Search Results - "Huang, Huizhe"

Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity by Wang, Shuai, Dai, Tong, Qin, Ziran, Pan, Ting, Chu, Feng, Lou, Lingfeng, Zhang, Long, Yang, Bing, Huang, Huizhe, Lu, Huasong, Zhou, Fangfang

“…Patients with Coronavirus disease 2019 exhibit low expression of interferon-stimulated genes, contributing to a limited antiviral response. Uncovering the…”
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TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence by Ren, Jiang, Wang, Shuai, Zong, Zhi, Pan, Ting, Liu, Sijia, Mao, Wei, Huang, Huizhe, Yan, Xiaohua, Yang, Bing, He, Xin, Zhou, Fangfang, Zhang, Long

“…Viruses, as opportunistic intracellular parasites, hijack the cellular machinery of host cells to support their survival and propagation. Numerous viral…”
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PAX1 represses canonical Wnt signaling pathway and plays dual roles during endoderm differentiation by Miao, Danxiu, Ren, Jie, Jia, Yanhan, Jia, Yihui, Li, Yanshu, Huang, Huizhe, Gao, Rui

“…Paired box 1 (PAX1) is a transcription factor and essential for the development of pharyngeal pouches-derived tissues, including thymus. PAX1 mutations are…”
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Oxidative Stress and Endoplasmic Reticulum Stress Contributes to Arecoline and Its Secondary Metabolites-Induced Dyskinesia in Zebrafish Embryos by Yan, Wenhua, Zhang, Tian, Li, Shuaiting, Wang, Yunpeng, Zhu, Li, Cao, Yu, Lai, Xiaofang, Huang, Huizhe

“…Areca nut has been listed as one of the most addictive substances, along with tobacco, alcohol and caffeine. Areca nut contains seven psychoactive alkaloids;…”
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USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling by Zhou, Fangfang, Xie, Feng, Jin, Ke, Zhang, Zhengkui, Clerici, Marcello, Gao, Rui, van Dinther, Maarten, Sixma, Titia K, Huang, Huizhe, Zhang, Long, ten Dijke, Peter

“…SMAD4 is a common intracellular effector for TGF‐β family cytokines, but the mechanism by which its activity is dynamically regulated is unclear. We…”
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FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection by Dai, Tong, Wu, Liming, Wang, Shuai, Wang, Jing, Xie, Feng, Zhang, Zhengkui, Fang, Xiuwu, Li, Jingxian, Fang, Pengfei, Li, Fang, Jin, Ke, Dai, Jianfeng, Yang, Bing, Zhou, Fangfang, van Dam, Hans, Cai, Dachuan, Huang, Huizhe, Zhang, Long

“…Mitochondrial antiviral signaling protein (MAVS) is an adaptor of the innate immune receptor retinoic acid-inducible gene 1 (RIG-I) that links recognition of…”
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Ubiquitin-specific Protease 4 Mitigates Toll-like/Interleukin-1 Receptor Signaling and Regulates Innate Immune Activation by Zhou, FangFang, Zhang, Xiaofei, van Dam, Hans, ten Dijke, Peter, Huang, Huizhe, Zhang, Long

“…The Toll-like receptor (TLR)/IL-1 receptor (IL-1R) signaling pathway is essential for innate immune responses and immune homeostasis. Lys-63-polyubiquitinated…”
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Four novel mutations identification in 17 beta-hydroxysteroid dehydrogenase-3 deficiency and our clinical experience: possible benefits of early treatment by Wang, Yunpeng, Xu, Yu, Zhang, Huijiao, Yin, Danyang, Pan, Yiming, He, Xiwen, Li, Shuaiting, Cheng, Zhi, Zhu, Gaohui, Zhao, Ting, Huang, Huizhe, Zhu, Min

“…Individuals with 17-beta-hydroxysteroid dehydrogenase type 3 (17β-HSD3) deficiency face a multitude of challenges, primarily concerning genital appearance,…”
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Berberine Protects Against Palmitate-Induced Apoptosis in Tubular Epithelial Cells by Promoting Fatty Acid Oxidation by Sun, Jiye, Chen, Xuemei, Liu, Ting, Jiang, Xushun, Wu, Yue, Yang, Shan, Hua, Wei, Li, Zhengdong, Huang, Huizhe, Ruan, Xiongzhong, Du, Xiaogang

“…BACKGROUND Increased lipid accumulation in renal tubular epithelial cells (TECs) contributes to their injury and dysfunction and progression of…”
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RNF12 Controls Embryonic Stem Cell Fate and Morphogenesis in Zebrafish Embryos by Targeting Smad7 for Degradation by Zhang, Long, Huang, Huizhe, Zhou, FangFang, Schimmel, Joost, Pardo, Cristina Gontan, Zhang, Tingting, Barakat, Tahsin Stefan, Sheppard, Kelly-Ann, Mickanin, Craig, Porter, Jeff A., Vertegaal, Alfred C.O., van Dam, Hans, Gribnau, Joost, Lu, Chris X., ten Dijke, Peter

“…TGF-β members are of key importance during embryogenesis and tissue homeostasis. Smad7 is a potent antagonist of TGF-β family/Smad-mediated responses, but the…”
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Integrated Network Analysis of Symptom Clusters Across Monkeypox Epidemics From 1970 to 2023: Systematic Review and Meta-Analysis by Su, Shu, Jia, Meng, Yu, Yingni, Li, Hu, Yin, Wenwei, Lu, Yi, Huang, Rongzhong, Xiang, Rong, Huang, Huizhe, Hu, Peng

“…The worldwide spread of monkeypox (mpox) has witnessed a significant increase, particularly in nonendemic countries. We aimed to investigate the changing…”
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FLNA and PGK1 are Two Potential Markers for Progression in Hepatocellular Carcinoma by Ai, Jianzhong, Huang, Huizhe, Lv, Xiaoyan, Tang, Ziwei, Chen, Mianzhi, Chen, Tielin, Duan, Weiwei, Sun, Huan, Li, Qingwei, Tan, Ruizhi, Liu, Yuhang, Duan, Jingjing, Yang, Yang, Wei, Yuquan, Li, Yan, Zhou, Qin

“…Background/Aims: Hepatocellular carcinoma (HCC) is one of the most deadly diseases; metastasis and recurrence are the most important factors that affect the…”
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Identification of rare PTCH1 nonsense variant causing orofacial cleft in a Chinese family and an up-to-date genotype-phenotype analysis by Zhong, Wenjie, Zhao, Huaxiang, Huang, Wenbin, Zhang, Mengqi, Zhang, Qian, Zhang, Yue, Chen, Chong, Nueraihemaiti, Zulihumaer, Tuerhong, Dilifeire, Huang, Huizhe, Maimaitili, Gulibaha, Chen, Feng, Lin, Jiuxiang

“…The Patched 1 (PTCH1) gene encodes a membrane receptor involved in the Hedgehog (Hh) signaling pathway, an abnormal state of which may result in congenital…”
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Rnf25/AO7 positively regulates wnt signaling via disrupting Nkd1-Axin inhibitory complex independent of its ubiquitin ligase activity by Gao, Rui, Ma, Lin-Qiang, Du, Xiaogang, Zhang, Ting-Ting, Zhao, Liang, Liu, Luhong, Liu, Jing-Crystal, Guo, Fengjin, Cheng, Zhi, Huang, Huizhe

“…Wnt signaling components have been shown to control key events in embryogenesis and to maintain tissue homeostasis in the adult. Nkd1/2 and Axin1/2 protein…”
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TRAF4 mediates activation of TGF-β signaling and is a biomarker for oncogenesis in breast cancer by Zhou, FangFang, Li, Fang, Xie, Feng, Zhang, ZhengKui, Huang, HuiZhe, Zhang, Long

“…The tumor-promoting arm of transforming growth factor beta (TGF-β) receptor signaling contributes to advanced cancer progression and is considered a master…”
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Tob1 Controls Dorsal Development of Zebrafish Embryos by Antagonizing Maternal β-Catenin Transcriptional Activity by Xiong, Bo, Rui, Yanning, Zhang, Min, Shi, Kehui, Jia, Shunji, Tian, Tian, Yin, Kun, Huang, Huizhe, Lin, Shuyong, Zhao, Xingang, Chen, Yinghua, Chen, Ye-Guang, Lin, Sheng-Cai, Meng, Anming

“…Maternal β-catenin and Nodal signals are essential for the formation of the dorsal organizer, which, in turn, induces neural and other dorsal tissue…”
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Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation by Huang, Huizhe, Lu, Fu-I, Jia, Shunji, Meng, Shu, Cao, Ying, Wang, Yeqi, Ma, Weiping, Yin, Kun, Wen, Zilong, Peng, Jingrong, Thisse, Christine, Thisse, Bernard, Meng, Anming

“…Angiomotin (Amot), the founding member of the Motin family, is involved in angiogenesis by regulating endothelial cell motility, and is required for visceral…”
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PKHD1 post-transcriptionally modulated by miR-365-1 inhibits cell-cell adhesion by Duan, Jingjing, Huang, Huizhe, Lv, Xiaoyan, Wang, Honglian, Tang, Ziwei, Sun, Huan, Li, Qingwei, Ai, Jianzhong, Tan, Ruizhi, Liu, Yuhang, Chen, Mianzhi, Duan, Weiwei, Wei, Yuquan, Zhou, Qin

“…Autosomal recessive polycystic kidney disease (ARPKD) is a severe inherited disorder with an incidence of 1/20 000 live births. Mutations of PKHD1 (polycystic…”
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Chest CT Findings in Patients With Coronavirus Disease 2019 and Its Relationship With Clinical Features by Wu, Jiong, Wu, Xiaojia, Zeng, Wenbing, Guo, Dajing, Fang, Zheng, Chen, Linli, Huang, Huizhe, Li, Chuanming

“…OBJECTIVESThe aim of this study was to investigate the chest computed tomography (CT) findings in patients with confirmed coronavirus disease 2019 (COVID-19)…”
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Engineering Extracellular Vesicles Enriched with Palmitoylated ACE2 as COVID‐19 Therapy by Xie, Feng, Su, Peng, Pan, Ting, Zhou, Xiaoxue, Li, Heyu, Huang, Huizhe, Wang, Aijun, Wang, Fangwei, Huang, Jun, Yan, Haiyan, Zeng, Linghui, Zhang, Long, Zhou, Fangfang

“…Angiotensin converting enzyme 2 (ACE2) is a key receptor present on cell surfaces that directly interacts with the viral spike (S) protein of the severe acute…”
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