Search Results - "Huang, S.‐C."

De-escalating and escalating treatments for early-stage breast cancer: the St. Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017 by Curigliano, G, Burstein, H.J., Winer, E.P., Gnant, M., Dubsky, P., Loibl, S., Colleoni, M., Regan, M.M., Piccart-Gebhart, M., Senn, H.-J., Thürlimann, B., André, F., Baselga, J., Bergh, J., Bonnefoi, H., Brucker, S.Y., Cardoso, F., Carey, L., Ciruelos, E., Cuzick, J., Denkert, C., Di Leo, A., Ejlertsen, B., Francis, P., Galimberti, V., Garber, J., Gulluoglu, B., Goodwin, P., Harbeck, N., Hayes, D.F., Huang, C.-S., Huober, J., Khaled, H., Jassem, J., Jiang, Z., Karlsson, P., Morrow, M., Orecchia, R., Osborne, K.C., Pagani, O., Partridge, A.H., Pritchard, K., Ro, J., Rutgers, E.J.T., Sedlmayer, F., Semiglazov, V., Shao, Z., Smith, I., Toi, M., Tutt, A., Viale, G., Watanabe, T., Whelan, T.J., Xu, B.

“…The 15th St. Gallen International Breast Cancer Conference 2017 in Vienna, Austria reviewed substantial new evidence on loco-regional and systemic therapies…”
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PET of Brain Amyloid and Tau in Mild Cognitive Impairment by Small, Gary W, Kepe, Vladimir, Ercoli, Linda M, Siddarth, Prabha, Bookheimer, Susan Y, Miller, Karen J, Lavretsky, Helen, Burggren, Alison C, Cole, Greg M, Vinters, Harry V, Thompson, Paul M, Huang, S.-C, Satyamurthy, N, Phelps, Michael E, Barrio, Jorge R

“…A small molecule (FDDNP) that binds amyloid senile plaques and tau neurofibrillary tangles (the neuropathological findings in Alzheimer's disease) was injected…”
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Adjuvant T-DM1 versus trastuzumab in patients with residual invasive disease after neoadjuvant therapy for HER2-positive breast cancer: subgroup analyses from KATHERINE by Mamounas, E.P., Untch, M., Mano, M.S., Huang, C.-S., Geyer Jr, C.E., von Minckwitz, G., Wolmark, N., Pivot, X., Kuemmel, S., DiGiovanna, M.P., Kaufman, B., Kunz, G., Conlin, A.K., Alcedo, J.C., Kuehn, T., Wapnir, I., Fontana, A., Hackmann, J., Polikoff, J., Saghatchian, M., Brufsky, A., Yang, Y., Zimovjanova, M., Boulet, T., Liu, H., Tesarowski, D., Lam, L.H., Song, C., Smitt, M., Loibl, S.

“…In the KATHERINE study (NCT01772472), patients with residual invasive early breast cancer (EBC) after neoadjuvant chemotherapy (NACT) plus human epidermal…”
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Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics by Cragg, Mark S, Kuroda, Junya, Puthalakath, Hamsa, Huang, David C S, Strasser, Andreas

“…The epidermal growth factor receptor (EGFR) plays a critical role in the control of cellular proliferation, differentiation, and survival. Abnormalities in…”
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PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling by Yao, Bing, Gui, Tao, Zeng, Xiangwei, Deng, Yexuan, Wang, Zhi, Wang, Ying, Yang, Dongjun, Li, Qixiang, Xu, Peipei, Hu, Ruifeng, Li, Xinyu, Chen, Bing, Wang, Jin, Zen, Ke, Li, Haitao, Davis, Melissa J, Herold, Marco J, Pan, Hua-Feng, Jiang, Zhi-Wei, Huang, David C S, Liu, Ming, Ju, Junyi, Zhao, Quan

“…Aberrant changes in epigenetic mechanisms such as histone modifications play an important role in cancer progression. PRMT1 which triggers asymmetric…”
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Role of the p38 pathway in mineral trioxide aggregate-induced cell viability and angiogenesis-related proteins of dental pulp cell in vitro by Huang, S.-C., Wu, B.-C., Kao, C.-T., Huang, T.-H., Hung, C.-J., Shie, M.-Y.

“…Aim To investigate the influence of mineral trioxide aggregate (MTA) on angiogenesis of primary human dental pulp cells (hDPCs) via the MAPK pathway, in…”
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Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease by ROBERTS, Andrew W, SEYMOUR, John F, YUE CUI, BUSMAN, Todd A, MCKEEGAN, Evelyn M, KRIVOSHIK, Andrew P, ENSCHEDE, Sari H, HUMERICKHOUSE, Rod, BROWN, Jennifer R, WIERDA, William G, KIPPS, Thomas J, SEONG LIN KHAW, CARNEY, Dennis A, HE, Simon Z, HUANG, David C. S, HAO XIONG

“…BCL2 overexpression is a hallmark of chronic lymphocytic leukemia (CLL). The novel BH3 mimetic navitoclax (ABT-263) specifically inhibits BCL2 and related…”
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Patterns of recurrence after oesophagectomy and postoperative chemoradiotherapy versus surgery alone for oesophageal squamous cell carcinoma by Hsu, P.‐K., Chen, H.‐S., Huang, C.‐S., Liu, C.‐C., Hsieh, C.‐C., Hsu, H.‐S., Wu, Y.‐C., Wu, S.‐C.

“…Background Patterns of recurrence after surgery with postoperative chemoradiotherapy (S‐CCRT) or surgery alone in patients with oesophageal squamous cell…”
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BCL2 and MCL1 inhibitors for hematologic malignancies by Roberts, Andrew W., Wei, Andrew H., Huang, David C.S.

“…BCL2 and MCL1 are commonly expressed prosurvival (antiapoptotic) proteins in hematologic cancers and play important roles in their biology either through…”
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Sensitization of BCL-2–expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737 by Oakes, Samantha R, Vaillant, François, Lim, Elgene, Lee, Lily, Breslin, Kelsey, Feleppa, Frank, Deb, Siddhartha, Ritchie, Matthew E, Takano, Elena, Ward, Teresa, Fox, Stephen B, Generali, Daniele, Smyth, Gordon K, Strasser, Andreas, Huang, David C. S, Visvader, Jane E, Lindeman, Geoffrey J

“…Overexpression of the prosurvival protein BCL-2 is common in breast cancer. Here we have explored its role as a potential therapeutic target in this disease…”
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Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection by Masamsetti, V. Pragathi, Low, Ronnie Ren Jie, Mak, Ka Sin, O’Connor, Aisling, Riffkin, Chris D., Lamm, Noa, Crabbe, Laure, Karlseder, Jan, Huang, David C. S., Hayashi, Makoto T., Cesare, Anthony J.

“…Mitotic catastrophe is a broad descriptor encompassing unclear mechanisms of cell death. Here we investigate replication stress-driven mitotic catastrophe in…”
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Final results of the double-blind placebo-controlled randomized phase 2 LOTUS trial of first-line ipatasertib plus paclitaxel for inoperable locally advanced/metastatic triple-negative breast cancer by Dent, Rebecca, Oliveira, Mafalda, Isakoff, Steven J., Im, Seock-Ah, Espié, Marc, Blau, Sibel, Tan, Antoinette R., Saura, Cristina, Wongchenko, Matthew J., Xu, Na, Bradley, Denise, Reilly, Sarah-Jayne, Mani, Aruna, Kim, Sung-Bae

“…Purpose In LOTUS (NCT02162719), adding the oral AKT inhibitor ipatasertib to first-line paclitaxel for locally advanced/metastatic triple-negative breast…”
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XIAP discriminates between type I and type II FAS-induced apoptosis by Strasser, Andreas, Kaufmann, Thomas, Jost, Philipp J, Grabow, Stephanie, Gray, Daniel, McKenzie, Mark D, Nachbur, Ueli, Huang, David C. S, Bouillet, Philippe, Thomas, Helen E, Borner, Christoph, Silke, John

“…FAS (also called APO-1 and CD95) and its physiological ligand, FASL, regulate apoptosis of unwanted or dangerous cells, functioning as a guardian against…”
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Key residues in the VDAC2-BAK complex can be targeted to modulate apoptosis by Yuan, Zheng, van Delft, Mark F, Li, Mark Xiang, Sumardy, Fransisca, Smith, Brian J, Huang, David C S, Lessene, Guillaume, Khakam, Yelena, Jin, Ruitao, He, Sitong, Smith, Nicholas A, Birkinshaw, Richard W, Czabotar, Peter E, Dewson, Grant

“…BAK and BAX execute intrinsic apoptosis by permeabilising the mitochondrial outer membrane. Their activity is regulated through interactions with pro-survival…”
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Plaque and tangle imaging and cognition in normal aging and Alzheimer's disease by Braskie, Meredith N, Klunder, Andrea D, Hayashi, Kiralee M, Protas, Hillary, Kepe, Vladimir, Miller, Karen J, Huang, S.-C, Barrio, Jorge R, Ercoli, Linda M, Siddarth, Prabha, Satyamurthy, Nagichettiar, Liu, Jie, Toga, Arthur W, Bookheimer, Susan Y, Small, Gary W, Thompson, Paul M

“…Abstract Amyloid plaques and tau neurofibrillary tangles, the pathological hallmarks of Alzheimer's disease (AD), begin accumulating in the healthy human brain…”
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Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function by Schoenwaelder, Simone M., Yuan, Yuping, Josefsson, Emma C., White, Michael J., Yao, Yu, Mason, Kylie D., O'Reilly, Lorraine A., Henley, Katya J., Ono, Akiko, Hsiao, Sarah, Willcox, Abbey, Roberts, Andrew W., Huang, David C.S., Salem, Hatem H., Kile, Benjamin T., Jackson, Shaun P.

“…Procoagulant platelets exhibit hallmark features of apoptotic cells, including membrane blebbing, microvesiculation, and phosphatidylserine (PS) exposure…”
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Vitamin B6 supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis by Huang, S.C, Wei, J.C.C, Wu, D.J, Huang, Y.C

“…Background/Objectives: The purpose of this study was to investigate whether vitamin B6 supplementation had a beneficial effect on inflammatory and immune…”
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DNA-PK/Chk2 induces centrosome amplification during prolonged replication stress by Wang, C-Y, Huang, E Y-H, Huang, S-c, Chung, B-c

“…The antineoplastic drug hydroxyurea (HU), when used at subtoxic doses, induces prolonged replication stress and centrosome amplification. This causes genomic…”
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Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak by Willis, Simon N, Fletcher, Jamie I, Kaufmann, Thomas, van Delft, Mark F, Chen, Lin, Czabotar, Peter E, Ierino, Helen, Lee, Erinna F, Fairlie, W. Douglas, Bouillet, Philippe, Strasser, Andreas, Kluck, Ruth M, Adams, Jerry M, Huang, David C.S

“…A central issue in the regulation of apoptosis by the Bcl-2 family is whether its BH3-only members initiate apoptosis by directly binding to the essential…”
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Vibration analysis of rectangular plates with side cracks via the Ritz method by Huang, C.S., Leissa, A.W.

“…This analysis deals with free vibrations of a rectangular plate with a side crack by using the famous Ritz method with special displacement functions. To…”
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