Search Results - "Huang, Jeffrey T. J."

Identification of Novel Pathways of Osimertinib Disposition and Potential Implications for the Outcome of Lung Cancer Therapy by MacLeod, A Kenneth, Lin, De, Huang, Jeffrey T-J, McLaughlin, Lesley A, Henderson, Colin J, Wolf, C Roland

“…Osimertinib is a third-generation inhibitor of the epidermal growth factor receptor used in treatment of non-small cell lung cancer. A full understanding of…”
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Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans by Knatko, Elena V, Ibbotson, Sally H, Zhang, Ying, Higgins, Maureen, Fahey, Jed W, Talalay, Paul, Dawe, Robert S, Ferguson, James, Huang, Jeffrey T-J, Clarke, Rosemary, Zheng, Suqing, Saito, Akira, Kalra, Sukirti, Benedict, Andrea L, Honda, Tadashi, Proby, Charlotte M, Dinkova-Kostova, Albena T

“…The transcription factor Nrf2 determines the ability to adapt and survive under conditions of electrophilic, oxidative, and inflammatory stress by regulating…”
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DHX9 helicase promotes R-loop formation in cells with impaired RNA splicing by Chakraborty, Prasun, Huang, Jeffrey T. J., Hiom, Kevin

“…R-loops are stable nucleic acid structures that have important physiological functions, but which also pose a significant threat to genomic stability…”
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Metabolic profiling of CSF: evidence that early intervention may impact on disease progression and outcome in schizophrenia by Holmes, Elaine, Tsang, Tsz M, Huang, Jeffrey T-J, Leweke, F Markus, Koethe, Dagmar, Gerth, Christoph W, Nolden, Brit M, Gross, Sonja, Schreiber, Daniela, Nicholson, Jeremy K, Bahn, Sabine

“…The identification of schizophrenia biomarkers is a crucial step towards improving current diagnosis, developing new presymptomatic treatments, identifying…”
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CSF metabolic and proteomic profiles in patients prodromal for psychosis by Huang, Jeffrey T-J, Leweke, F Markus, Tsang, Tsz M, Koethe, Dagmar, Kranaster, Laura, Gerth, Christoph W, Gross, Sonja, Schreiber, Daniela, Ruhrmann, Stephan, Schultze-Lutter, Frauke, Klosterkötter, Joachim, Holmes, Elaine, Bahn, Sabine

“…The initial prodromal state of psychosis (IPS) is defined as an early disease stage prior to the onset of overt psychosis characterized by sub-threshold or…”
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Neutrophil Elastase Activity Is Associated with Exacerbations and Lung Function Decline in Bronchiectasis by Chalmers, James D, Moffitt, Kelly L, Suarez-Cuartin, Guillermo, Sibila, Oriol, Finch, Simon, Furrie, Elizabeth, Dicker, Alison, Wrobel, Karolina, Elborn, J Stuart, Walker, Brian, Martin, S Lorraine, Marshall, Sara E, Huang, Jeffrey T-J, Fardon, Thomas C

“…Sputum neutrophil elastase and serum desmosine, which is a linked marker of endogenous elastin degradation, are possible biomarkers of disease severity and…”
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Quantitative urinary proteomics using stable isotope labelling by peptide dimethylation in patients with prostate cancer by Li, Chunhui, Zang, Tuo, Wrobel, Karolina, Huang, Jeffrey T.-J., Nabi, Ghulam

“…Prostate cancer (PCa) is the most commonly diagnosed malignancy in men. The current prevalent diagnosis method, prostate-specific antigen (PSA) screening test,…”
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Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action by Kostov, Rumen V., Knatko, Elena V., McLaughlin, Lesley A., Henderson, Colin J., Zheng, Suqing, Huang, Jeffrey T.-J., Honda, Tadashi, Dinkova-Kostova, Albena T.

“…The acetylenic tricyclic bis(cyanoenone) TBE-31 is a highly potent cysteine targeting compound with a reversible covalent mode of action; its…”
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Disease biomarkers in cerebrospinal fluid of patients with first-onset psychosis by Huang, Jeffrey T-J, Leweke, F Markus, Oxley, David, Wang, Lan, Harris, Nathan, Koethe, Dagmar, Gerth, Christoph W, Nolden, Brit M, Gross, Sonja, Schreiber, Daniela, Reed, Benjamin, Bahn, Sabine

“…Psychosis is a severe mental condition that is characterized by a loss of contact with reality and is typically associated with hallucinations and delusional…”
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GDF15 mediates the effects of metformin on body weight and energy balance by Coll, Anthony P., Chen, Michael, Taskar, Pranali, Rimmington, Debra, Patel, Satish, Tadross, John A., Cimino, Irene, Yang, Ming, Welsh, Paul, Virtue, Samuel, Goldspink, Deborah A., Miedzybrodzka, Emily L., Konopka, Adam R., Esponda, Raul Ruiz, Huang, Jeffrey T.-J., Tung, Y. C. Loraine, Rodriguez-Cuenca, Sergio, Tomaz, Rute A., Harding, Heather P., Melvin, Audrey, Yeo, Giles S. H., Preiss, David, Vidal-Puig, Antonio, Vallier, Ludovic, Nair, K. Sreekumaran, Wareham, Nicholas J., Ron, David, Gribble, Fiona M., Reimann, Frank, Sattar, Naveed, Savage, David B., Allan, Bernard B., O’Rahilly, Stephen

“…Metformin, the world’s most prescribed anti-diabetic drug, is also effective in preventing type 2 diabetes in people at high risk 1 , 2 . More than 60% of this…”
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A Targeted in Vivo SILAC Approach for Quantification of Drug Metabolism Enzymes: Regulation by the Constitutive Androstane Receptor by MacLeod, A. Kenneth, Zang, Tuo, Riches, Zoe, Henderson, Colin J, Wolf, C. Roland, Huang, Jeffrey T.-J

“…The modulation of drug metabolism enzyme (DME) expression by therapeutic agents is a central mechanism of drug–drug interaction and should be assessed as early…”
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Measurement of Urinary Total Desmosine and Isodesmosine Using Isotope-Dilution Liquid Chromatography-Tandem Mass Spectrometry by Albarbarawi, Osama, Barton, Alun, Lin, ZhaoSheng, Takahashi, Eddie, Buddharaju, Ajay, Brady, Jeffrey, Miller, Douglas, Palmer, Colin N. A, Huang, Jeffrey T.-J

“…The current LC-MS based desmosine/isodesmosine (DES/IDS) assays may be unsatisfactory for clinical use due to lack of an appropriate internal standard or low…”
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Simultaneous and high-throughput quantitation of urinary tetranor PGDM and tetranor PGEM by online SPE-LC-MS/MS as inflammatory biomarkers by Zhang, Yizhong, Zhang, Guodong, Clarke, Philip A., Huang, Jeffrey T. J., Takahashi, Eddie, Muirhead, David, Steenwyk, Rick C., Lin, Zhaosheng

“…Quantitation of urinary tetranor PGDM or tetranor PGEM (tPGDM and tPGEM) in the past was performed separately using off‐line SPE LC–MS/MS methods. The manual…”
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Neonicotinoids target distinct nicotinic acetylcholine receptors and neurons, leading to differential risks to bumblebees by Moffat, Christopher, Buckland, Stephen T., Samson, Andrew J., McArthur, Robin, Chamosa Pino, Victor, Bollan, Karen A., Huang, Jeffrey T.-J., Connolly, Christopher N.

“…There is growing concern over the risk to bee populations from neonicotinoid insecticides and the long-term consequences of reduced numbers of insect…”
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Stoichiometric Quantification of Akt Phosphorylation Using LC-MS/MS by Atrih, Abdelmadjid, Turnock, Dan, Sellar, Grant, Thompson, Alastair, Feuerstein, Giora, Ferguson, Michael A. J, Huang, Jeffrey T.-J

“…The Ptdlns-3-kinase (PI3-K) signaling pathway plays a vital role in cell survival, proliferation, apoptosis and differentiation in normal cells, as well as in…”
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Serum Desmosine Is Associated with Long-Term All-Cause and Cardiovascular Mortality in Bronchiectasis by Huang, Jeffrey T-J, Kuzmanova, Elena, Dicker, Alison J, Keir, Holly R, Finch, Simon, Aliberti, Stefano, Fardon, Thomas C, Chalmers, James D

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Novel Pathways of Ponatinib Disposition Catalyzed By CYP1A1 Involving Generation of Potentially Toxic Metabolites by Lin, De, Kostov, Rumen, Huang, Jeffrey T-J, Henderson, Colin J, Wolf, C Roland

“…Ponatinib, a pan-BCR-ABL tyrosine kinase inhibitor for the treatment of chronic myeloid leukemia (CML), causes severe side effects including vascular…”
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CSF biomarker discovery using label-free nano-LC-MS based proteomic profiling: Technical aspects by Huang, Jeffrey T.-J., McKenna, Therese, Hughes, Chris, Leweke, F. Markus, Schwarz, Emanuel, Bahn, Sabine

“…Biomarker discovery in cerebrospinal fluid (CSF) can provide important information helping to diagnose and monitor disease progression in brain disorders. We…”
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Metabolic Profiling of Plasma from Discordant Schizophrenia Twins:  Correlation between Lipid Signals and Global Functioning in Female Schizophrenia Patients by Tsang, Tsz M, Huang, Jeffrey T.-J, Holmes, Elaine, Bahn, Sabine

“…1H NMR spectroscopy-based metabonomic analysis was employed to investigate plasma samples from 21 pairs of monozygotic twins discordant for schizophrenia and 8…”
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High-Intensity Exercise as a Dishabituating Stimulus Restores Counterregulatory Responses in Recurrently Hypoglycemic Rodents by McNeilly, Alison D, Gallagher, Jennifer R, Huang, Jeffrey T-J, Ashford, Michael L J, McCrimmon, Rory J

“…Hypoglycemia is a major adverse effect of insulin therapy for people with type 1 diabetes (T1D). Profound defects in the normal counterregulatory response to…”
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