Search Results - "Huang, Zaohua"

A CRISPR/Cas9 guidance RNA screen platform for HIV provirus disruption and HIV/AIDS gene therapy in astrocytes by Huang, Zaohua, Nair, Madahavan

“…HIV/AIDS remains a major health threat despite significant advances in the prevention and treatment of HIV infection. The major reason is the inability of…”
Get full text

Insulin-Like 3 Signaling Is Important for Testicular Descent but Dispensable for Spermatogenesis and Germ Cell Survival in Adult Mice by ZAOHUA HUANG, RIVAS, Bryan, AGOULNIK, Alexander I

“…Relaxin family peptide receptor 2 (RXFP2) is the cognate receptor of a peptide hormone insulin-like 3 (INSL3). INSL3 is expressed at high levels in both fetal…”
Get full text

Magnetically guided central nervous system delivery and toxicity evaluation of magneto-electric nanocarriers by Kaushik, Ajeet, Jayant, Rahul D., Nikkhah-Moshaie, Roozbeh, Bhardwaj, Vinay, Roy, Upal, Huang, Zaohua, Ruiz, Ariel, Yndart, Adriana, Atluri, Venkata, El-Hage, Nazira, Khalili, Kamel, Nair, Madhavan

“…Least component-based delivery of drug-tagged-nanocarriers across blood-brain-barriers (BBB) will allow site-specific and on-demand release of therapeutics to…”
Get full text

NOTCH1 gain of function in germ cells causes failure of spermatogenesis in male mice by Huang, Zaohua, Rivas, Bryan, Agoulnik, Alexander I

“…NOTCH1 is a member of the NOTCH receptor family, a group of single-pass trans-membrane receptors. NOTCH signaling is highly conserved in evolution and mediates…”
Get full text

Sperm function, protein phosphorylation, and metabolism differ in mice lacking successive sperm-specific glycolytic enzymes by Huang, Zaohua, Danshina, Polina V, Mohr, Kathleen, Qu, Weidong, Goodson, Summer G, O’Connell, Thomas M, O’Brien, Deborah A

“…Abstract Glyceraldehyde 3-phosphate dehydrogenase-S (GAPDHS) and phosphoglycerate kinase 2 (PGK2), two isozymes restricted to the male germline, catalyze…”
Get full text

Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1 by Xiao, Jingbo, Huang, Zaohua, Chen, Catherine Z., Agoulnik, Irina U., Southall, Noel, Hu, Xin, Jones, Raisa E., Ferrer, Marc, Zheng, Wei, Agoulnik, Alexander I., Marugan, Juan J.

“…The anti-fibrotic, vasodilatory and pro-angiogenic therapeutic properties of recombinant relaxin peptide hormone have been investigated in several diseases,…”
Get full text

Increased phosphorylation of a distinct subcellular pool of protein phosphatase, PP1γ2, during epididymal sperm maturation by ZAOHUA HUANG, VIJAYARAGHAVAN, Srinivasan

Get full text

Development of Multifunctional Biopolymeric Auto-Fluorescent Micro- and Nanogels as a Platform for Biomedical Applications by Vashist, Arti, Atluri, Venkata, Raymond, Andrea, Kaushik, Ajeet, Parira, Tiyash, Huang, Zaohua, Durygin, Andriy, Tomitaka, Asahi, Nikkhah-Moshaie, Roozbeh, Vashist, Atul, Agudelo, Marisela, Chand, Hitendra S, Saytashev, Ilyas, Ramella-Roman, Jessica C, Nair, Madhavan

“…The emerging field of theranostics for advanced healthcare has raised the demand for effective and safe delivery systems consisting of therapeutics and…”
Get full text

Characterization of UMi028-A-1 stem cell line that contains a CRISPR/Cas9 induced hearing loss-associated variant (V60L (c.178G > T)) in the P2RX2 gene by Gosstola, Nicholas C., Huang, Zaohua, Tong, Xiaoying, Nourbakhsh, Aida, Chen, Zheng-Yi, Dykxhoorn, Derek M., Zhong Liu, Xue

“…UMi028-A-1 hiPSC line contains a CRISPR/Cas9-induced heterozygous, hearing loss-associated variant (V60L (GTA > TTA)) in the Purinergic Receptor P2X2 (P2RX2)…”
Get full text

Insulin-Like 3 Signaling Is Important for Testicular Descent but Dispensable for Spermatogenesis and Germ Cell Survival in Adult Mice1 by Huang, Zaohua, Rivas, Bryan, Agoulnik, Alexander I

“…Relaxin family peptide receptor 2 (RXFP2) is the cognate receptor of a peptide hormone insulin-like 3 (INSL3). INSL3 is expressed at high levels in both fetal…”
Get full text

Protein 14-3-3ζ binds to protein phosphatase PP1γ2 in bovine epididymal spermatozoa by ZAOHUA HUANG, MYERS, Kimberley, KHATRA, Balwant, VIJAYARAGHAVAN, Srinivasan

Get full text

Activation of Relaxin Family Receptor 1 from Different Mammalian Species by Relaxin Peptide and Small-Molecule Agonist ML290 by Huang, Zaohua, Myhr, Courtney, Bathgate, Ross A D, Ho, Brian A, Bueno, Amaya, Hu, Xin, Xiao, Jingbo, Southall, Noel, Barnaeva, Elena, Agoulnik, Irina U, Marugan, Juan J, Ferrer, Marc, Agoulnik, Alexander I

“…Relaxin peptide (RLN), which signals through the relaxin family peptide 1 (RXFP1) GPCR receptor, has shown therapeutic effects in an acute heart failure…”
Get full text

Changes in intracellular distribution and activity of protein phosphatase PP1γ2 and its regulating proteins in spermatozoa lacking AKAP4 by ZAOHUA HUANG, SOMANATH, Payaningal R, CHAKRABARTI, Rumela, EDDY, Edward M, VIJAYARAGHAVAN, Srinivasan

Get full text

Sperm PP1γ2 is regulated by a homologue of the yeast protein phosphatase binding protein sds22 by ZAOHUA HUANG, KHATRA, Balwant, BOLLEN, Mathieu, CARR, Daniel W, VIJAYARAGHAVAN, Srinivasan

Get full text

Binding and inactivation of the germ cell-specific protein phosphatase PP1γ2 by sds22 during epididymal sperm maturation by MISHRA, Sanjay, SOMANATH, Payaningal R, ZAOHUA HUANG, VIJAYARAGHAVAN, Srinivasan

Get full text

AKAP3 Selectively Binds PDE4A Isoforms in Bovine Spermatozoa by BAJPAI, Malini, FIEDLER, Sarah E, ZAOHUA HUANG, VIJAYARAGHAVAN, Srinivasan, OLSON, Gary E, LIVERA, Gabriel, CONTI, Marco, CARR, Daniel W

“…Cyclic AMP plays an important role in regulating sperm motility and acrosome reaction through activation of cAMP-dependent protein kinase A (PKA)…”
Get full text

Increased Phosphorylation of a Distinct Subcellular Pool of Protein Phosphatase, PP1γ2, During Epididymal Sperm Maturation1 by Huang, Zaohua, Vijayaraghavan, Srinivasan

“…The enzyme PP1γ2 is a testis- and sperm-specific isoform of type 1 protein phosphatase (PP1), and it is the only isoform of PP1 in spermatozoa. The enzyme…”
Get full text

Hybrid magneto-plasmonic liposomes for multimodal image-guided and brain-targeted HIV treatment by Tomitaka, Asahi, Arami, Hamed, Huang, Zaohua, Raymond, Andrea, Rodriguez, Elizette, Cai, Yong, Febo, Marcelo, Takemura, Yasushi, Nair, Madhavan

“…Image-guided drug delivery is an emerging strategy in the field of nanomedicine. The addition of image guidance to a traditional drug delivery system is…”
Get more information

Changes in Intracellular Distribution and Activity of Protein Phosphatase PP1γ2 and Its Regulating Proteins in Spermatozoa Lacking AKAP41 by Huang, Zaohua, Somanath, Payaningal R, Chakrabarti, Rumela, Eddy, Edward M, Vijayaraghavan, Srinivasan

“…The second messenger cAMP mediates its intracellular effects in spermatozoa through cAMP-dependent kinase (PKA, formally known as PRKACA). The intracellular…”
Get full text

AKAP3 Selectively Binds PDE4A Isoforms in Bovine Spermatozoa1 by Bajpai, Malini, Fiedler, Sarah E, Huang, Zaohua, Vijayaraghavan, Srinivasan, Olson, Gary E, Livera, Gabriel, Conti, Marco, Carr, Daniel W

“…Cyclic AMP plays an important role in regulating sperm motility and acrosome reaction through activation of cAMP-dependent protein kinase A (PKA)…”
Get full text