Search Results - "Hubal, Monica"

Lengthening our perspective: Morphological, cellular, and molecular responses to eccentric exercise by Hyldahl, Robert D., Hubal, Monica J.

“…ABSTRACT The response of skeletal muscle to unaccustomed eccentric exercise has been studied widely, yet it is incompletely understood. This review is intended…”
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Adipocyte exosomes induce transforming growth factor beta pathway dysregulation in hepatocytes: a novel paradigm for obesity-related liver disease by Koeck, Emily S., MD, Iordanskaia, Tatiana, PhD, Sevilla, Samantha, MFS, Ferrante, Sarah C., BS, Hubal, Monica J., PhD, Freishtat, Robert J., MD, Nadler, Evan P., MD

“…Abstract Background The pathogenesis of nonalcoholic fatty liver disease (NAFLD) has been attributed to increased systemic inflammation and insulin resistance…”
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Extracellular matrix remodeling and its contribution to protective adaptation following lengthening contractions in human muscle by Hyldahl, Robert D., Nelson, Brad, Xin, Ling, Welling, Tyson, Groscost, Logan, Hubal, Monica J., Chipkin, Stuart, Clarkson, Priscilla M., Parcell, Allen C.

“…ABSTRACT This study determined the contribution of extracellular matrix (ECM) remodeling to the protective adaptation of human skeletal muscle known as the…”
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Adipocyte-derived exosomal miRNAs: a novel mechanism for obesity-related disease by Ferrante, Sarah C., Nadler, Evan P., Pillai, Dinesh K., Hubal, Monica J., Wang, Zuyi, Wang, Justin M., Gordish-Dressman, Heather, Koeck, Emily, Sevilla, Samantha, Wiles, Andrew A., Freishtat, Robert J.

“…Background: Obesity is frequently complicated by comorbid conditions, yet how excess adipose contributes is poorly understood. Although adipocytes in obese…”
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Common Markers of Muscle Damage are Associated with Divergent Gene Expression Patterns after Eccentric Contractions by Deyhle, Michael R, Tiede, Dakota, Xin, Ling, Hyldahl, Robert D, Hubal, Monica J

“…Unaccustomed eccentric (ECC) exercise evokes exercise-induced muscle damage (EIMD). Soreness, strength loss and serum creatine kinase (CK) are often used to…”
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Systems Exercise Genetics Research Design Standards by Lightfoot, J. Timothy, Roth, Stephen M., Hubal, Monica J.

“…It is clear, based on a deep scientific literature base, that genetic and genomic factors play significant roles in determining a wide range of sport and…”
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Altered skeletal muscle metabolic pathways, age, systemic inflammation, and low cardiorespiratory fitness associate with improvements in disease activity following high-intensity interval training in persons with rheumatoid arthritis by Andonian, Brian J, Johannemann, Andrew, Hubal, Monica J, Pober, David M, Koss, Alec, Kraus, William E, Bartlett, David B, Huffman, Kim M

“…Exercise training, including high-intensity interval training (HIIT), improves rheumatoid arthritis (RA) inflammatory disease activity via unclear mechanisms…”
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Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness by Huffman, Kim M., Koves, Timothy R., Hubal, Monica J., Abouassi, Hiba, Beri, Nina, Bateman, Lori A., Stevens, Robert D., Ilkayeva, Olga R., Hoffman, Eric P., Muoio, Deborah M., Kraus, William E.

“…Aims/hypothesis Targeted metabolomic and transcriptomic approaches were used to evaluate the relationship between skeletal muscle metabolite signatures, gene…”
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Molecular alterations in skeletal muscle in rheumatoid arthritis are related to disease activity, physical inactivity, and disability by Huffman, Kim M, Jessee, Ryan, Andonian, Brian, Davis, Brittany N, Narowski, Rachel, Huebner, Janet L, Kraus, Virginia B, McCracken, Julie, Gilmore, Brian F, Tune, K Noelle, Campbell, Milton, Koves, Timothy R, Muoio, Deborah M, Hubal, Monica J, Kraus, William E

“…To identify molecular alterations in skeletal muscle in rheumatoid arthritis (RA) that may contribute to ongoing disability in RA. Persons with seropositive or…”
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Angiogenic potential of skeletal muscle derived extracellular vesicles differs between oxidative and glycolytic muscle tissue in mice by Kargl, Christopher K., Jia, Zhihao, Shera, Deborah A., Sullivan, Brian P., Burton, Lundon C., Kim, Kun Ho, Nie, Yaohui, Hubal, Monica J., Shannahan, Jonathan H., Kuang, Shihuan, Gavin, Timothy P.

“…Skeletal muscle fibers regulate surrounding endothelial cells (EC) via secretion of numerous angiogenic factors, including extracellular vesicles (SkM-EV)…”
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Exercise-induced muscle damage in humans by Clarkson, Priscilla M, Hubal, Monica J

“…Exercise-induced muscle injury in humans frequently occurs after unaccustomed exercise, particularly if the exercise involves a large amount of eccentric…”
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Rheumatoid arthritis T cell and muscle oxidative metabolism associate with exercise-induced changes in cardiorespiratory fitness by Andonian, Brian J., Koss, Alec, Koves, Timothy R., Hauser, Elizabeth R., Hubal, Monica J., Pober, David M., Lord, Janet M., MacIver, Nancie J., St Clair, E. William, Muoio, Deborah M., Kraus, William E., Bartlett, David B., Huffman, Kim M.

“…Rheumatoid arthritis (RA) T cells drive autoimmune features via metabolic reprogramming that reduces oxidative metabolism. Exercise training improves…”
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Exercise and weight loss interventions and miRNA expression in women with breast cancer by Adams, Brian D., Arem, Hannah, Hubal, Monica J., Cartmel, Brenda, Li, Fangyong, Harrigan, Maura, Sanft, Tara, Cheng, Christopher J., Pusztai, Lajos, Irwin, Melinda L.

“…Purpose Obesity and weight gain are associated with comorbidities including a higher risk of tumor recurrence and cancer-related deaths among breast cancer…”
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The effects of an acute exercise bout on GH and IGF-1 in prediabetic and healthy African Americans: A pilot study investigating gene expression by Berry, Nathaniel T, Hubal, Monica, Wideman, Laurie

“…The incidence of pre-diabetes (PD) and Type-2 Diabetes Mellitus (T2D) is a worldwide epidemic. African American (AA) individuals are disproportionately more…”
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Extracellular microRNA signature in chronic kidney disease by Muralidharan, Jagdeesan, Ramezani, Ali, Hubal, Monica, Knoblach, Susan, Shrivastav, Shashi, Karandish, Sara, Scott, Richard, Maxwell, Nirmal, Ozturk, Savas, Beddhu, Srinivasan, Kopp, Jeffrey B, Raj, Dominic S

“…MicroRNAs (miRNAs) are noncoding RNAs that regulate posttranscriptional gene expression. In this study we characterized the circulating and urinary miRNA…”
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Genome-Wide Genetic Analysis of Dropout in a Controlled Exercise Intervention in Sedentary Adults With Overweight or Obesity and Cardiometabolic Disease by Jiang, Rong, Collins, Katherine A, Huffman, Kim M, Hauser, Elizabeth R, Hubal, Monica J, Johnson, Johanna L, Williams, Redford B, Siegler, Ilene C, Kraus, William E

“…Abstract Background Despite the benefits of exercise, many individuals are unable or unwilling to adopt an exercise intervention. Purpose The purpose of this…”
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Obesity and exercise training alter inflammatory pathway skeletal muscle small extracellular vesicle microRNAs by Sullivan, Brian P., Nie, Yaohui, Evans, Sheelagh, Kargl, Chris K., Hettinger, Zach R., Garner, Ron T., Hubal, Monica J., Kuang, Shihuan, Stout, Julianne, Gavin, Timothy P.

“…New Findings What is the central question of this study? Is 1 week of exercise training sufficient to reduce local and systemic inflammation? Do obesity and…”
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Acute Resistance Exercise Modifies Extracellular Vesicle miRNAs Targeting Anabolic Gene Pathways: A Prospective Cohort Study by Conkright, William R, Kargl, Chris K, Hubal, Monica J, Tiede, Dakota R, Beckner, Meaghan E, Sterczala, Adam J, Krajewski, Kellen T, Martin, Brian J, Flanagan, Shawn D, Greeves, Julie P, O'Leary, Thomas J, Wardle, Sophie L, Sahu, Amrita, Ambrosio, Fabrisia, Nindl, Bradley C

“…Resistance training confers numerous health benefits that are mediated in part by circulating factors. Toward an enhanced molecular understanding, there is…”
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Consumption of Diet Soda Sweetened with Sucralose and Acesulfame‐Potassium Alters Inflammatory Transcriptome Pathways in Females with Overweight and Obesity by Sylvetsky, Allison C., Sen, Sabyasachi, Merkel, Patrick, Dore, Fiona, Stern, David B., Henry, Curtis J., Cai, Hongyi, Walter, Peter J., Crandall, Keith A., Rother, Kristina I., Hubal, Monica J.

“…Scope Low‐calorie sweetener (LCS) consumption is associated with metabolic disease in observational studies. However, physiologic mechanisms underlying…”
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Type 2 Diabetes Modifies Skeletal Muscle Gene Expression Response to Gastric Bypass Surgery by Barberio, Matthew D, Dohm, G Lynis, Pories, Walter J, Gadaleta, Natalie A, Houmard, Joseph A, Nadler, Evan P, Hubal, Monica J

“…Roux-en-Y gastric bypass (RYGB) is an effective treatment for type 2 diabetes mellitus (T2DM) that can result in remission of clinical symptoms, yet mechanisms…”
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