Search Results - "Huang, Yanhua H"

Bidirectional Modulation of Incubation of Cocaine Craving by Silent Synapse-Based Remodeling of Prefrontal Cortex to Accumbens Projections by Ma, Yao-Ying, Lee, Brian R., Wang, Xiusong, Guo, Changyong, Liu, Lei, Cui, Ranji, Lan, Yan, Balcita-Pedicino, Judith J., Wolf, Marina E., Sesack, Susan R., Shaham, Yavin, Schlüter, Oliver M., Huang, Yanhua H., Dong, Yan

“…Glutamatergic projections from the medial prefrontal cortex (mPFC) to nucleus accumbens (NAc) contribute to cocaine relapse. Here we show that silent…”
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Opposing mechanisms mediate morphine- and cocaine-induced generation of silent synapses by Graziane, Nicholas M, Sun, Shichao, Wright, William J, Jang, Daniel, Liu, Zheng, Huang, Yanhua H, Nestler, Eric J, Wang, Yu Tian, Schlüter, Oliver M, Dong, Yan

“…Cocaine and morphine produce similar addiction-related behaviors, but different adaptations at accumbens synapses. The authors explain this paradox, showing…”
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Silent synapses dictate cocaine memory destabilization and reconsolidation by Wright, William J., Graziane, Nicholas M., Neumann, Peter A., Hamilton, Peter J., Cates, Hannah M., Fuerst, Lauren, Spenceley, Alexander, MacKinnon-Booth, Natalie, Iyer, Kartik, Huang, Yanhua H., Shaham, Yavin, Schlüter, Oliver M., Nestler, Eric J., Dong, Yan

“…Cocaine-associated memories are persistent, but, on retrieval, become temporarily destabilized and vulnerable to disruptions, followed by reconsolidation. To…”
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Neuropathic pain generates silent synapses in thalamic projection to anterior cingulate cortex by Wang, Yao Q., Wang, Junshi, Xia, Sun-hui, Gutstein, Howard B., Huang, Yanhua H., Schlüter, Oliver M., Cao, Jun-Li, Dong, Yan

“…Pain experience can change the central processing of nociceptive inputs, resulting in persistent allodynia and hyperalgesia. However, the underlying circuit…”
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Astrocyte Molecular Clock Function in the Nucleus Accumbens Is Important for Reward-Related Behavior by Becker-Krail, Darius D., Ketchesin, Kyle D., Burns, Jennifer N., Zong, Wei, Hildebrand, Mariah A., DePoy, Lauren M., Vadnie, Chelsea A., Tseng, George C., Logan, Ryan W., Huang, Yanhua H., McClung, Colleen A.

“…Substance use disorders are associated with disruptions in circadian rhythms. Both human and animal work have shown the integral role for circadian clocks in…”
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Selective presynaptic enhancement of the prefrontal cortex to nucleus accumbens pathway by cocaine by Suska, Anna, Lee, Brian R., Huang, Yanhua H., Dong, Yan, Schlüter, Oliver M.

“…The nucleus accumbens (NAc) regulates motivated behavior by, in part, processing excitatory synaptic projections from several brain regions. Among these…”
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Neural deficits in a mouse model of PACS1 syndrome are corrected with PACS1- or HDAC6-targeting therapy by Villar-Pazos, Sabrina, Thomas, Laurel, Yang, Yunhan, Chen, Kun, Lyles, Jenea B., Deitch, Bradley J., Ochaba, Joseph, Ling, Karen, Powers, Berit, Gingras, Sebastien, Kordasiewicz, Holly B., Grubisha, Melanie J., Huang, Yanhua H., Thomas, Gary

“…PACS1 syndrome is a neurodevelopmental disorder (NDD) caused by a recurrent de novo missense mutation in PACS1 (p.Arg203Trp (PACS1 R203W )). The mechanism by…”
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Sleep: a synchrony of cell activity-driven small network states by Krueger, James M., Huang, Yanhua H., Rector, David M., Buysse, Daniel J.

“…We posit a bottom‐up sleep‐regulatory paradigm in which state changes are initiated within small networks as a consequence of local cell activity. Bottom‐up…”
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The density of EAAC1 (EAAT3) glutamate transporters expressed by neurons in the mammalian CNS by Holmseth, Silvia, Dehnes, Yvette, Huang, Yanhua H, Follin-Arbelet, Virginie V, Grutle, Nina J, Mylonakou, Maria N, Plachez, Celine, Zhou, Yun, Furness, David N, Bergles, Dwight E, Lehre, Knut P, Danbolt, Niels C

“…The extracellular levels of excitatory amino acids are kept low by the action of the glutamate transporters. Glutamate/aspartate transporter (GLAST) and…”
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Cue- versus reward-encoding basolateral amygdala projections to nucleus accumbens by He, Yi, Huang, Yanhua H, Schlüter, Oliver M, Dong, Yan

“…In substance use disorders, drug use as unconditioned stimulus (US) reinforces drug taking. Meanwhile, drug-associated cues (conditioned stimulus [CS]) also…”
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Temporal dynamics of nucleus accumbens neurons in male mice during reward seeking by Schall, Terra A., Li, King-Lun, Qi, Xiguang, Lee, Brian T., Wright, William J., Alpaugh, Erin E., Zhao, Rachel J., Liu, Jianwei, Li, Qize, Zeng, Bo, Wang, Lirong, Huang, Yanhua H., Schlüter, Oliver M., Nestler, Eric J., Nieh, Edward H., Dong, Yan

“…The nucleus accumbens (NAc) regulates reward-motivated behavior, but the temporal dynamics of NAc neurons that enable “free-willed” animals to obtain rewards…”
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Cell-Type-Specific Regulation of Nucleus Accumbens Synaptic Plasticity and Cocaine Reward Sensitivity by the Circadian Protein, NPAS2 by Parekh, Puja K, Logan, Ryan W, Ketchesin, Kyle D, Becker-Krail, Darius, Shelton, Micah A, Hildebrand, Mariah A, Barko, Kelly, Huang, Yanhua H, McClung, Colleen A

“…The circadian transcription factor neuronal PAS domain 2 (NPAS2) is linked to psychiatric disorders associated with altered reward sensitivity. The expression…”
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In Vivo Cocaine Experience Generates Silent Synapses by Huang, Yanhua H., Lin, Ying, Mu, Ping, Lee, Brian R., Brown, Travis E., Wayman, Gary, Marie, Helene, Liu, Wenhua, Yan, Zhen, Sorg, Barbara A., Schlüter, Oliver M., Zukin, R. Suzanne, Dong, Yan

“…Studies over the past decade have enunciated silent synapses as prominent cellular substrates for synaptic plasticity in the developing brain. However, little…”
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A silent synapse-based mechanism for cocaine-induced locomotor sensitization by Brown, Travis E, Lee, Brian R, Mu, Ping, Ferguson, Deveroux, Dietz, David, Ohnishi, Yoshinori N, Lin, Ying, Suska, Anna, Ishikawa, Masago, Huang, Yanhua H, Shen, Haowei, Kalivas, Peter W, Sorg, Barbara A, Zukin, R Suzanne, Nestler, Eric J, Dong, Yan, Schlüter, Oliver M

“…Locomotor sensitization is a common and robust behavioral alteration in rodents whereby following exposure to abused drugs such as cocaine, the animal becomes…”
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Glutamate transporters bring competition to the synapse by Huang, Yanhua H, Bergles, Dwight E

“…Glutamate transporters (GluTs) prevent the accumulation of glutamate and influence the occupancy of receptors at synapses. The ability of extrasynaptic NMDA…”
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Cannabinoid receptor 1-expressing neurons in the nucleus accumbens by Winters, Bradley D., Krüger, Juliane M., Huang, Xiaojie, Gallaher, Zachary R., Ishikawa, Masago, Czaja, Krzysztof, Krueger, James M., Huang, Yanhua H., Schlüter, Oliver M., Dong, Yan

“…Endocannabinoid signaling critically regulates emotional and motivational states via activation of cannabinoid receptor 1 (CB1) in the brain. The nucleus…”
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Zones of enhanced glutamate release from climbing fibers in the mammalian cerebellum by Paukert, Martin, Huang, Yanhua H, Tanaka, Kohichi, Rothstein, Jeffrey D, Bergles, Dwight E

“…Purkinje cells in the mammalian cerebellum are remarkably homogeneous in shape and orientation, yet they exhibit regional differences in gene expression…”
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Cocaine-induced projection-specific and cell type-specific adaptations in the nucleus accumbens by Zinsmaier, Alexander K., Dong, Yan, Huang, Yanhua H.

“…Cocaine craving, seeking, and relapse are mediated, in part, by cocaine-induced adaptive changes in the brain reward circuits. The nucleus accumbens (NAc)…”
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An Unusual Suspect in Cocaine Addiction by Huang, Yanhua H., Schlüter, Oliver M., Dong, Yan

“…Development of drug addiction is extremely complex, but its initiation can be as simple as the flip-flop of glutamatergic receptor subtypes triggered by an…”
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Astrocyte Glutamate Transporters Regulate Metabotropic Glutamate Receptor-Mediated Excitation of Hippocampal Interneurons by Huang, Yanhua H, Sinha, Saurabh R, Tanaka, Kohichi, Rothstein, Jeffrey D, Bergles, Dwight E

“…Clearance of extracellular glutamate is essential for limiting the activity of metabotropic glutamate receptors (mGluRs) at excitatory synapses; however, the…”
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