Search Results - "Huang, Yunyuan"

N‑Acylamino Saccharin as an Emerging Cysteine-Directed Covalent Warhead and Its Application in the Identification of Novel FBPase Inhibitors toward Glucose Reduction by Wen, Wuqiang, Cao, Hongxuan, Xu, Yixiang, Ren, Yanliang, Rao, Li, Shao, Xubo, Chen, Han, Wu, Lixia, Liu, Jiaqi, Su, Chen, Peng, Chao, Huang, Yunyuan, Wan, Jian

“…With a resurgence of covalent drugs, there is an urgent need for the identification of new moieties capable of cysteine bond formation. Herein, we report on…”
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Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis by Wen, Wuqiang, Cao, Hongxuan, Huang, Yunyuan, Tu, Jie, Wan, Chen, Wan, Jian, Han, Xinya, Chen, Han, Liu, Jiaqi, Rao, Li, Su, Chen, Peng, Chao, Sheng, Chunquan, Ren, Yanliang

“…Fructose-1,6-bisphosphate aldolase (FBA) represents an attractive new antifungal target. Here, we employed a structure-based optimization strategy to discover…”
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Specific tracking of monoamine oxidase A in heart failure models by a far-red fluorescent probe with an ultra large Stokes shift by Li, Xinming, Shi, Donglei, Song, Yihe, Xu, Yixiang, Gao, Ying, Qiu, Wenjing, Chen, Xin, Li, Xiaokang, Huang, Yunyuan, Feng, Yanjun, Li, Baoli, Guo, Yuan, Li, Jian

“…Monoamine oxidase A (MAO-A) is a prominent myocardial source of reactive oxygen species (ROS), and its expression and activity are strongly increased in…”
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Anti-aging effects of chlorpropamide depend on mitochondrial complex-II and the production of mitochondrial reactive oxygen species by Mao, Zhifan, Liu, Wenwen, Huang, Yunyuan, Sun, Tianyue, Bao, Keting, Feng, Jiali, Moskalev, Alexey, Hu, Zelan, Li, Jian

“…Sulfonylureas are widely used oral anti-diabetic drugs. However, its long-term usage effects on patients’ lifespan remain controversial, with no reports of…”
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A Senomorphlytic Three-Drug Combination Discovered in Salsola collina for Delaying Aging Phenotypes and Extending Healthspan by Wang, Jiqun, Liu, Wenwen, Huang, Yunyuan, Wang, Guangwei, Guo, Xiaobo, Shi, Donglei, Sun, Tianyue, Xiao, Chaojiang, Zhang, Chao, Jiang, Bei, Guo, Yuan, Li, Jian

“…The pursuit of pharmacological interventions in aging aims focuses on maximizing safety and efficacy, prompting an exploration of natural products endowed with…”
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Structural repurposing of SGLT2 inhibitor empagliflozin for strengthening anti-heart failure activity with lower glycosuria by Xu, Yixiang, Zhang, Chao, Jiang, Kai, Yang, Xinchun, Chen, Feng, Cheng, Zhiyang, Zhao, Jinlong, Cheng, Jiaxing, Li, Xiaokang, Chen, Xin, Zhou, Luoyifan, Duan, Hao, Huang, Yunyuan, Xiang, Yaozu, Li, Jian

“…Sodium-glucose cotransporter 2 (SGLT2) inhibitors have been reapproved for heart failure (HF) therapy in patients with and without diabetes. However, the…”
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Advances in inhibitor development targeting the PWWP domain by Huang, Yunyuan, Li, Yanxi, Min, Jinrong

“…The PWWP domain binds to both histone and DNA of a nucleosome in a bivalent way. PWWP domain-containing proteins are involved in different biological…”
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Inhibitors targeting the PWWP domain-containing proteins by Huang, Yunyuan, Li, Boyi, Wu, Zhibin, Liu, Ke, Min, Jinrong

“…PWWP domain-containing proteins play a pivotal role in chromatin-mediated biological processes, and their aberrant regulation is linked to various human…”
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N/C-degron pathways and inhibitor development for PROTAC applications by Wu, Zhibin, Huang, Yunyuan, Liu, Ke, Min, Jinrong

“…Ubiquitination is a fascinating post-translational modification that has received continuous attention since its discovery. In this review, we first provide a…”
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Novel Combination Therapy for Heart Failure: Trimebutine–Methoxsalen Identified through Synergistic Network Virtual Screening and Experimental Validation by Huang, Yunyuan, Chen, Xin, Yang, Jin, Yao, Yue, Wang, Manjiong, Lu, Taotao, Li, Xiao, Wang, Jiqun, Qiao, Sicong, Shi, Donglei, Li, Xiaokang, Li, Jian, Xu, Yixiang

“…Combination therapy is increasingly favored by pharmaceutical companies and researchers as an effective way to quickly discover new drugs with excellent…”
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Cov_FB3D: A De Novo Covalent Drug Design Protocol Integrating the BA-SAMP Strategy and Machine-Learning-Based Synthetic Tractability Evaluation by Wei, Lin, Wen, Wuqiang, Rao, Li, Huang, Yunyuan, Lei, Mengting, Liu, Kai, Hu, Saiya, Song, Rongrong, Ren, Yanliang, Wan, Jian

“…De novo drug design actively seeks to use sets of chemical rules for the fast and efficient identification of structurally new chemotypes with the desired set…”
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Discovery of novel dual RAGE/SERT inhibitors for the potential treatment of the comorbidity of Alzheimer's disease and depression by Zhang, Chao, Wang, Lan, Xu, Yixiang, Huang, Yunyuan, Huang, Junyang, Zhu, Jin, Wang, Wei, Li, Wangsheng, Sun, Annan, Li, Xiaokang, Zhang, Haiyan, Li, Jian

“…Depression is identified as one of the most common psychiatric symptoms in Alzheimer's disease (AD). The comorbidity of AD and depression increases the burden…”
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Rapid Repurposing of Novel Combination Drugs for the Treatment of Heart Failure via a Computationally Guided Network Screening Approach by Huang, Yunyuan, Wang, Jiqun, Liu, Jiaqi, Shi, Donglei, Li, Xiaokang, Wang, Manjiong, Lu, Taotao, Jiang, Bei, Xia, Conglong, Lin, Houwen, Xu, Yixiang, Li, Jian

“…Combination drugs, characterized by high efficacy and few side effects, have received extensive attention from pharmaceutical companies and researchers for the…”
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Discovery of novel allosteric site and covalent inhibitors of FBPase with potent hypoglycemic effects by Huang, Yunyuan, Wei, Lin, Han, Xinya, Chen, Haifeng, Ren, Yanliang, Xu, Yanhong, Song, Rongrong, Rao, Li, Su, Chen, Peng, Chao, Feng, Lingling, Wan, Jian

“…Fructose-1,6-bisphosphatase (FBPase) is an essential enzyme of GNG pathway. Significant advances demonstrate the FBPase plays a critical role in treatment of…”
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Identification of the New Covalent Allosteric Binding Site of Fructose-1,6-bisphosphatase with Disulfiram Derivatives toward Glucose Reduction by Huang, Yunyuan, Xu, Yixiang, Song, Rongrong, Ni, Shuaishuai, Liu, Jiaqi, Xu, Yanhong, Ren, Yanliang, Rao, Li, Wang, Yingjie, Wei, Lin, Feng, Lingling, Su, Chen, Peng, Chao, Li, Jian, Wan, Jian

“…Fructose 1,6-bisphosphatase (FBPase) has attracted substantial interest as a target associated with cancer and type 2 diabetes. Herein, we found that…”
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Photoactivatable senolysis with single-cell resolution delays aging by Shi, Donglei, Liu, Wenwen, Gao, Ying, Li, Xinming, Huang, Yunyuan, Li, Xiaokang, James, Tony D, Guo, Yuan, Li, Jian

“…Strategies that can selectively eliminate senescent cells (SnCs), namely senolytics, have been shown to promote healthy lifespan. However, it is challenging to…”
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The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression by Li, Xiaokang, Li, Jinwen, Huang, Yunyuan, Gong, Qi, Fu, Yan, Xu, Yixiang, Huang, Junyang, You, Haolan, Zhang, Dong, Zhang, Dan, Mao, Fei, Zhu, Jin, Wang, Huan, Zhang, Haiyan, Li, Jian

“…Depression is one of the most frequent comorbid psychiatric symptoms of Alzheimer's disease (AD), and no efficacious drugs have been approved specifically for…”
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Biological evaluation and SAR analysis of novel covalent inhibitors against fructose-1,6-bisphosphatase by Han, Xinya, Huang, Yunyuan, Wei, Lin, Chen, Haifeng, Guo, Yanrong, Tang, Zilong, Hu, Wei, Xia, Qinfei, Wang, Qi, Yan, Jufen, Ren, Yanliang

“…[Display omitted] Fructose-1,6-bisphosphatase (FBPase) is an attractive target for affecting the GNG pathway. In our previous study, the C128 site of FBPase…”
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Nicandra physalodes Extract Exerts Antiaging Effects in Multiple Models and Extends the Lifespan of Caenorhabditis elegans via DAF-16 and HSF-1 by Wang, Jiqun, Huang, Yunyuan, Shi, Kaixuan, Bao, Lingyuan, Xiao, Chaojiang, Sun, Tianyue, Mao, Zhifan, Feng, Jiali, Hu, Zelan, Guo, Zhenghan, Li, Jing, Jiang, Bei, Liu, Wenwen, Li, Jian

“…The development of safe and effective therapeutic interventions is an important issue for delaying aging and reducing the risk of aging-related diseases…”
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Identification of Guaifenesin–Andrographolide as a Novel Combinatorial Drug Therapy for Epilepsy Using Network Virtual Screening and Experimental Validation by Huang, Yunyuan, Xu, Haiyan, Wang, Pei, Gu, Rurong, Li, Xiaokang, Xu, Yixiang, Wang, Jiqun, Qiao, Sicong, Shi, Donglei, Gao, Zhaobing, Li, Jian

“…Combinatorial drug therapy has attracted substantial attention as an emerging strategy for the treatment of diseases with complex pathological mechanisms. We…”
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