Search Results - "Huang, Xiangao"

A phase 1 trial of ibrutinib plus palbociclib in previously treated mantle cell lymphoma by Martin, Peter, Bartlett, Nancy L., Blum, Kristie A., Park, Steven, Maddocks, Kami, Ruan, Jia, Ridling, LeAnn, Dittus, Christopher, Chen, Zhengming, Huang, Xiangao, Inghirami, Giorgio, DiLiberto, Maurizio, Chen-Kiang, Selina, Leonard, John P.

“…Single-agent ibrutinib is active in patients with previously treated mantle cell lymphoma (MCL); however, nearly half of all patients experience treatment…”
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Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance by Li, Fei, Wang, Yizhe, Hwang, Inah, Jang, Ja-Young, Xu, Libo, Deng, Zhong, Yu, Eun Young, Cai, Yiming, Wu, Caizhi, Han, Zhenbo, Huang, Yu-Han, Huang, Xiangao, Zhang, Ling, Yao, Jun, Lue, Neal F., Lieberman, Paul M., Ying, Haoqiang, Paik, Jihye, Zheng, Hongwu

“…Telomere length maintenance is essential for cellular immortalization and tumorigenesis. 5% − 10% of human cancers rely on a recombination-based mechanism…”
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A novel effect of thalidomide and its analogs: suppression of cereblon ubiquitination enhances ubiquitin ligase function by Liu, Yaobin, Huang, Xiangao, He, Xian, Zhou, Yanqing, Jiang, Xiaogang, Chen‐Kiang, Selina, Jaffrey, Samie R., Xu, Guoqiang

“…ABSTRACT The immunomodulatory drug (IMiD) thalidomide and its structural analogs lenalidomide and pomalidomide are highly effective in treating clinical…”
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A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas by Jang, Ja-Young, Hwang, Inah, Pan, Heng, Yao, Jun, Alinari, Lapo, Imada, Eddie, Zanettini, Claudio, Kluk, Michael J, Wang, Yizhe, Lee, Yunkyoung, Lin, Hua V, Huang, Xiangao, Di Liberto, Maurizio, Chen, Zhengming, Ballman, Karla V, Cantley, Lewis C, Marchionni, Luigi, Inghirami, Giorgio, Elemento, Olivier, Baiocchi, Robert A, Chen-Kiang, Selina, Belvedere, Sandro, Zheng, Hongwu, Paik, Jihye

“…Targeting lineage-defined transcriptional dependencies has emerged as an effective therapeutic strategy in cancer treatment. Through screening for molecular…”
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A phase I trial of palbociclib plus bortezomib in previously treated mantle cell lymphoma by Martin, Peter, Ruan, Jia, Furman, Richard, Rutherford, Sarah, Allan, John, Chen, Zhengming, Huang, Xiangao, DiLiberto, Maurizio, Chen-Kiang, Selina, Leonard, John P.

“…In mantle cell lymphoma (MCL), cyclin D1 combines with CDK4/6 to phosphorylate Rb, releasing a break on the G1 to S phase cell cycle. Palbociclib is a…”
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Prolonged early G1 arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle–coupled loss of IRF4 by Huang, Xiangao, Di Liberto, Maurizio, Jayabalan, David, Liang, Jun, Ely, Scott, Bretz, Jamieson, Shaffer, Arthur L., Louie, Tracey, Chen, Isan, Randolph, Sophia, Hahn, William C., Staudt, Louis M., Niesvizky, Ruben, Moore, Malcolm A.S., Chen-Kiang, Selina

“…Dysregulation of cyclin-dependent kinase 4 (CDK4) and CDK6 by gain of function or loss of inhibition is common in human cancer, including multiple myeloma, but…”
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A novel therapeutic combination using PD 0332991 and bortezomib: study in the 5T33MM myeloma model by Menu, Eline, Garcia, Josefina, Huang, Xiangao, Di Liberto, Maurizio, Toogood, Peter L, Chen, Isan, Vanderkerken, Karin, Chen-Kiang, Selina

“…Multiple myeloma (MM) remains incurable partly because no effective cell cycle-based therapy has been available to both control tumor cell proliferation and…”
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MAGE-A Inhibits Apoptosis in Proliferating Myeloma Cells through Repression of Bax and Maintenance of Survivin by NARDIELLO, Tricia, JUNGBLUTH, Achim A, PEARSE, Roger, COLEMAN, Morton, JAYABALAN, David S, BHARDWAJ, Nina, OLD, Lloyd J, CHEN-KIANG, Selina, HEARN JAY CHO, MEI, Anna, DILIBERTO, Maurizio, XIANGAO HUANG, DABROWSKI, Ania, ANDRADE, Valéria C. C, WASSERSTRUM, Rebecca, ELY, Scott, NIESVIZKY, Ruben

“…The type I Melanoma Antigen GEnes (MAGEs) are commonly expressed in cancers, fueling speculation that they may be therapeutic targets with oncogenic potential…”
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Caspase-8 Inhibition Prevents the Cleavage and Degradation of E3 Ligase Substrate Receptor Cereblon and Potentiates Its Biological Function by Zhou, Liang, Yu, Wenjun, Jayabalan, David S, Niesvizky, Ruben, Jaffrey, Samie R, Huang, Xiangao, Xu, Guoqiang

“…Cereblon (CRBN), a substrate receptor of cullin 4-RING E3 ligase (CRL4), mediates the ubiquitination and degradation of constitutive substrates and…”
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Noxa mediates p18INK4c cell-cycle control of homeostasis in B cells and plasma cell precursors by Bretz, Jamieson, Garcia, Josefina, Huang, Xiangao, Kang, Lin, Zhang, Yang, Toellner, Kai-Michael, Chen-Kiang, Selina

“…Inhibition of Cdk4/Cdk6 by p18INK4c (p18) is pivotal for generation of noncycling immunoglobulin (Ig)-secreting plasma cells (PCs). In the absence of p18,…”
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Caspase-8 Regulates the Antimyeloma Activity of Bortezomib and Lenalidomide by Zhou, Liang, Huang, Xiangao, Niesvizky, Ruben, Pu, Zhongjian, Xu, Guoqiang

“…Proteasome inhibitors and immunomodulatory drugs (IMiDs) are two major types of drugs for the treatment of multiple myeloma. Although different combination…”
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Blind reconnaissance of the pseudo-random sequence in DS/SS signal with negative SNR by Huang, XianGao, Huang, Wei, Wang, Chao, Lü, ZeJun, Hu, YanHua

“…This paper introduces a new theory and algorithm that can be used in blind detection of the carrier wave signal and the pseudo-random sequence of the direct…”
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Cell Cycle Dysregulation in Mantle Cell Lymphoma: Genomics and Therapy by Wang, Kevin, Huang, Xiangao, Di Liberto, Maurizio, Chen-Kiang, Selina

“…Cell cycle dysregulation caused by aberrant cyclin D1 and CDK4 expression is a major determinant for proliferation of cancer cells in mantle cell lymphoma…”
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Cell Cycle Dysregulation in Mantle Cell Lymphoma by Wang, Kevin, Huang, Xiangao, Di Liberto, Maurizio, Chen-Kiang, Selina

“…Cell cycle dysregulation caused by aberrant cyclin D1 and CDK4 expression is a major determinant for proliferation of cancer cells in mantle cell lymphoma…”
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Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal functional genomics in mantle cell lymphoma by Chiron, David, Di Liberto, Maurizio, Martin, Peter, Huang, Xiangao, Sharman, Jeff, Blecua, Pedro, Mathew, Susan, Vijay, Priyanka, Eng, Ken, Ali, Siraj, Johnson, Amy, Chang, Betty, Ely, Scott, Elemento, Olivier, Mason, Christopher E, Leonard, John P, Chen-Kiang, Selina

“…Despite the unprecedented clinical activity of the Bruton tyrosine kinase (BTK) inhibitor ibrutinib in mantle cell lymphoma (MCL), acquired resistance is…”
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Combined Inhibition of CDK2 and BCL2 Overrides Resistance to Targeting BTK and CDK4/6 in Mantle Cell Lymphoma Therapy by Al-Ansari, Haya Y., Bashir, Saira, Cui, Adrienne, Huang, Xiangao, Hu, Yang, Martin, Peter, Elemento, Olivier, Di Liberto, Maurizio, Chen-Kiang, Selina

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Homeostatic cell-cycle control by BLyS: Induction of cell-cycle entry but not G1/S transition in opposition to p18INK4c and p27Kip1 by Huang, Xiangao, Di Liberto, Maurizio, Cunningham, Adam F, Kang, Lin, Cheng, Shuhua, Ely, Scott, Liou, Hsiou-chi, Maclennan, Ian C M, Chen-Kiang, Selina

“…Cell-cycle entry is critical for homeostatic control in physiologic response of higher organisms but is not well understood. The antibody response begins with…”
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Disrupting GRINL1A Association with Cereblon Accelerates IKZF1/3 Degradation and IMiD Killing of Mantle Cell Lymphoma Cells By CDK4/6 Inhibition by Zhao, Nicole, Di Liberto, Maurizio, Elemento, Olivier, Chen-Kiang, Selina, Huang, Xiangao

“…Lenalidomide (Len) and Pomalidomide (Pom) are immunomodulatory drugs (IMiDs) used for the treatment of multiple myeloma (MM) and have efficacy in other…”
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Harnessing Btki Therapy By CDK4/6i Control of T Effector Memory Cells and T Cell Surveillance in Mantle Cell Lymphoma by Di Liberto, Maurizio, Hu, Yang, Huang, Xiangao, Inghirami, Giorgio, Wang, Kevin, Lee, Christina, Maddocks, Kami J., Blum, Kristie A., Ruan, Jia, Leonard, John P., Bartlett, Nancy L., Martin, Peter, Elemento, Olivier, Chen-Kiang, Selina

“…Drug resistance remains a formidable challenge in mantle cell lymphoma (MCL). Cell cycle dysregulation driven by aberrant Cyclin D1 and CDK4 expression is a…”
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Dynamic Immune Surveillance in Durable Clinical Response to Combined BTK and BCL2 Inhibition in MCL at Longitudinal Single-Cell Resolution by Wang, Kevin, Di Liberto, Maurizio, Hu, Yang, Huang, Xiangao, Koldej, Rachel M, Ritchie, David, Martin, Peter, Inghirami, Giorgio, Elemento, Olivier, Tam, Constantine S., Chen-Kiang, Selina

“…Combined inhibition of BTK with ibrutinib and BCL2 with venetoclax is one of the most promising therapies for B cell malignancies, especially mantle cell…”
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