Search Results - "Huang, Shile"

mTOR Signaling in Metabolism and Cancer by Huang, Shile

“…The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a central regulator for human physiological activity. Deregulated mTOR…”
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Ganoderma lucidum Polysaccharides as An Anti-cancer Agent by Sohretoglu, Didem, Huang, Shile

“…The mushroom Ganoderma lucidum (G. lucidum) has been used for centuries in Asian countries to treat various diseases and to promote health and longevity…”
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The role of Cdc25A in the regulation of cell proliferation and apoptosis by Shen, Tao, Huang, Shile

“…Cell division cycle 25 A (Cdc25A), a dual-specificity protein phosphatase, is one of the most crucial cell cycle regulators, which removes the inhibitory…”
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Role of mTOR signaling in tumor cell motility, invasion and metastasis by Zhou, Hongyu, Huang, Shile

“…Tumor cell migration and invasion play fundamental roles in cancer metastasis. The mammalian target of rapamycin (mTOR), a highly conserved and ubiquitously…”
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The targets of curcumin by Zhou, Hongyu, Beevers, Christopher S, Huang, Shile

“…Curcumin (diferuloylmethane), an orange-yellow component of turmeric or curry powder, is a polyphenol natural product isolated from the rhizome of the plant…”
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Host Immune Response to Influenza A Virus Infection by Chen, Xiaoyong, Liu, Shasha, Goraya, Mohsan Ullah, Maarouf, Mohamed, Huang, Shile, Chen, Ji-Long

“…Influenza A viruses (IAVs) are contagious pathogens responsible for severe respiratory infection in humans and animals worldwide. Upon detection of IAV…”
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Repositioning the Old Fungicide Ciclopirox for New Medical Uses by Shen, Tao, Huang, Shile

“…Ciclopirox (CPX) has been used as an antifungal agent in various formulations to treat superficial fungal infection for decades. Its effectiveness and safety…”
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Reposition of the Fungicide Ciclopirox for Cancer Treatment by Huang, Zhu, Huang, Shile

“…Ciclopirox (CPX), a broad-spectrum fungicide, has been widely used to treat fungal infection on the skin and nails for decades. Recent preclinical and clinical…”
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Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5 by Chen, Long, Liu, Lei, Huang, Shile

“…Cadmium (Cd), a highly toxic environmental pollutant, induces neurodegenerative diseases. Recently we have demonstrated that Cd may induce neuronal apoptosis…”
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Iron chelation inhibits mTORC1 signaling involving activation of AMPK and REDD1/Bnip3 pathways by Shang, Chaowei, Zhou, Hongyu, Liu, Wang, Shen, Tao, Luo, Yan, Huang, Shile

“…The mammalian target of rapamycin (mTOR) functions as two complexes (mTORC1 and mTORC2), regulating cell growth and metabolism. Aberrant mTOR signaling occurs…”
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The complexes of mammalian target of rapamycin by Zhou, Hongyu, Huang, Shile

“…The mammalian target of rapamycin (mTOR) has attracted substantial attention because of its involvement in a variety of diseases, such as cancer, cardiac…”
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Molecular evidence of cryptotanshinone for treatment and prevention of human cancer by Chen, Wenxing, Lu, Yin, Chen, Guangying, Huang, Shile

“…Cryptotanshinone is one of the major tanshinones isolated from the roots of the plant Salvia miltiorrhiza Bunge (Danshen). Danshen has been widely used in…”
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Knocking out alpha-synuclein in melanoma cells dysregulates cellular iron metabolism and suppresses tumor growth by Shekoohi, Sahar, Rajasekaran, Santhanasabapathy, Patel, Dhaval, Yang, Shu, Liu, Wang, Huang, Shile, Yu, Xiuping, Witt, Stephan N.

“…The protein alpha-synuclein (α-syn) is unusual because, depending on its conformation and the type of cell in which it is expressed, it is pro-death or…”
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Updates of mTOR inhibitors by Zhou, Hongyu, Luo, Yan, Huang, Shile

“…Mammalian target of rapamycin (mTOR) is a central controller of cell growth, proliferation, metabolism and angiogenesis. mTOR signaling is often dysregulated…”
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The bromodomain protein BRD4 positively regulates necroptosis via modulating MLKL expression by Xiong, Yu, Li, Linli, Zhang, Liting, Cui, Yangyang, Wu, Chengyong, Li, Hui, Chen, Kai, Yang, Qiuyuan, Xiang, Rong, Hu, Yiguo, Huang, Shile, Wei, Yuquan, Yang, Shengyong

“…Necroptosis is a programmed form of necrotic cell death, which is tightly regulated by the necroptotic signaling pathway containing receptor-interacting…”
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Newly synthesized Mpro inhibitors as potential oral anti-SARS-CoV-2 agents by Li, Lin, Huang, Shile

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A new clue to explain resistance to mTOR inhibitors by Huang, Shile

“…Comment on: Zhang Y, et al. Cell Cycle 2012; 11:594-603…”
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MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis by Chen, Long, Liu, Lei, Luo, Yan, Huang, Shile

“…Cadmium (Cd) may be accumulated in human body through long-term exposure to Cd-polluted environment, resulting in neurodegeneration and other diseases. To…”
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Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease by Xu, Yijiao, Liu, Chunxiao, Chen, Sujuan, Ye, Yangjing, Guo, Min, Ren, Qian, Liu, Lei, Zhang, Hai, Xu, Chong, Zhou, Qian, Huang, Shile, Chen, Long

“…Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of dopaminergic neurons. Dysregulation of mammalian target of rapamycin (mTOR)…”
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Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death by Chen, Long, Xu, Baoshan, Liu, Lei, Luo, Yan, Zhou, Hongyu, Chen, Wenxing, Shen, Tao, Han, Xiuzhen, Kontos, Christopher D., Huang, Shile

“…Cadmium (Cd), a highly toxic environmental pollutant, induces neurodegenerative diseases. Recently we have demonstrated that Cd induces neuronal apoptosis in…”
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