Search Results - "Huang, Hsueh‐Cheng"

Short‐duration treatment with elbasvir/grazoprevir and sofosbuvir for hepatitis C: A randomized trial by Lawitz, Eric, Poordad, Fred, Gutierrez, Julio A., Wells, Jennifer T., Landaverde, Carmen E., Evans, Barbara, Howe, Anita, Huang, Hsueh‐Cheng, Li, Jerry Jing, Hwang, Peggy, Dutko, Frank J., Robertson, Michael, Wahl, Janice, Barr, Eliav, Haber, Barbara

“…Direct‐acting antiviral agents (DAAs) represent the standard of care for patients with hepatitis C virus (HCV) infection. Combining DAAs with different…”
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Grazoprevir, ruzasvir, and uprifosbuvir for hepatitis C virus after NS5A treatment failure by Wyles, David, Wedemeyer, Heiner, Ben‐Ari, Ziv, Gane, Edward J., Hansen, Jesper Bach, Jacobson, Ira M., Laursen, Alex L., Luetkemeyer, Annie, Nahass, Ronald, Pianko, Stephen, Zeuzem, Stefan, Jumes, Patricia, Huang, Hsueh‐Cheng, Butterton, Joan, Robertson, Michael, Wahl, Janice, Barr, Eliav, Joeng, Hee‐Koung, Martin, Elizabeth, Serfaty, Lawrence

“…People with hepatitis C virus (HCV) infection who have failed treatment with an all‐oral regimen represent a challenging treatment population. The present…”
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Cyclic-Disulfide-Based Prodrugs for Cytosol-Specific Drug Delivery by Butora, Gabor, Qi, Ning, Fu, Wenlang, Nguyen, Truyen, Huang, Hsueh-Cheng, Davies, Ian W.

“…The cytosolic conversion of therapeutically relevant nucleosides into bioactive triphosphates is often hampered by the inefficiency of the first…”
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Elbasvir-Grazoprevir to Treat Hepatitis C Virus Infection in Persons Receiving Opioid Agonist Therapy: A Randomized Trial by Dore, Gregory J, Altice, Frederick, Litwin, Alain H, Dalgard, Olav, Gane, Edward J, Shibolet, Oren, Luetkemeyer, Anne, Nahass, Ronald, Peng, Cheng-Yuan, Conway, Brian, Grebely, Jason, Howe, Anita Y M, Gendrano, Isaias N, Chen, Erluo, Huang, Hsueh-Cheng, Dutko, Frank J, Nickle, David C, Nguyen, Bach-Yen, Wahl, Janice, Barr, Eliav, Robertson, Michael N, Platt, Heather L

“…Hepatitis C virus (HCV) infection is common in persons who inject drugs (PWID). To evaluate elbasvir-grazoprevir in treating HCV infection in PWID. Randomized,…”
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Novel intramolecular aminohydroxylation toward the syntheses of 2′-amino-2′-ethynyl nucleosides by Huang, Yuhua, Bennett, Frank, Buevich, Alexei, Girijavallabhan, Vinay, Kerekes, Angela D., Huang, Hsueh-Cheng, Tawa, Paul, Bogen, Stephane L., Davies, Ian W.

“…[Display omitted] •Tertiary amino nucleoside via tethered aminohydroxylation.•Diastereospecificity.•Nucleosides bearing ethynyl/amino at the C2′ position…”
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Ube3a unsilencer for the potential treatment of Angelman syndrome by Vihma, Hanna, Li, Kelin, Welton-Arndt, Anna, Smith, Audrey L., Bettadapur, Kiran R., Gilmore, Rachel B., Gao, Eric, Cotney, Justin L., Huang, Hsueh-Cheng, Collins, Jon L., Chamberlain, Stormy J., Lee, Hyeong-Min, Aubé, Jeffrey, Philpot, Benjamin D.

“…Deletion of the maternal UBE3A allele causes Angelman syndrome (AS) ; because paternal UBE3A is epigenetically silenced by a long non-coding antisense (…”
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Concise syntheses and HCV NS5B polymerase inhibition of (2′R)-3 and (2′S)-2′-ethynyluridine-10 and related nucleosides by Bennett, Frank, Buevich, Alexei V., Huang, Hsueh-Cheng, Girijavallabhan, Vinay, Kerekes, Angela D., Huang, Yuhua, Malikzay, Asra, Smith, Elizabeth, Ferrari, Eric, Senior, Mary, Osterman, Rebecca, Wang, Lingyan, Wang, Jun, Pu, Haiyan, Truong, Quang T., Tawa, Paul, Bogen, Stephane L., Davies, Ian W., Weber, Ann E.

“…[Display omitted] (2′R)-Ethynyl uridine 3, and its (2′S)-diastereomer 10, are synthesised in a divergent fashion from the inexpensive parent nucleoside. Both…”
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Structure–Activity Relationship (SAR) Development and Discovery of Potent Indole-Based Inhibitors of the Hepatitis C Virus (HCV) NS5B Polymerase by Chen, Kevin X, Vibulbhan, Bancha, Yang, Weiying, Sannigrahi, Mousumi, Velazquez, Francisco, Chan, Tin-Yau, Venkatraman, Srikanth, Anilkumar, Gopinadhan N, Zeng, Qingbei, Bennet, Frank, Jiang, Yueheng, Lesburg, Charles A, Duca, Jose, Pinto, Patrick, Gavalas, Stephen, Huang, Yuhua, Wu, Wanli, Selyutin, Oleg, Agrawal, Sony, Feld, Boris, Huang, Hsueh-Cheng, Li, Cheng, Cheng, Kuo-Chi, Shih, Neng-Yang, Kozlowski, Joseph A, Rosenblum, Stuart B, Njoroge, F. George

“…Starting with the indole-based C-3 pyridone lead HCV polymerase inhibitor 2, extensive SAR studies were performed at different positions of the indole core…”
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A Novel Class of Highly Potent Irreversible Hepatitis C Virus NS5B Polymerase Inhibitors by Chen, Kevin X, Lesburg, Charles A, Vibulbhan, Bancha, Yang, Weiying, Chan, Tin-Yau, Venkatraman, Srikanth, Velazquez, Francisco, Zeng, Qingbei, Bennett, Frank, Anilkumar, Gopinadhan N, Duca, Jose, Jiang, Yueheng, Pinto, Patrick, Wang, Li, Huang, Yuhua, Selyutin, Oleg, Gavalas, Stephen, Pu, Haiyan, Agrawal, Sony, Feld, Boris, Huang, Hsueh-Cheng, Li, Cheng, Cheng, Kuo-Chi, Shih, Neng-Yang, Kozlowski, Joseph A, Rosenblum, Stuart B, Njoroge, F. George

“…Starting from indole-based C-3 pyridone HCV NS5B polymerase inhibitor 2, structure–activity relationship (SAR) investigations of the indole N-1 benzyl moiety…”
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Optimization of potency and pharmacokinetics of tricyclic indole derived inhibitors of HCV NS5B polymerase. Identification of ester prodrugs with improved oral pharmacokinetics by Venkatraman, Srikanth, Velazquez, Francisco, Gavalas, Stephen, Wu, Wanli, Chen, Kevin X., Nair, Anilkumar G., Bennett, Frank, Huang, Yuhua, Pinto, Patrick, Jiang, Yueheng, Selyutin, Oleg, Vibulbhan, Bancha, Zeng, Qingbei, Lesburg, Charles, Duca, Jose, Heimark, Larry, Huang, Hsueh-Cheng, Agrawal, Sony, Jiang, Chuan-kui, Ferrari, Eric, Li, Cheng, Kozlowski, Joseph, Rosenblum, Stuart, Shih, Neng-Yang, Njoroge, F. George

“…HCV infections are the leading causes for hepatocellular carcinoma and liver transplantation in the United States. Recent advances in drug discovery have…”
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Discovery of novel tricyclic indole derived inhibitors of HCV NS5B RNA dependent RNA polymerase by Venkatraman, Srikanth, Velazquez, Francisco, Gavalas, Stephen, Wu, Wanli, Chen, Kevin X., Nair, Anilkumar G., Bennett, Frank, Huang, Yuhua, Pinto, Patrick, Jiang, Yueheng, Selyutin, Oleg, Vibulbhan, Bancha, Zeng, Qingbei, Lesburg, Charles, Duca, Jose, Huang, Hsueh-Cheng, Agrawal, Sony, Jiang, Chuan-kui, Ferrari, Eric, Li, Cheng, Kozlowski, Joseph, Rosenblum, Stuart, Shih, Neng-Yang, Njoroge, F. George

“…The characterization of HCV genome has identified various vital functional proteins involved in the life cycle of hepatitis C virus. This has resulted in many…”
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Discovery of an irreversible HCV NS5B polymerase inhibitor by Zeng, Qingbei, Nair, Anilkumar G., Rosenblum, Stuart B., Huang, Hsueh-Cheng, Lesburg, Charles A., Jiang, Yueheng, Selyutin, Oleg, Chan, Tin-Yau, Bennett, Frank, Chen, Kevin X., Venkatraman, Srikanth, Sannigrahi, Mousumi, Velazquez, Francisco, Duca, Jose S., Gavalas, Stephen, Huang, Yuhua, Pu, Haiyan, Wang, Li, Pinto, Patrick, Vibulbhan, Bancha, Agrawal, Sony, Ferrari, Eric, Jiang, Chuan-kui, Li, Cheng, Hesk, David, Gesell, Jennifer, Sorota, Steve, Shih, Neng-Yang, Njoroge, F. George, Kozlowski, Joseph A.

“…The discovery of lead compound 2e was described. Its covalent binding to HCV NS5B polymerase enzyme was investigated by X-ray analysis. The results of…”
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A novel hepatitis C virus NS5B polymerase assay of de novo initiated RNA synthesis directed from a heteropolymeric RNA template by Ferrari, Eric, Huang, Hsueh-Cheng

“…The hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase is essential for viral replication and a clinically validated antiviral target. Discovery of HCV…”
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5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors by Arasappan, Ashok, Bennett, Frank, Girijavallabhan, Vinay, Huang, Yuhua, Huelgas, Regina, Alvarez, Carmen, Chen, Lei, Gavalas, Stephen, Kim, Seong-Heon, Kosinski, Aneta, Pinto, Patrick, Rizvi, Razia, Rossman, Randall, Shankar, Bandarpalle, Tong, Ling, Velazquez, Francisco, Venkatraman, Srikanth, Verma, Vishal A., Kozlowski, Joseph, Shih, Neng-Yang, Piwinski, John J., MacCoss, Malcolm, Kwong, Cecil D., Clark, Jeremy L., Fowler, Anita T., Geng, Feng, Kezar, Hollis S., Roychowdhury, Abhijit, Reynolds, Robert C., Maddry, Joseph A., Ananthan, Subramaniam, Secrist, John A., Li, Cheng, Chase, Robert, Curry, Stephanie, Huang, Hsueh-Cheng, Tong, Xiao, Njoroge, F. George

“…Based on a previously identified HCV replication (replicase) inhibitor 1, SAR efforts were conducted around the pyrimidine core to improve the potency and…”
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Novel substituted pyrimidines as HCV replication (replicase) inhibitors by Kwong, Cecil D., Clark, Jeremy L., Fowler, Anita T., Geng, Feng, Kezar, Hollis S., Roychowdhury, Abhijit, Reynolds, Robert C., Maddry, Joseph A., Ananthan, Subramaniam, Secrist, John A., Shih, Neng-Yang, Piwinski, John J., Li, Cheng, Feld, Boris, Huang, Hsueh-Cheng, Tong, Xiao, George Njoroge, F., Arasappan, Ashok

“…Compound 1 was identified as a HCV replication inhibitor from screening/early SAR triage. Potency improvement was achieved via modulation of substituent on the…”
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Synthesis and SAR of geminal substitutions at the C5′ carbosugar position of pyrimidine-derived HCV inhibitors by Verma, Vishal A., Rossman, Randall, Bennett, Frank, Chen, Lei, Gavalas, Stephen, Girijavallabhan, Vinay, Huang, Yuhua, Kim, Seong-Heon, Kosinski, Aneta, Pinto, Patrick, Rizvi, Razia, Shankar, Bandarpalle, Tong, Ling, Velazquez, Francisco, Venkatraman, Srikanth, Kozlowski, Joseph, MacCoss, Malcolm, Kwong, Cecil D., Bansal, Namita, Kezar, Hollis S., Reynolds, Robert C., Maddry, Joseph A., Ananthan, Subramaniam, Secrist, John A., Li, Cheng, Chase, Robert, Curry, Stephanie, Huang, Hsueh-Cheng, Tong, Xiao, Njoroge, F. George, Arasappan, Ashok

“…The installation of geminal substitution at the C5′ position of the carbosugar in our pyrimidine-derived hepatitis C inhibitor series is reported. SAR studies…”
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Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors by Girijavallabhan, Vinay M., Alvarez, Carmen, Bennett, Frank, Chen, Lei, Gavalas, Stephen, Huang, Yuhua, Kim, Seong-Heon, Kosinski, Aneta, Pinto, Patrick, Rizvi, Razia, Rossman, Randall, Shankar, Bandarpalle, Tong, Ling, Velazquez, Francisco, Venkatraman, Srikanth, Verma, Vishal A., Kozlowski, Joseph, Shih, Neng-Yang, Piwinski, John J., MacCoss, Malcolm, Kwong, Cecil D., Bansal, Namita, Clark, Jeremy L., Fowler, Anita T., Kezar, Hollis S., Valiyaveettil, Jacob, Reynolds, Robert C., Maddry, Joseph A., Ananthan, Subramaniam, Secrist, John A., Li, Cheng, Chase, Robert, Curry, Stephanie, Huang, Hsueh-Cheng, Tong, Xiao, Njoroge, F. George, Arasappan, Ashok

“…Introduction of a nitrogen atom into the benzene ring of a previously identified HCV replication (replicase) benzothiazole inhibitor 1, resulted in the…”
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Cyclic-Disulfide-Based Prodrugs for Cytosol-Specific Drug Delivery by Butora, Gabor, Qi, Ning, Fu, Wenlang, Nguyen, Truyen, Huang, Hsueh-Cheng, Davies, Ian W.

“…The cytosolic conversion of therapeutically relevant nucleosides into bioactive triphosphates is often hampered by the inefficiency of the first…”
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Pyridofuran substituted pyrimidine derivatives as HCV replication (replicase) inhibitors by Bennett, Frank, Kezar, Hollis S., Girijavallabhan, Vinay, Huang, Yuhua, Huelgas, Regina, Rossman, Randall, Shih, Neng-Yang, Piwinski, John J., MacCoss, Malcolm, Kwong, Cecil D., Clark, Jeremy L., Fowler, Anita T., Geng, Feng, Roychowdhury, Abhijit, Reynolds, Robert C., Maddry, Joseph A., Ananthan, Subramaniam, Secrist, John A., Li, Cheng, Chase, Robert, Curry, Stephanie, Huang, Hsueh-Cheng, Tong, Xiao, George Njoroge, F., Arasappan, Ashok

“…Introduction of nitrogen atom into the benzene ring of a previously identified HCV replication (replicase) benzofuran inhibitor 2, resulted in the discovery of…”
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Discovery of SCH 900188: A Potent Hepatitis C Virus NS5B Polymerase Inhibitor Prodrug As a Development Candidate by Chen, Kevin X, Venkatraman, Srikanth, Anilkumar, Gopinadhan N, Zeng, Qingbei, Lesburg, Charles A, Vibulbhan, Bancha, Velazquez, Francisco, Chan, Tin-Yau, Bennet, Frank, Jiang, Yueheng, Pinto, Patrick, Huang, Yuhua, Selyutin, Oleg, Agrawal, Sony, Huang, Hsueh-Cheng, Li, Cheng, Cheng, Kuo-Chi, Shih, Neng-Yang, Kozlowski, Joseph A, Rosenblum, Stuart B, Njoroge, F. George

“…Starting from indole-based hepatitis C virus (HCV) NS5B polymerase inhibitor lead compound 1, structure modifications were performed at multiple indole…”
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