Search Results - "Huang, Tian Lian"
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Lung Stem Cell Differentiation in Mice Directed by Endothelial Cells via a BMP4-NFATc1-Thrombospondin-1 Axis
Published in Cell (30-01-2014)“…Lung stem cells are instructed to produce lineage-specific progeny through unknown factors in their microenvironment. We used clonal 3D cocultures of…”
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1532-P: A Novel Light-Responsive Adipose–Hypothalamus Axis in Metabolic Regulation
Published in Diabetes (New York, N.Y.) (20-06-2023)“…Light plays an essential role in life. Animals and humans possess light-sensing photoreceptors in visual and non-visual organs. We and others recently showed a…”
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12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat
Published in Cell metabolism (01-10-2019)“…Distinct oxygenases and their oxylipin products have been shown to participate in thermogenesis by mediating physiological adaptations required to sustain body…”
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Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat
Published in Proceedings of the National Academy of Sciences - PNAS (04-01-2011)“…Brown fat is specialized for energy expenditure and has therefore been proposed to function as a defense against obesity. Despite recent advances in…”
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FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis
Published in Nature communications (17-03-2020)“…Uncoupling protein-1 (UCP1) plays a central role in energy dissipation in brown adipose tissue (BAT). Using high-throughput library screening of secreted…”
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Endothelin 3/EDNRB signaling induces thermogenic differentiation of white adipose tissue
Published in Nature communications (22-08-2024)“…Thermogenic adipose tissue, consisting of brown and beige fat, regulates nutrient utilization and energy metabolism. Human brown fat is relatively scarce and…”
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Light-responsive adipose-hypothalamus axis controls metabolic regulation
Published in Nature communications (08-08-2024)“…Light is fundamental for biological life, with most mammals possessing light-sensing photoreceptors in various organs. Opsin3 is highly expressed in adipose…”
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New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
Published in Nature (21-08-2008)“…Adipose tissue is central to the regulation of energy balance. Two functionally different types of fat are present in mammals: white adipose tissue, the…”
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Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism
Published in Cell reports (Cambridge) (17-07-2018)“…Thermogenic fat expends energy during cold for temperature homeostasis, and its activity regulates nutrient metabolism and insulin sensitivity. We measured…”
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Increased mitochondrial activity in BMP7-treated brown adipocytes, due to increased CPT1- and CD36-mediated fatty acid uptake
Published in Antioxidants & redox signaling (20-07-2013)“…Brown adipose tissue dissipates chemical energy in the form of heat and regulates triglyceride and glucose metabolism in the body. Factors that regulate fatty…”
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Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation
Published in Nature metabolism (01-06-2022)“…Obesity induces chronic inflammation resulting in insulin resistance and metabolic disorders. Cold exposure can improve insulin sensitivity in humans and…”
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Cross Talk between Insulin and Bone Morphogenetic Protein Signaling Systems in Brown Adipogenesis
Published in Molecular and Cellular Biology (01-09-2010)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Insulin/IGF-I Regulation of Necdin and Brown Adipocyte Differentiation Via CREB- and FoxO1-Associated Pathways
Published in Endocrinology (Philadelphia) (01-10-2011)“…Brown adipose tissue plays an important role in obesity, insulin resistance, and diabetes. We have previously shown that the transition from brown…”
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Cell-autonomous light sensitivity via Opsin3 regulates fuel utilization in brown adipocytes
Published in PLoS biology (10-02-2020)“…Opsin3 (Opn3) is a transmembrane heptahelical G protein-coupled receptor (GPCR) with the potential to produce a nonvisual photoreceptive effect. Interestingly,…”
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Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat
Published in Nature (London) (21-03-2013)“…A shortage of constitutive brown adipose tissue is shown to result when brown adipogenic progenitor cells lack a type of BMP receptor; however, this leads to…”
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The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue
Published in Nature medicine (01-05-2017)“…Cold stimulation induces the synthesis and release of the lipid species 12,13-diHOME from brown adipose tissue. This ‘lipokine’ then acts on brown adipocytes…”
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Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes
Published in Nature medicine (01-07-2015)“…Human brown and white preadipocyte clones from neck fat depots have been isolated and used to identify genetic biomarkers that predict their thermogenic…”
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Fibroblast Growth Factor-9 Regulates Adaptive Brown Adipose Tissue Mass Expansion
Published in Diabetes (New York, N.Y.) (01-07-2018)“…Brown adipose tissue (BAT) plays an essential role in adaptive thermogenesis in response to environmental changes, such as cold and diet. Targeting BAT and…”
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MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1[alpha] signaling network
Published in EMBO reports (01-10-2015)“…Brown adipose tissue (BAT) dissipates chemical energy as heat and can counteract obesity. MicroRNAs are emerging as key regulators in development and disease…”
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MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1α signaling network
Published in EMBO reports (01-10-2015)“…Brown adipose tissue (BAT) dissipates chemical energy as heat and can counteract obesity. MicroRNAs are emerging as key regulators in development and disease…”
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