Search Results - "Huang, L Eric"

Impact of CDKN2A/B Homozygous Deletion on the Prognosis and Biology of IDH-Mutant Glioma by Huang, L Eric

“…Although hotspot mutations in isocitrate dehydrogenase (IDH) genes are associated with favorable clinical outcomes in glioma, homozygous deletion has been…”
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Prognostic role of mitochondrial pyruvate carrier in isocitrate dehydrogenase-mutant glioma by Karsy, Michael, Guan, Jian, Huang, L Eric

“…OBJECTIVE Gliomas are one of the most common types of primary brain tumors. Recent studies have supported the importance of key genetic alterations, including…”
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Hypoxia Facilitates Alzheimer's Disease Pathogenesis by Up-Regulating BACE1 Gene Expression by Sun, Xiulian, He, Guiqiong, Qing, Hong, Zhou, Weihui, Dobie, Frederick, Cai, Fang, Staufenbiel, Matthias, Huang, L. Eric, Song, Weihong

“…The molecular mechanism underlying the pathogenesis of the majority of cases of sporadic Alzheimer's disease (AD) is unknown. A history of stroke was found to…”
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Association of TP53 Alteration with Tissue Specificity and Patient Outcome of IDH1-Mutant Glioma by Murnyak, Balazs, Huang, L. Eric

“…Since the initial discovery of recurrent isocitrate dehydrogenase 1 (IDH1) mutations at Arg132 in glioma, IDH1 hotspot mutations have been identified in…”
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efam: an expanded, metaproteome-supported HMM profile database of viral protein families by Zayed, Ahmed A, Lücking, Dominik, Mohssen, Mohamed, Cronin, Dylan, Bolduc, Ben, Gregory, Ann C, Hargreaves, Katherine R, Piehowski, Paul D, White III, Richard A, Huang, Eric L, Adkins, Joshua N, Roux, Simon, Moraru, Cristina, Sullivan, Matthew B

“…Abstract Motivation Viruses infect, reprogram and kill microbes, leading to profound ecosystem consequences, from elemental cycling in oceans and soils to…”
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Bortezomib inhibits tumor adaptation to hypoxia by stimulating the FIH-mediated repression of hypoxia-inducible factor-1 by Shin, Dong Hoon, Chun, Yang-Sook, Lee, Dong Soon, Huang, L. Eric, Park, Jong-Wan

“…Bortezomib (PS-341), a proteasome inhibitor, has been examined clinically for the treatment of multiple myeloma and several solid tumors. Bortezomib directly…”
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Friend or foe—IDH1 mutations in glioma 10 years on by Huang, L Eric

“…Abstract The identification of recurrent point mutations in the isocitrate dehydrogenase 1 (IDH1) gene, albeit in only a small percentage of glioblastomas a…”
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Spatially-Resolved Proteomics: Rapid Quantitative Analysis of Laser Capture Microdissected Alveolar Tissue Samples by Clair, Geremy, Piehowski, Paul D., Nicola, Teodora, Kitzmiller, Joseph A., Huang, Eric L., Zink, Erika M., Sontag, Ryan L., Orton, Daniel J., Moore, Ronald J., Carson, James P., Smith, Richard D., Whitsett, Jeffrey A., Corley, Richard A., Ambalavanan, Namasivayam, Ansong, Charles

“…Laser capture microdissection (LCM)-enabled region-specific tissue analyses are critical to better understand complex multicellular processes. However, current…”
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Regulation of Hypoxia-Inducible Factor 1α is Mediated by an O2-dependent Degradation Domain via the Ubiquitin-Proteasome Pathway by Huang, L. Eric, Gu, Jie, Schau, Maureen, Bunn, H. Franklin

“…Hypoxia induces a group of physiologically important genes such as erythropoietin and vascular endothelial growth factor. These genes are transcriptionally…”
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SNaPP: Simplified Nanoproteomics Platform for Reproducible Global Proteomic Analysis of Nanogram Protein Quantities by Huang, Eric L, Piehowski, Paul D, Orton, Daniel J, Moore, Ronald J, Qian, Wei-Jun, Casey, Cameron P, Sun, Xiaofei, Dey, Sudhansu K, Burnum-Johnson, Kristin E, Smith, Richard D

“…Global proteomic analyses of complex protein samples in nanogram quantities require a fastidious approach to achieve in-depth protein coverage and quantitative…”
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Extracellular glutamate and IDH1R132H inhibitor promote glioma growth by boosting redox potential by Tiburcio, Patricia D. B., Gillespie, David L., Jensen, Randy L., Huang, L. Eric

“…Purpose Somatic mutations of the isocitrate dehydrogenase 1 ( IDH1 ) gene, mostly substituting Arg132 with histidine, are associated with better patient…”
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The neural stem-cell marker CD24 is specifically upregulated in IDH-mutant glioma by Tiburcio, Patricia D.B., Locke, Mary C., Bhaskara, Srividya, Chandrasekharan, Mahesh B., Huang, L. Eric

“…Malignant gliomas have disproportionally high morbidity and mortality. Heterozygous mutations in the isocitrate dehydrogenase 1 (IDH1) gene are most common in…”
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In Vivo Manipulation of HIF-1α Expression During Glioma Genesis by Tiburcio, Patricia D B, Lyne, Séan B, Eric Huang, L

“…Hypoxia has long been recognized as a driving force of tumor progression and therapeutic resistance, and the transcription factor HIF-1α is believed to play a…”
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Hypoxia-induced genetic instability--a calculated mechanism underlying tumor progression by Huang, L Eric, Bindra, Ranjit S, Glazer, Peter M, Harris, Adrian L

“…The cause of human cancers is imputed to the genetic alterations at nucleotide and chromosomal levels of ill-fated cells. It has long been recognized that…”
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Intermittent induction of HIF-1α produces lasting effects on malignant progression independent of its continued expression by Choi, Hyunsung, Gillespie, David L, Berg, Shauna, Rice, Christopher, Couldwell, Sandrine, Gu, Jie, Colman, Howard, Jensen, Randy L, Huang, L Eric

“…Dysregulation of hypoxia-inducible transcription factors HIF-1α and HIF-2α correlates with poor prognosis in human cancers; yet, divergent and sometimes…”
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The impact of hypoxia and mesenchymal transition on glioblastoma pathogenesis and cancer stem cells regulation by Karsy, Michael, MD, PhD, Guan, Jian, MD, Jensen, Randy, MD, PhD, Huang, L. Eric, MD, PhD, Colman, Howard, MD, PhD

“…Glioblastoma (GBM) is an aggressive primary brain tumor with potential for wide dissemination and resistance to standard treatments. Although GBM represents a…”
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An Essential Role for p300/CBP in the Cellular Response to Hypoxia by Arany, Zoltan, Huang, L. Eric, Eckner, Richard, Bhattacharya, Shoumo, Jiang, Chian, Goldberg, Mark A., Bunn, H. Franklin, Livingston, David M.

“…p300 and CBP are homologous transcription adapters targeted by the E1A oncoprotein. They participate in numerous biological processes, including cell cycle…”
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Hypoxic Suppression of the Cell Cycle Gene CDC25A in Tumor Cells by Hammer, Stefanie, To, Kenneth K.W., Yoo, Young-Gun, Koshiji, Minori, Huang, L. Eric

“…Hypoxia, a key microenvironmental factor for tumor development, not only stimulates angiogenesis and glycolysis for tumor expansion, but also induces cell…”
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Requirement of evading apoptosis for HIF-1α-induced malignant progression in mouse cells by Hayashi, Masami, Yoo, Young-Gun, Christensen, Jared, Huang, L. Eric

“…Tumor hypoxia is correlated with genetic alteration and malignant progression. Our previous studies indicated that the hypoxia-inducible transcription factor,…”
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Hypoxia-Inducible Factor-1 Transactivates Transforming Growth Factor-β3 in Trophoblast by Nishi, Hirotaka, Nakada, Toshihide, Hokamura, Mitsuyasu, Osakabe, Yumi, Itokazu, Osamu, Huang, L. Eric, Isaka, Keiichi

“…Hypoxia occurs during the development of placenta in the first trimester and is implicated in trophoblast differentiation. Intervillous blood flow increases…”
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