, Yousafzai, Yasar, Hubank, Mike, Halsey, Christina

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Mutations in ALK signaling pathways conferring resistance to ALK inhibitor treatment lead to collateral vulnerabilities in neuroblastoma cells by Berlak, Mareike, Tucker, Elizabeth, Dorel, Mathurin, Winkler, Annika, McGearey, Aleixandria, Rodriguez-Fos, Elias, da Costa, Barbara Martins, Barker, Karen, Fyle, Elicia, Calton, Elizabeth, Eising, Selma, Ober, Kim, Hughes, Deborah, Koutroumanidou, Eleni, Carter, Paul, Stankunaite, Reda, Proszek, Paula, Jain, Neha, Rosswog, Carolina, Dorado-Garcia, Heathcliff, Molenaar, Jan Jasper, Hubank, Mike, Barone, Giuseppe, Anderson, John, Lang, Peter, Deubzer, Hedwig Elisabeth, Künkele, Annette, Fischer, Matthias, Eggert, Angelika, Kloft, Charlotte, Henssen, Anton George, Boettcher, Michael, Hertwig, Falk, Blüthgen, Nils, Chesler, Louis, Schulte, Johannes Hubertus

“…Development of resistance to targeted therapies has tempered initial optimism that precision oncology would improve poor outcomes for cancer patients…”
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Isolation and Comparative Transcriptome Analysis of Human Fetal and iPSC-Derived Cone Photoreceptor Cells by Welby, Emily, Lakowski, Jorn, Di Foggia, Valentina, Budinger, Dimitri, Gonzalez-Cordero, Anai, Lun, Aaron T.L., Epstein, Michael, Patel, Aara, Cuevas, Elisa, Kruczek, Kamil, Naeem, Arifa, Minneci, Federico, Hubank, Mike, Jones, David T., Marioni, John C., Ali, Robin R., Sowden, Jane C.

“…Loss of cone photoreceptors, crucial for daylight vision, has the greatest impact on sight in retinal degeneration. Transplantation of stem cell-derived…”
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High‐throughput sequencing of peripheral blood for minimal residual disease monitoring in childhood precursor B‐cell acute lymphoblastic leukemia: A prospective feasibility study by Bartram, Jack, Wright, Gary, Adams, Stuart, Archer, Paul, Brooks, Tony, Edwards, Darren, Hancock, Jerry, Knecht, Henrik, Inglott, Sarah, Mountjoy, Edward, Roynane, Marie, Wakeman, Stephanie, Moppett, John, Hubank, Mike, Goulden, Nick

“…Background Minimal residual disease (MRD) measured on end‐of‐induction bone marrow (BM) is the most important biomarker for guiding therapy in pediatric acute…”
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The kinetochore protein, CENPF, is mutated in human ciliopathy and microcephaly phenotypes by Waters, Aoife M, Asfahani, Rowan, Carroll, Paula, Bicknell, Louise, Lescai, Francesco, Bright, Alison, Chanudet, Estelle, Brooks, Anthony, Christou-Savina, Sonja, Osman, Guled, Walsh, Patrick, Bacchelli, Chiara, Chapgier, Ariane, Vernay, Bertrand, Bader, David M, Deshpande, Charu, O' Sullivan, Mary, Ocaka, Louise, Stanescu, Horia, Stewart, Helen S, Hildebrandt, Friedhelm, Otto, Edgar, Johnson, Colin A, Szymanska, Katarzyna, Katsanis, Nicholas, Davis, Erica, Kleta, Robert, Hubank, Mike, Doxsey, Stephen, Jackson, Andrew, Stupka, Elia, Winey, Mark, Beales, Philip L

“…Mutations in microtubule-regulating genes are associated with disorders of neuronal migration and microcephaly. Regulation of centriole length has been shown…”
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Transcriptional instability during evolving sepsis may limit biomarker based risk stratification by Kwan, Antonia, Hubank, Mike, Rashid, Asrar, Klein, Nigel, Peters, Mark J

“…Sepsis causes extensive morbidity and mortality in children worldwide. Prompt recognition and timely treatment of sepsis is critical in reducing morbidity and…”
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Global analysis of gene expression in NGF-deprived sympathetic neurons identifies molecular pathways associated with cell death by Kristiansen, Mark, Menghi, Francesca, Hughes, Rosie, Hubank, Mike, Ham, Jonathan

“…Developing sympathetic neurons depend on nerve growth factor (NGF) for survival and die by apoptosis after NGF withdrawal. This process requires de novo gene…”
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A genomic atlas of human adrenal and gonad development by Del Valle, Ignacio, Buonocore, Federica, Duncan, Andrew J, Lin, Lin, Barenco, Martino, Parnaik, Rahul, Shah, Sonia, Hubank, Mike, Gerrelli, Dianne, Achermann, John C

“…In humans, the adrenal glands and gonads undergo distinct biological events between 6-10 weeks post conception (wpc), such as testis determination, the onset…”
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Prox1 maintains muscle structure and growth in the developing heart by Risebro, Catherine A, Searles, Richelle G, Melville, Athalie A D, Ehler, Elisabeth, Jina, Nipurna, Shah, Sonia, Pallas, Jacky, Hubank, Mike, Dillard, Miriam, Harvey, Natasha L, Schwartz, Robert J, Chien, Kenneth R, Oliver, Guillermo, Riley, Paul R

“…Impaired cardiac muscle growth and aberrant myocyte arrangement underlie congenital heart disease and cardiomyopathy. We show that cardiac-specific…”
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A pathogenic mosaic TP53 mutation in two germ layers detected by next generation sequencing by Behjati, Sam, Maschietto, Mariana, Williams, Richard D, Side, Lucy, Hubank, Mike, West, Rebecca, Pearson, Katie, Sebire, Neil, Tarpey, Patrick, Futreal, Andrew, Brooks, Tony, Stratton, Michael R, Anderson, John

“…Li-Fraumeni syndrome is caused by germline TP53 mutations and is clinically characterized by a predisposition to a range of cancers, most commonly sarcoma,…”
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Risk HLA-DQA1 and PLA2R1 Alleles in Idiopathic Membranous Nephropathy by STANESCU, Horia C, ARCOS-BURGOS, Mauricio, STEPHENS, Henry A. F, LAUNDY, Valerie, PADMANABHAN, Sandosh, ZAWADZKA, Anna, HOFSTRA, Julia M, COENEN, Marieke J. H, DEN HEIJER, Martin, KIEMENEY, Lambertus A. L. M, BACQ-DAIAN, Delphine, STENGEL, Benedicte, MEDLAR, Alan, POWIS, Stephen H, BRENCHLEY, Paul, FEEHALLY, John, REES, AndrewJ, DEBIEC, Hanna, WETZELS, Jack F. M, RONCO, Pierre, MATHIESON, Peter W, KLETA, Robert, BOCKENHAUER, Detlef, KOTTGEN, Anna, DRAGOMIRESCU, Liviu, VOINESCU, Catalin, PATEL, Naina, PEARCE, Kerra, HUBANK, Mike

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Sterol O-Acyltransferase 1 (SOAT1, ACAT) Is a Novel Target of Steroidogenic Factor-1 (SF-1, NR5A1, Ad4BP) in the Human Adrenal by Ferraz-de-Souza, Bruno, Hudson-Davies, Rebecca E, Lin, Lin, Parnaik, Rahul, Hubank, Mike, Dattani, Mehul T, Achermann, John C

“…We used up- and down-regulation of the nuclear receptor steroidogenic factor-1 (SF-1, NR5A1, Ad4BP) to identify new components of adrenal function and…”
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Subtype-Specific FBXW7 Mutation and MYCN Copy Number Gain in Wilms' Tumor by WILLIAMS, Richard D, AL-SAADI, Reem, HUBANK, Mike, JONES, Chris, VUJANIC, Gordan, PRITCHARD-JONES, Kathy, CANCER, Children's, GROUP, Leukaemia, CHAGTAI, Tasnim, POPOV, Sergey, MESSAHEL, Boo, SEBIRE, Neil, GESSIER, Manfred, WEGERT, Jenny, GRAF, Norbert, LEUSCHNER, Ivo

“…Wilms' tumor (WT), the most common pediatric renal malignancy, is associated with mutations in several well-characterized genes, most notably WT1, CTNNB1, WTX,…”
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Cord blood transplantation recapitulates fetal ontogeny with a distinct molecular signature that supports CD4+ T-cell reconstitution by Hiwarkar, Prashant, Hubank, Mike, Qasim, Waseem, Chiesa, Robert, Gilmour, Kimberly C., Saudemont, Aurore, Amrolia, Persis J., Veys, Paul

“…Omission of in vivo T-cell depletion promotes rapid, thymic-independent CD4+-biased T-cell recovery after cord blood transplant. This enhanced T-cell…”
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