Search Results - "Huang, Shuya Kate"

Delineating the conformational landscape of the adenosine A2A receptor during G protein coupling by Huang, Shuya Kate, Pandey, Aditya, Tran, Duy Phuoc, Villanueva, Nicolas L., Kitao, Akio, Sunahara, Roger K., Sljoka, Adnan, Prosser, R. Scott

“…G-protein-coupled receptors (GPCRs) represent a ubiquitous membrane protein family and are important drug targets. Their diverse signaling pathways are driven…”
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Correlating histone acetylation with nucleosome core particle dynamics and function by Kim, Tae Hun, Nosella, Michael L, Bolik-Coulon, Nicolas, Harkness, Robert W, Huang, Shuya Kate, Kay, Lewis E

“…Epigenetic modifications of chromatin play a critical role in regulating the fidelity of the genetic code and in controlling the translation of genetic…”
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Allosteric modulation of the adenosine A2A receptor by cholesterol by Huang, Shuya Kate, Almurad, Omar, Pejana, Reizel J, Morrison, Zachary A, Pandey, Aditya, Picard, Louis-Philippe, Nitz, Mark, Sljoka, Adnan, Prosser, R Scott

“…Cholesterol is a major component of the cell membrane and commonly regulates membrane protein function. Here, we investigate how cholesterol modulates the…”
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Dynamics and mechanistic underpinnings to pharmacology of class A GPCRs: an NMR perspective by Huang, Shuya Kate, Prosser, R Scott

“…One-third of current pharmaceuticals target G protein-coupled receptors (GPCRs), the largest receptor superfamily in humans and mediators of diverse…”
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Cryo-EM of the Nucleosome Core Particle Bound to Ran-RCC1 Reveals a Dynamic Complex by Huang, Shuya Kate, Rubinstein, John L., Kay, Lewis E.

“…Ras-related nuclear protein (Ran) is a member of the Ras superfamily of small guanosine triphosphatases (GTPases) and a regulator of multiple cellular…”
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Atomic resolution map of the solvent interactions driving SOD1 unfolding in CAPRIN1 condensates by Ahmed, Rashik, Liang, Mingyang, Hudson, Rhea P, Rangadurai, Atul K, Huang, Shuya Kate, Forman-Kay, Julie D, Kay, Lewis E

“…Biomolecules can be sequestered into membrane-less compartments, referred to as biomolecular condensates. Experimental and computational methods have helped…”
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A2AR expression, purification, and nanodisc reconstitution by Huang, Shuya Kate, Prosser, R Scott

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Balancing G protein selectivity and efficacy in the adenosine A2A receptor by Picard, Louis-Philippe, Orazietti, Alexander, Tran, Duy Phuoc, Tucs, Andrejs, Hagimoto, Sari, Qi, Zhenzhou, Huang, Shuya Kate, Tsuda, Koji, Kitao, Akio, Sljoka, Adnan, Prosser, R. Scott

“…The adenosine A2A receptor (A2AR) engages several G proteins, notably Go and its cognate Gs protein. This coupling promiscuity is facilitated by a dynamic…”
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Author Correction: Balancing G protein selectivity and efficacy in the adenosine A2A receptor by Picard, Louis-Philippe, Orazietti, Alexander, Tran, Duy Phuoc, Tucs, Andrejs, Hagimoto, Sari, Qi, Zhenzhou, Huang, Shuya Kate, Tsuda, Koji, Kitao, Akio, Sljoka, Adnan, Prosser, R. Scott

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Mapping the conformational landscape of the stimulatory heterotrimeric G protein by Huang, Shuya Kate, Picard, Louis-Philippe, Rahmatullah, Rima S. M., Pandey, Aditya, Van Eps, Ned, Sunahara, Roger K., Ernst, Oliver P., Sljoka, Adnan, Prosser, R. Scott

“…Heterotrimeric G proteins serve as membrane-associated signaling hubs, in concert with their cognate G-protein-coupled receptors. Fluorine nuclear magnetic…”
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Delineating the Conformational Landscape of the Adenosine A2A Receptor-G Protein Signaling Complex by Huang, Shuya Kate

“…G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors in eukaryotes. Their canonical activation involves binding by an…”
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Allosteric modulation of the adenosine A.sub.2A receptor by cholesterol by Huang, Shuya Kate, Almurad, Omar, Pejana, Reizel J, Morrison, Zachary A, Pandey, Aditya, Picard, Louis-Philippe, Nitz, Mark, Sljoka, Adnan, Prosser, R Scott

“…Cholesterol is a major component of the cell membrane and commonly regulates membrane protein function. Here, we investigate how cholesterol modulates the…”
Get full text

Author Correction: Balancing G protein selectivity and efficacy in the adenosine A 2A receptor by Picard, Louis-Philippe, Orazietti, Alexander, Tran, Duy Phuoc, Tucs, Andrejs, Hagimoto, Sari, Qi, Zhenzhou, Huang, Shuya Kate, Tsuda, Koji, Kitao, Akio, Sljoka, Adnan, Prosser, R Scott

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Balancing G protein selectivity and efficacy in the adenosine A 2A receptor by Picard, Louis-Philippe, Orazietti, Alexander, Tran, Duy Phuoc, Tucs, Andrejs, Hagimoto, Sari, Qi, Zhenzhou, Huang, Shuya Kate, Tsuda, Koji, Kitao, Akio, Sljoka, Adnan, Prosser, R Scott

“…The adenosine A receptor (A R) engages several G proteins, notably G and its cognate G protein. This coupling promiscuity is facilitated by a dynamic ensemble,…”
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Allosteric modulation of the adenosine A 2A receptor by cholesterol by Huang, Shuya Kate, Almurad, Omar, Pejana, Reizel J, Morrison, Zachary A, Pandey, Aditya, Picard, Louis-Philippe, Nitz, Mark, Sljoka, Adnan, Prosser, R Scott

“…Cholesterol is a major component of the cell membrane and commonly regulates membrane protein function. Here, we investigate how cholesterol modulates the…”
Get full text

Delineating the conformational landscape of the adenosine A 2A receptor during G protein coupling by Huang, Shuya Kate, Pandey, Aditya, Tran, Duy Phuoc, Villanueva, Nicolas L, Kitao, Akio, Sunahara, Roger K, Sljoka, Adnan, Prosser, R Scott

“…G-protein-coupled receptors (GPCRs) represent a ubiquitous membrane protein family and are important drug targets. Their diverse signaling pathways are driven…”
Get full text