Search Results - "Huang, R Stephanie"

pRRophetic: an R package for prediction of clinical chemotherapeutic response from tumor gene expression levels by Geeleher, Paul, Cox, Nancy, Huang, R Stephanie

“…We recently described a methodology that reliably predicted chemotherapeutic response in multiple independent clinical trials. The method worked by building…”
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Computationally predicting clinical drug combination efficacy with cancer cell line screens and independent drug action by Ling, Alexander, Huang, R. Stephanie

“…Evidence has recently emerged that many clinical cancer drug combinations may derive their efficacy from independent drug action (IDA), where patients only…”
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Identification of MicroRNAs as Breast Cancer Prognosis Markers through the Cancer Genome Atlas by Chang, Jeremy T-H, Wang, Fan, Chapin, William, Huang, R Stephanie

“…Breast cancer is the second-most common cancer and second-leading cause of cancer mortality in American women. The dysregulation of microRNAs (miRNAs) plays a…”
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Cancer expression quantitative trait loci (eQTLs) can be determined from heterogeneous tumor gene expression data by modeling variation in tumor purity by Geeleher, Paul, Nath, Aritro, Wang, Fan, Zhang, Zhenyu, Barbeira, Alvaro N, Fessler, Jessica, Grossman, Robert L, Seoighe, Cathal, Stephanie Huang, R

“…Expression quantitative trait loci (eQTLs) identified using tumor gene expression data could affect gene expression in cancer cells, tumor-associated normal…”
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Deciphering genetic causes for sex differences in human health through drug metabolism and transporter genes by Huang, Yingbo, Shan, Yuting, Zhang, Weijie, Lee, Adam M., Li, Feng, Stranger, Barbara E., Huang, R. Stephanie

“…Sex differences have been widely observed in human health. However, little is known about the underlying mechanism behind these observed sex differences. We…”
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The Promise of Pharmacogenomics in Reducing Toxicity During Acute Lymphoblastic Leukemia Maintenance Treatment by Rudin, Shoshana, Marable, Marcus, Huang, R. Stephanie

“…Pediatric acute lymphoblastic leukemia (ALL) affects a substantial number of children every year and requires a long and rigorous course of chemotherapy…”
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Pharmacogenetics and Pharmacogenomics of Targeted Therapeutics in Chronic Myeloid Leukemia by Nath, Aritro, Wang, Jacqueline, Stephanie Huang, R.

“…The advent of targeted therapeutics has greatly improved outcomes of chronic myeloid leukemia (CML) patients. Despite increased efficacy and better clinical…”
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A systematic review on sex differences in adverse drug reactions related to psychotropic, cardiovascular, and analgesic medications by Shan, Yuting, Cheung, Lee, Zhou, Yuqi, Huang, Yingbo, Huang, R Stephanie

“…Adverse drug reactions (ADRs) are the main safety concerns of clinically used medications. Accumulating evidence has shown that ADRs can affect men and women…”
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Long Non-Coding RNA ANRIL as a Potential Biomarker of Chemosensitivity and Clinical Outcomes in Osteosarcoma by Lee, Adam M, Ferdjallah, Asmaa, Moore, Elise, Kim, Daniel C, Nath, Aritro, Greengard, Emily, Huang, R Stephanie

“…Osteosarcoma has a poor prognosis due to chemo-resistance and/or metastases. Increasing evidence shows that long non-coding RNAs (lncRNAs) can play an…”
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The impact of the Cancer Genome Atlas on lung cancer by Chang, Jeremy T.-H, Lee, Yee Ming, Huang, R. Stephanie

“…The Cancer Genome Atlas (TCGA) has profiled more than 10,000 samples derived from 33 types of cancer to date, with the goal of improving our understanding of…”
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Pharmacogenomics of Cisplatin Sensitivity in Non-small Cell Lung Cancer by Rose, Maimon C., Kostyanovskaya, Elina, Huang, R. Stephanie

“…Cisplatin, a platinum-based chemotherapeutic drug, has been used for over 30years in a wide variety of cancers with varying degrees of success. In particular,…”
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Genetic Architecture of MicroRNA Expression: Implications for the Transcriptome and Complex Traits by Gamazon, Eric R., Ziliak, Dana, Im, Hae Kyung, LaCroix, Bonnie, Park, Danny S., Cox, Nancy J., Huang, R. Stephanie

“…We sought to comprehensively and systematically characterize the relationship between genetic variation, miRNA expression, and mRNA expression. Genome-wide…”
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High Expression of miR-532-5p, a Tumor Suppressor, Leads to Better Prognosis in Ovarian Cancer Both In Vivo and In Vitro by Wang, Fan, Chang, Jeremy T-H, Kao, Chester Jingshiu, Huang, R Stephanie

“…Ovarian cancer is the leading cause of death for gynecologic cancers, ranking fifth overall for cancer-related death among women. The identification of…”
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Pharmacogenetics and pharmacogenomics: a bridge to individualized cancer therapy by Weng, Liming, Zhang, Li, Peng, Yan, Huang, R Stephanie

“…In the past decade, advances in pharmacogenetics and pharmacogenomics (PGx) have gradually unveiled the genetic basis of interindividual differences in drug…”
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Computational drug discovery pipelines identify NAMPT as a therapeutic target in neuroendocrine prostate cancer by Zhang, Weijie, Lee, Adam, Lee, Lauren, Dehm, Scott M., Huang, R. Stephanie

“…Neuroendocrine prostate cancer (NEPC) is an aggressive advanced subtype of prostate cancer that exhibits poor prognosis and broad resistance to therapies…”
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Chemotherapeutic drug susceptibility associated SNPs are enriched in expression quantitative trait loci by Gamazon, Eric R, Huang, R. Stephanie, Cox, Nancy J, Dolan, M. Eileen

“…Pharmacogenomics has employed candidate gene studies and, more recently, genome-wide association studies (GWAS) in efforts to identify loci associated with…”
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Variants at 6q21 implicate PRDM1 in the etiology of therapy-induced second malignancies after Hodgkin's lymphoma by Best, Timothy, Li, Dalin, Skol, Andrew D, Kirchhoff, Tomas, Jackson, Sarah A, Yasui, Yutaka, Bhatia, Smita, Strong, Louise C, Domchek, Susan M, Nathanson, Katherine L, Olopade, Olufunmilayo I, Huang, R Stephanie, Mack, Thomas M, Conti, David V, Offit, Kenneth, Cozen, Wendy, Robison, Leslie L, Onel, Kenan

“…Patients undergoing radiation treatment for Hodgkins's lymphoma are at increased risk of developing secondary malignancies with time. This genome-wide analysis…”
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Pharmacogenomics of EGFR-targeted therapies in non-small cell lung cancer： EGFR and beyond by Delaney, Christopher, Frank, Samuel, Huang, R Stephanie

“…Commonly observed aberrations in epidermal growth factor receptor （EGFR） signaling have led to the development of EGFR-targeted therapies for various cancers,…”
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Computational Modeling to Identify Drugs Targeting Metastatic Castration-Resistant Prostate Cancer Characterized by Heightened Glycolysis by Su, Mei-Chi, Lee, Adam M, Zhang, Weijie, Maeser, Danielle, Gruener, Robert F, Deng, Yibin, Huang, R Stephanie

“…Metastatic castration-resistant prostate cancer (mCRPC) remains a deadly disease due to a lack of efficacious treatments. The reprogramming of cancer…”
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Identification of Genetic Variants Contributing to Cisplatin-Induced Cytotoxicity by Use of a Genomewide Approach by Huang, R. Stephanie, Duan, Shiwei, Shukla, Sunita J., Kistner, Emily O., Clark, Tyson A., Chen, Tina X., Schweitzer, Anthony C., Blume, John E., Dolan, M. Eileen

“…Cisplatin, a platinating agent commonly used to treat several cancers, is associated with nephrotoxicity, neurotoxicity, and ototoxicity, which has hindered…”
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