Search Results - "Huang, Mingtao"
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Exploring the potential of Saccharomyces cerevisiae for biopharmaceutical protein production
Published in Current opinion in biotechnology (01-12-2017)“…Graphical abstract…”
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Global rewiring of cellular metabolism renders Saccharomyces cerevisiae Crabtree negative
Published in Nature communications (03-08-2018)“…Saccharomyces cerevisiae is a Crabtree-positive eukaryal model organism. It is believed that the Crabtree effect has evolved as a competition mechanism by…”
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Moral courage of master’s students of nursing during COVID-19
Published in Nursing ethics (01-06-2023)“…Background Moral courage is a recognized virtue. In the context of the COVID-19 pandemic, the master’s students of nursing (MSNs) in China have shown tenacious…”
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High-throughput screening for industrial enzyme production hosts by droplet microfluidics
Published in Lab on a chip (01-01-2014)“…A high-throughput method for single cell screening by microfluidic droplet sorting is applied to a whole-genome mutated yeast cell library yielding improved…”
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Efficient protein production by yeast requires global tuning of metabolism
Published in Nature communications (25-10-2017)“…The biotech industry relies on cell factories for production of pharmaceutical proteins, of which several are among the top-selling medicines. There is,…”
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Curcumin protects against fenvalerate-induced neurotoxicity in zebrafish (Danio rerio) larvae through inhibition of oxidative stress
Published in Ecotoxicology and environmental safety (01-10-2023)“…Fenvalerate (FEN), a typical type II pyrethroid pesticide, is widely used in agriculture. FEN has been detected in the environment and human body. However, the…”
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Myclobutanil induces cardiotoxicity in developing zebrafish larvae by initiating oxidative stress and apoptosis: The protective role of curcumin
Published in Ecotoxicology and environmental safety (01-07-2024)“…Myclobutanil (MYC) is a common triazole fungicide widely applied in agriculture. MYC extensively exists in the natural environment and can be detected in…”
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Yeast metabolism adaptation for efficient terpenoids synthesis via isopentenol utilization
Published in Nature communications (13-11-2024)“…Microbial biosynthesis has become the leading commercial approach for large-scale production of terpenoids, a valuable class of natural products. Enhancing…”
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Microfluidic screening and whole-genome sequencing identifies mutations associated with improved protein secretion by yeast
Published in Proceedings of the National Academy of Sciences - PNAS (25-08-2015)“…There is an increasing demand for biotech-based production of recombinant proteins for use as pharmaceuticals in the food and feed industry and in industrial…”
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Improving recombinant protein production by yeast through genome-scale modeling using proteome constraints
Published in Nature communications (27-05-2022)“…Eukaryotic cells are used as cell factories to produce and secrete multitudes of recombinant pharmaceutical proteins, including several of the current…”
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Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations
Published in The lancet respiratory medicine (01-10-2019)“…Genetic variation has an important role in the development of non-small-cell lung cancer (NSCLC). However, genetic factors for lung cancer have not been fully…”
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Modular pathway rewiring of Saccharomyces cerevisiae enables high-level production of L-ornithine
Published in Nature communications (08-09-2015)“…Baker’s yeast Saccharomyces cerevisiae is an attractive cell factory for production of chemicals and biofuels. Many different products have been produced in…”
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Factors associated with the moral courage of nurses in China: A cross‐sectional study
Published in Nursing open (01-07-2023)“…Aim The purpose of this study was to assess the level of moral courage among nurses in China, and to explore related influential factors, to help nursing…”
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A PCR-independent approach for mtDNA enrichment and next-generation sequencing: comprehensive evaluation and clinical application
Published in Journal of translational medicine (25-04-2024)“…Sequencing the mitochondrial genome has been increasingly important for the investigation of primary mitochondrial diseases (PMD) and mitochondrial genetics…”
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Advances in the dynamic control of metabolic pathways in Saccharomyces cerevisiae
Published in Engineering Microbiology (01-12-2023)“…The metabolic engineering of Saccharomyces cerevisiae has great potential for enhancing the production of high-value chemicals and recombinant proteins. Recent…”
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Reproductive outcomes in couples with sporadic miscarriage after embryonic chromosomal microarray analysis
Published in Annals of medicine (Helsinki) (01-12-2023)“…Chromosomal microarray analysis (CMA) has been widely applied to genetic diagnosis in miscarriages in clinical practice. However, the prognostic value of CMA…”
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Comprehensive genetic analysis of facioscapulohumeral muscular dystrophy by Nanopore long-read whole-genome sequencing
Published in Journal of translational medicine (13-05-2024)“…Facioscapulohumeral muscular dystrophy (FSHD) is a high-prevalence autosomal dominant neuromuscular disease characterized by significant clinical and genetic…”
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Icariside I – A novel inhibitor of the kynurenine-AhR pathway with potential for cancer therapy by blocking tumor immune escape
Published in Biomedicine & pharmacotherapy (01-09-2022)“…Although therapeutic antibodies against immune checkpoints such as PD-1/PD-L1 have achieved unprecedented success in clinical tumor patients, there are still…”
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Secretion of collagenases by Saccharomyces cerevisiae for collagen degradation
Published in Biotechnology for biofuels (28-08-2022)“…The production and processing of animal-based products generates many collagen-rich by-products, which have received attention both for exploitation to…”
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Correction: Secretion of collagenases by Saccharomyces cerevisiae for collagen degradation
Published in Biotechnology for biofuels (01-08-2023)Get full text
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