Search Results - "Hubáček, J A"

Genetics of T2DM and Its Chronic Complications: Are We Any Closer to the Individual Prediction of Genetic Risk? by Galuška, D, Dlouhá, L, Hubáček, J A, Kaňová, K

“…Type 2 diabetes mellitus (T2DM) is a complex disease that has risen in global prevalence over recent decades, resulting in concomitant and enormous…”
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Regulatory RNAs and cardiovascular disease - with a special focus on circulating microRNAs by Dlouhá, D, Hubáček, J A

“…MicroRNAs (miRNAs) are a class of short non-coding regulatory RNA molecules which play an important role in intracellular communication and cell signaling and…”
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Polymorphisms in IFN-γ, TNF-α and IL-10 in patients on maintenance haemodialysis by Bloudíčková, S, Kuthanová, L, Hubáček, J A

“…The dysbalance in the expression of proinflammatory and anti-inflammatory cytokines, which is partially genetically determined, might have essential impact on…”
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Comparison of the relative telomere length measured in leukocytes and eleven different human tissues by Dlouha, D, Maluskova, J, Kralova Lesna, I, Lanska, V, Hubacek, J A

“…The relative length of telomeres measured in peripheral blood leukocytes is a commonly used system marker for biological aging and can also be used as a…”
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Eat less and exercise more - is it really enough to knock down the obesity pandemia? by Hubáček, J A

“…Reduced physical activity and abundant energy intake are two most common factors leading to uncontrolled body weight gain. But these factors are not under…”
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FTO variant, energy intake, physical activity and basal metabolic rate in Caucasians. The HAPIEE study by Hubáček, J A, Pikhart, H, Peasey, A, Kubínová, R, Bobák, M

“…The FTO gene variants are the most important genetic determinants of body weight and obesity known so far, but the mechanism of their effect remains unclear…”
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Nobody Is Perfect: Comparison of the Accuracy of PCR-RFLP and KASP™ Method for Genotyping. ADH1B and FTO Polymorphisms as Examples by Hubáček, J A, Pikhart, H, Peasey, A, Kubínová, R, Bobák, M

“…DNA genotyping is among the most common analyses currently performed in scientific research. Two high-throughput genotyping techniques are widely used - the…”
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Association between fasting plasma triglycerides, all-cause and cardiovascular mortality in Czech population. Results from the HAPIEE study by Pikhart, H, Hubáček, J A, Peasey, A, Kubínová, R, Bobák, M

“…Dyslipidemia is the risk factor of cardiovascular disease, but the relationship between the plasma triglyceride (TG) levels and total/cardiovascular mortality…”
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Aldehyde dehydrogenase 2 polymorphism affects the outcome of methanol poisoning in exposed humans by Hubacek, J.A., Jirsa, M., Bobak, M., Pelclova, D., Zakharov, S.

“…As the susceptibility of humans to xenobiotics often depends on genetic factors, we assumed that ADH1B and ALDH2 genetic variants may affect susceptibility to…”
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Genetic Markers at ANRIL, FTO and 2q36.3 Locus in Czech Patients Undergoing Coronary Artery Bypass Graft Surgery by Kacer, P, Pirk, J, Lanska, V, Hubacek, J A, Adamek, V, Cervinkova, T, Belohoubek, J, Auzky, O, Adamkova, V

“…Coronary artery bypass graft (CABG) surgery is one of the most commonly performed operations worldwide. We compared genotype frequencies of three major…”
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Statin-associated myopathy: from genetic predisposition to clinical management by Vrablik, M, Zlatohlavek, L, Stulc, T, Adamkova, V, Prusikova, M, Schwarzova, L, Hubacek, J A, Ceska, R

“…Statin-associated myopathy (SAM) represents a broad spectrum of disorders from insignificant myalgia to fatal rhabdomyolysis. Its frequency ranges from 1-5 %…”
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Genetic predisposition of human plasma triglyceride concentrations by Schwarzova, L, Hubacek, J A, Vrablik, M

“…The issue of plasma triglyceride levels relative to the risk of development of cardiovascular disease, as well as overall mortality, has been actively…”
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Body mass index change in females after short-time life style intervention is not dependent on the FTO polymorphisms by Dlouhá, D, Suchánek, P, Lánská, V, Hubáček, J A

“…Variants within the FTO gene are important determinants of body mass index (BMI), but their role in determination of BMI changes after combined…”
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Impact of variants within seven candidate genes on statin treatment efficacy by Vrablík, M, Hubáček, J A, Dlouhá, D, Lánská, V, Rynekrová, J, Zlatohlávek, L, Prusíková, M, Ceška, R, Adámková, V

“…Statins are the most commonly used drugs in patients with dyslipidemia. Among the patients, a significant inter-individual variability with supposed strong…”
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An Apolipoprotein Influencing Triglycerides in Humans and Mice Revealed by Comparative Sequencing by Pennacchio, Len A., Olivier, Michael, Hubacek, Jaroslav A., Cohen, Jonathan C., Cox, David R., Fruchart, Jean-Charles, Krauss, Ronald M., Rubin, Edward M.

“…Comparison of genomic DNA sequences from human and mouse revealed a new apolipoprotein (APO) gene (APOAV) located proximal to the well-characterized…”
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The A-204C polymorphism in the cholesterol 7α-hydroxylase (CYP7A1) gene determines the cholesterolemia responsiveness to a high-fat diet by Kovář, J, Hubáček, JA, Suchánek, P, Poledne, R

“…The aim of the study was to ascertain whether the A-204C polymorphism in the cholesterol 7-hydroxylase (CYP7A1) gene plays any role in determining…”
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MTHFR and HFE, but not preproghrelin and LBP, polymorphisms as risk factors for all-cause end-stage renal disease development by Bloudíčková, S, Kuthanová, L, Hubáček, J A

“…End-stage renal disease (ESRD) is a serious health problem worldwide. The high prevalence of cardiovascular diseases and chronic inflammation remains a major…”
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Strong Association between APOA5 Gene Polymorphisms and Hypertriglyceridaemic Episodes by Vrablik, M, Hubacek, J A, Dlouha, D, Satny, M, Adamkova, V, Ceska, R

“…Plasma triglyceride (TG) levels represent a significant risk factor of cardiovascular and total mortality. Concentrations of TG in the plasma depend, to a…”
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Can Leukocyte Telomere Length Predict Survival Time in Heart Transplant Recipients over a Minimal Follow-Up of 20 years? by Dlouhá, D, Vančura, V, Vymětalová, J, Hubáček, J A, Lánská, V, Málek, I

“…In humans, leukocyte telomere length (LTL) reduces with age and is reported to be inversely associated with ageing-related diseases. We measured LTL in…”
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Association of metabolic and genetic factors with cholesterol esterification rate in HDL plasma and atherogenic index of plasma in a 40 years old Slovak population by Rašlová, K, Dobiášová, M, Hubáček, J A, Bencová, D, Siváková, D, Danková, Z, Franeková, J, Jabor, A, Gašparovič, J, Vohnout, B

“…We assessed association between novel biomarkers of cardiovascular disease and conventional factors in 40 years old subjects (208 men and 266 women) from the…”
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