Search Results - "Huang, Yinghui Jane"

1016 Enforcement of exhausted T cell epigenetic fate by HMG-box transcription factor TOX by Huang, Yinghui Jane, Giles, Josephine R, Ngiow, Shin Foong, Baxter, Amy E, Manne, Sasikanth, Khan, Omar, Park, Simone L, Wu, Jennifer E, John Wherry, E

“…BackgroundT cell exhaustion is one of the major barriers limiting efficacious anti-tumor therapy. Exhausted CD8 T cells (TEX) develop following persistent…”
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Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms by Beltra, Jean-Christophe, Manne, Sasikanth, Abdel-Hakeem, Mohamed S., Kurachi, Makoto, Giles, Josephine R., Chen, Zeyu, Casella, Valentina, Ngiow, Shin Foong, Khan, Omar, Huang, Yinghui Jane, Yan, Patrick, Nzingha, Kito, Xu, Wei, Amaravadi, Ravi K., Xu, Xiaowei, Karakousis, Giorgos C., Mitchell, Tara C., Schuchter, Lynn M., Huang, Alexander C., Wherry, E. John

“…CD8+ T cell exhaustion is a major barrier to current anti-cancer immunotherapies. Despite this, the developmental biology of exhausted CD8+ T cells (Tex)…”
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Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications by Mathew, Divij, Giles, Josephine R, Baxter, Amy E, Oldridge, Derek A, Greenplate, Allison R, Wu, Jennifer E, Alanio, Cécile, Kuri-Cervantes, Leticia, Pampena, M Betina, D'Andrea, Kurt, Manne, Sasikanth, Chen, Zeyu, Huang, Yinghui Jane, Reilly, John P, Weisman, Ariel R, Ittner, Caroline A G, Kuthuru, Oliva, Dougherty, Jeanette, Nzingha, Kito, Han, Nicholas, Kim, Justin, Pattekar, Ajinkya, Goodwin, Eileen C, Anderson, Elizabeth M, Weirick, Madison E, Gouma, Sigrid, Arevalo, Claudia P, Bolton, Marcus J, Chen, Fang, Lacey, Simon F, Ramage, Holly, Cherry, Sara, Hensley, Scott E, Apostolidis, Sokratis A, Huang, Alexander C, Vella, Laura A, Betts, Michael R, Meyer, Nuala J, Wherry, E John

“…Coronavirus disease 2019 (COVID-19) is currently a global pandemic, but human immune responses to the virus remain poorly understood. We used high-dimensional…”
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Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics by Giles, Josephine R., Ngiow, Shin Foong, Manne, Sasikanth, Baxter, Amy E., Khan, Omar, Wang, Ping, Staupe, Ryan, Abdel-Hakeem, Mohamed S., Huang, Hua, Mathew, Divij, Painter, Mark M., Wu, Jennifer E., Huang, Yinghui Jane, Goel, Rishi R., Yan, Patrick K., Karakousis, Giorgos C., Xu, Xiaowei, Mitchell, Tara C., Huang, Alexander C., Wherry, E. John

“…Naïve CD8 + T cells can differentiate into effector (T eff ), memory (T mem ) or exhausted (T ex ) T cells. These developmental pathways are associated with…”
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LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity by Ngiow, Shin Foong, Manne, Sasikanth, Huang, Yinghui Jane, Azar, Tarek, Chen, Zeyu, Mathew, Divij, Chen, Qingzhou, Khan, Omar, Wu, Jennifer E, Alcalde, Victor, Flowers, Ahron J, McClain, Sean, Baxter, Amy E, Kurachi, Makoto, Shi, Junwei, Huang, Alexander C, Giles, Josephine R, Sharpe, Arlene H, Vignali, Dario A A, Wherry, E John

“…Exhausted CD8 T (T ) cells in chronic viral infection and cancer have sustained co-expression of inhibitory receptors (IRs). T cells can be reinvigorated by…”
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Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19 by Vella, Laura A, Giles, Josephine R, Baxter, Amy E, Oldridge, Derek A, Diorio, Caroline, Kuri-Cervantes, Leticia, Alanio, Cécile, Pampena, M Betina, Wu, Jennifer E, Chen, Zeyu, Huang, Yinghui Jane, Anderson, Elizabeth M, Gouma, Sigrid, McNerney, Kevin O, Chase, Julie, Burudpakdee, Chakkapong, Lee, Jessica H, Apostolidis, Sokratis A, Huang, Alexander C, Mathew, Divij, Kuthuru, Oliva, Goodwin, Eileen C, Weirick, Madison E, Bolton, Marcus J, Arevalo, Claudia P, Ramos, Andre, Jasen, C J, Conrey, Peyton E, Sayed, Samir, Giannini, Heather M, D'Andrea, Kurt, Meyer, Nuala J, Behrens, Edward M, Bassiri, Hamid, Hensley, Scott E, Henrickson, Sarah E, Teachey, David T, Betts, Michael R, Wherry, E John

“…Pediatric COVID-19 following SARS-CoV-2 infection is associated with fewer hospitalizations and often milder disease than in adults. A subset of children,…”
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LAG-3 and PD-1 synergize on CD8 + T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity by Andrews, Lawrence P, Butler, Samuel C, Cui, Jian, Cillo, Anthony R, Cardello, Carly, Liu, Chang, Brunazzi, Erin A, Baessler, Andrew, Xie, Bingxian, Kunning, Sheryl R, Ngiow, Shin Foong, Huang, Yinghui Jane, Manne, Sasikanth, Sharpe, Arlene H, Delgoffe, Greg M, Wherry, E John, Kirkwood, John M, Bruno, Tulia C, Workman, Creg J, Vignali, Dario A A

“…Overcoming immune-mediated resistance to PD-1 blockade remains a major clinical challenge. Enhanced efficacy has been demonstrated in melanoma patients with…”
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A role for the transcription factor STAT5 in antagonizing CD8+ T cell exhaustion by Beltra, Jean-Christophe, Manne, Sasikanth, Abdel-Hakeem, Mohamed S, Nzingha, Kito, Zhang, Zhen, Huang, Hua, Kurachi, Makoto, Muroyama, Yuki, Huang, Yinghui Jane, Su, Leon L, Picton, Lora, Decaluwe, Helene, Huang, Alexander C, Berger, Shelley L, Garcia, Christopher K, Wherry, E. John

“…Abstract Exhaustion gradually establishes in chronically stimulated CD8s and this process is not reverted by current therapeutic approaches due to…”
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Developmental relationships of four exhausted CD8 T cell subsets reveals underlying transcriptional and epigenetic control mechanisms by Beltra, Jean-Christophe, Manne, Sasikanth, Hakeem, Mohamed S Abdel, Kurachi, Makoto, Giles, Josephine R, Chen, Zeyu, Casella, Valentina, Ngiow, Shin, Khan, Omar, Huang, Yinghui Jane, Yan, Patrick, Nzingha, Kito, Huang, Alexander C., Wherry, E. John

“…Abstract Exhausted CD8 T cells (TEX) are essential during chronic viral infections and cancer. Two TEX subpopulations including a progenitor and a more…”
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Signaling Through FcγRIIA and the C5a-C5aR Pathway Mediate Platelet Hyperactivation in COVID-19 by Apostolidis, Sokratis A, Sarkar, Amrita, Giannini, Heather M, Goel, Rishi R, Mathew, Divij, Suzuki, Aae, Baxter, Amy E, Greenplate, Allison R, Alanio, Cécile, Abdel-Hakeem, Mohamed, Oldridge, Derek A, Giles, Josephine R, Wu, Jennifer E, Chen, Zeyu, Huang, Yinghui Jane, Belman, Jonathan, Pattekar, Ajinkya, Manne, Sasikanth, Kuthuru, Oliva, Dougherty, Jeanette, Weiderhold, Brittany, Weisman, Ariel R, Ittner, Caroline A G, Gouma, Sigrid, Dunbar, Debora, Frank, Ian, Huang, Alexander C, Vella, Laura A, Reilly, John P, Hensley, Scott E, Rauova, Lubica, Zhao, Liang, Meyer, Nuala J, Poncz, Mortimer, Abrams, Charles S, Wherry, E John

“…Patients with COVID-19 present with a wide variety of clinical manifestations. Thromboembolic events constitute a significant cause of morbidity and mortality…”
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Abstract 1811: Evaluation of anti-CXCR2 small molecule inhibitors as novel chemotherapy targeting the Interleukin-8 pathway in colorectal cancer by Huang, Yinghui Jane E., Gaffney, Kevin J., Gerdts, Ethan, Petasis, Nicos A., Lenz, Heinz-Josef, LaBonte, Melissa J.

“…Abstract Despite new and improved chemotherapy treatments for colorectal cancer (CRC) contributing to enhanced treatment response rates and patient prognosis,…”
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