Search Results - "Huang, Suyun"

Regulation of Metastases by Signal Transducer and Activator of Transcription 3 Signaling Pathway: Clinical Implications by Huang, Suyun

“…Numerous cytokines, growth factors, and oncogenic proteins activate signal transducer and activator of transcription 3 (Stat3), which has been recognized as…”
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EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma by Fang, Runping, Chen, Xin, Zhang, Sicong, Shi, Hui, Ye, Youqiong, Shi, Hailing, Zou, Zhongyu, Li, Peng, Guo, Qing, Ma, Li, He, Chuan, Huang, Suyun

“…Glioblastoma (GBM) is the most common type of adult malignant brain tumor, but its molecular mechanisms are not well understood. In addition, the knowledge of…”
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FoxM1 and Wnt/β-Catenin Signaling in Glioma Stem Cells by Gong, Aihua, Huang, Suyun

“…Cancer stem cells may be responsible for tumor initiation and maintenance. The molecular mechanisms that control cancer stem cells are related to alterations…”
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A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma by Zhang, Maolei, Zhao, Kun, Xu, Xiaoping, Yang, Yibing, Yan, Sheng, Wei, Ping, Liu, Hui, Xu, Jianbo, Xiao, Feizhe, Zhou, Huangkai, Yang, Xuesong, Huang, Nunu, Liu, Jinglei, He, Kejun, Xie, Keping, Zhang, Gong, Huang, Suyun, Zhang, Nu

“…Circular RNAs (circRNAs) are a large class of transcripts in the mammalian genome. Although the translation of circRNAs was reported, additional coding…”
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FOXM1 Promotes the Warburg Effect and Pancreatic Cancer Progression via Transactivation of LDHA Expression by Cui, Jiujie, Shi, Min, Xie, Dacheng, Wei, Daoyan, Jia, Zhiliang, Zheng, Shaojiang, Gao, Yong, Huang, Suyun, Xie, Keping

“…The transcription factor Forkhead box protein M1 (FOXM1) plays critical roles in cancer development and progression. However, the regulatory role and…”
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KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis by Wei, Daoyan, Wang, Liang, Yan, Yongmin, Jia, Zhiliang, Gagea, Mihai, Li, Zhiwei, Zuo, Xiangsheng, Kong, Xiangyu, Huang, Suyun, Xie, Keping

“…Understanding the molecular mechanisms of tumor initiation has significant impact on early cancer detection and intervention. To define the role of KLF4 in…”
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Heterogeneous Blood-Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer by LOCKMAN, Paul R, MITTAPALLI, Rajendar K, SUYUN HUANG, PALMIERI, Diane, STEEG, Patricia S, SMITH, Quentin R, TASKAR, Kunal S, RUDRARAJU, Vinay, GRIL, Brunilde, BOHN, Kaci A, ADKINS, Chris E, ROBERTS, Amanda, THORSHEIM, Helen R, GAASCH, Julie A

“…Brain metastases of breast cancer appear to be increasing in incidence, confer significant morbidity, and threaten to compromise gains made in systemic…”
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FoxM1B transcriptionally regulates vascular endothelial growth factor expression and promotes the angiogenesis and growth of glioma cells by Zhang, Yujian, Zhang, Nu, Dai, Bingbing, Liu, Mingguang, Sawaya, Raymond, Xie, Keping, Huang, Suyun

“…We previously found that FoxM1B is overexpressed in human glioblastomas and that forced FoxM1B expression in anaplastic astrocytoma cells leads to the…”
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Combining Betulinic Acid and Mithramycin A Effectively Suppresses Pancreatic Cancer by Inhibiting Proliferation, Invasion, and Angiogenesis by YONG GAO, ZHILIANG JIA, KEPING XIE, XIANGYU KONG, QIANG LI, CHANG, David Z, DAOYAN WEI, XIANGDONG LE, SHENGDONG HUANG, SUYUN HUANG, LIWEI WANG

“…Both betulinic acid (BA) and mithramycin A (MIT) exhibit potent antitumor activity through distinct mechanisms of Sp1 inhibition. However, it is unknown…”
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The Critical Role of Dysregulated FOXM1―PLAUR Signaling in Human Colon Cancer Progression and Metastasis by Li, Dawei, Wei, Ping, Peng, Zhihai, Huang, Chen, Tang, Huamei, Jia, Zhiliang, Cui, Jiujie, Le, Xiangdong, Huang, Suyun, Xie, Keping

“…The mammalian Forkhead Box (Fox) transcription factor FOXM1 is implicated in tumorigenesis including mouse intestinal cancer. However, the clinical…”
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A Novel FoxM1-Caveolin Signaling Pathway Promotes Pancreatic Cancer Invasion and Metastasis by CHEN HUANG, ZHENGJUN QIU, LIWEI WANG, ZHIHAI PENG, ZHILIANG JIA, LOGSDON, Craig D, XIANGDONG LE, DAOYAN WEI, SUYUN HUANG, KEPING XIE

“…Caveolin-1 (Cav-1), a principal structural component of caveolar membrane domains, contributes to cancer development but its precise functional roles and…”
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Critical Role and Regulation of Transcription Factor FoxM1 in Human Gastric Cancer Angiogenesis and Progression by Li, Qiang, Zhang, Nu, Jia, Zhiliang, Le, Xiangdong, Dai, Bingbing, Wei, Daoyan, Huang, Suyun, Tan, Dongfeng, Xie, Keping

“…The mammalian forkhead box (Fox) transcription factor FoxM1b is implicated in tumorigenesis. However, the presence of expression and role of FoxM1b in gastric…”
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Glioblastoma multiforme formation and EMT: role of FoxM1 transcription factor by Wang, Zhongyong, Zhang, Sicong, Siu, Timothy L, Huang, Suyun

“…Glioblastoma multiforme (GBM) is one of the most malignant cancers in human brain. The prognosis of GBM is extremely poor because it is resistant to…”
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FoxM1 Inhibition Sensitizes Resistant Glioblastoma Cells to Temozolomide by Downregulating the Expression of DNA-Repair Gene Rad51 by Zhang, Nu, Wu, Xinjian, Yang, Lixuan, Xiao, Feizhe, Zhang, Heng, Zhou, Aidong, Huang, Zhengsong, Huang, Suyun

“…Recurrent glioblastoma multiforme (GBM) is characterized by resistance to radiotherapy and chemotherapy and a poor clinical prognosis. In this study, we…”
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tRNA Function and Dysregulation in Cancer by Gupta, Tania, Malkin, Mark G., Huang, Suyun

“…Transfer RNA (tRNA) is a central component of protein synthesis and plays important roles in epigenetic regulation of gene expression in tumors. tRNAs are also…”
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Dysregulated Expression of FOXM1 Isoforms Drives Progression of Pancreatic Cancer by Kong, Xiangyu, Li, Lei, Li, Zhaoshen, Le, Xiangdong, Huang, Chen, Jia, Zhiliang, Cui, Jiujie, Huang, Suyun, Wang, Liwei, Xie, Keping

“…The transcription factor Forkhead box M1 (FOXM1) plays important roles in oncogenesis. However, the expression statuses of FOXM1 isoforms and their impact on…”
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Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis by XIE, Tong-Xin, DAOYAN WEI, MINGGUANG LIU, GAO, Allen C, ALI-OSMAN, Francis, SAWAYA, Raymond, SUYUN HUANG

“…The expression of matrix metalloproteinase-2 (MMP-2) has been linked with tumor invasion, angiogenesis, and metastasis. However, the molecular basis for MMP-2…”
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Src Family Kinases as Novel Therapeutic Targets to Treat Breast Cancer Brain Metastases by SIYUAN ZHANG, HUANG, Wen-Chien, ALDAPE, Kenneth D, STEEG, Patricia S, DIHUA YU, LIN ZHANG, CHENYU ZHANG, LOWERY, Frank J, ZHAOXI DING, HUA GUO, HAI WANG, SUYUN HUANG, SAHIN, Aysegul A

“…Despite better control of early-stage disease and improved overall survival of patients with breast cancer, the incidence of life-threatening brain metastases…”
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Emerging role of KLF4 in human gastrointestinal cancer by Wei, Daoyan, Kanai, Masashi, Huang, Suyun, Xie, Keping

“…Recent analyses revealed that Krüppel-like factors (KLFs) play important roles in both normal development and carcinogenesis. Of the 16 known KLFs, KLF4 has…”
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Forkhead Box M1 Is Essential for Nuclear Localization of Glioma-associated Oncogene Homolog 1 in Glioblastoma Multiforme Cells by Promoting Importin-7 Expression by Xue, Jianfei, Zhou, Aidong, Tan, Christina, Wu, Yamei, Lee, Hsueh-Te, Li, Wenliang, Xie, Keping, Huang, Suyun

“…The transcription factors glioma-associated oncogene homolog 1 (GLI1), a primary marker of Hedgehog pathway activation, and Forkhead box M1 (FOXM1) are…”
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