Search Results - "Huang, Hanxia"

A genome-wide association study of hypertension and blood pressure in African Americans by Adeyemo, Adebowale, Gerry, Norman, Chen, Guanjie, Herbert, Alan, Doumatey, Ayo, Huang, Hanxia, Zhou, Jie, Lashley, Kerrie, Chen, Yuanxiu, Christman, Michael, Rotimi, Charles

“…The evidence for the existence of genetic susceptibility variants for the common form of hypertension ("essential hypertension") remains weak and inconsistent…”
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FTO Genetic Variation and Association With Obesity in West Africans and African Americans by ADEYEMO, Adebowale, GUANJIE CHEN, JIE ZHOU, SHRINER, Daniel, DOUMATEY, Ayo, HANXIA HUANG, ROTIMI, Charles

“…The FTO gene is one of the most consistently replicated loci for obesity. However, data from populations of African ancestry are limited. We evaluated genetic…”
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Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans by CHEN, Guanjie, BENTLEY, Amy, HERBERT, Alan, CHRISTMAN, Michael, ROTIMI, Charles, ADEYEMO, Adebowale, SHRINER, Daniel, JIE ZHOU, DOUMATEY, Ayo, HANXIA HUANG, RAMOS, Edward, ERDOS, Michael, GERRY, Norman

“…Insulin resistance (IR) is a key determinant of type 2 diabetes (T2D) and other metabolic disorders. This genome-wide association study (GWAS) was designed to…”
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Identification, Genetic Characterization and Validation of Highly Diverse HIV-1 Viruses for Reference Panel Development by Zhao, Jiangqin, Huang, Hanxia, Lee, Sherwin, Ragupathy, Viswanath, Biswas, Santanu, Mbondji-wonje, Christelle, Wang, Xue, Jiang, Alex, Hewlett, Indira

“…The continued diversification of HIV poses potentially significant challenges to HIV diagnostics and therapeutics. The dynamic evolution of emerging variants…”
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The Roles of IL-6, IL-10, and IL-1RA in Obesity and Insulin Resistance in African-Americans by Charles, Bashira A, Doumatey, Ayo, Huang, Hanxia, Zhou, Jie, Chen, Guanjie, Shriner, Daniel, Adeyemo, Adebowale, Rotimi, Charles N

“…Objective: The aim of the study was to investigate the associations between IL-1 receptor antagonist (IL-1RA), IL-6, IL-10, measures of obesity, and insulin…”
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Circulating Adiponectin Is Associated with Obesity and Serum Lipids in West Africans by Meilleur, Katherine G., Doumatey, Ayo, Huang, Hanxia, Charles, Bashira, Chen, Guanjie, Zhou, Jie, Shriner, Daniel, Adeyemo, Adebowale, Rotimi, Charles

“…Context: Adiponectin, a hormone secreted by adipose tissue, has both metabolic and antiinflammatory properties. Although multiple studies have described the…”
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A genome-wide association study of serum uric acid in African Americans by Charles, Bashira A, Shriner, Daniel, Doumatey, Ayo, Chen, Guanjie, Zhou, Jie, Huang, Hanxia, Herbert, Alan, Gerry, Norman P, Christman, Michael F, Adeyemo, Adebowale, Rotimi, Charles N

“…Uric acid is the primary byproduct of purine metabolism. Hyperuricemia is associated with body mass index (BMI), sex, and multiple complex diseases including…”
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Hemin activation abrogates Mycoplasma hyorhinis replication in chronically infected prostate cancer cells via heme oxygenase‐1 induction by Huang, Hanxia, Dabrazhynetskaya, Alena, Pluznik, Jacob, Zheng, Jiwen, Wu, Yong, Chizhikov, Vladimir, Buehler, Paul W., Yamada, Kenneth M., Dhawan, Subhash

“…Mycoplasma hyorhinis (M. hyorhinis) lacks a cell wall and resists multiple antibiotics. We describe here the striking > 90% inhibitory effect of hemin, a…”
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UGT1A1 is a major locus influencing bilirubin levels in African Americans by CHEN, Guanjie, RAMOS, Edward, BENTLEY, Amy R, HUICHUN XU, CHARLES, Bashira A, CHRISTMAN, Michael F, ROTIMI, Charles N, ADEYEMO, Adebowale, SHRINER, Daniel, JIE ZHOU, DOUMATEY, Ayo P, HUANG, Hanxia, ERDOS, Michael R, GERRY, Norman P, HERBERT, Alan

“…Total serum bilirubin is associated with several clinical outcomes, including cardiovascular disease, diabetes and drug metabolism. We conducted a genome-wide…”
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Association of ATP1B1, RGS5 and SELE polymorphisms with hypertension and blood pressure in African–Americans by Faruque, Mezbah U, Chen, Guanjie, Doumatey, Ayo, Huang, Hanxia, Zhou, Jie, Dunston, Georgia M, Rotimi, Charles N, Adeyemo, Adebowale A

“…OBJECTIVEAlthough an increasing number of hypertension-associated genetic variants is being reported, replication of these findings in independent studies has…”
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Gene-based sequencing identifies lipid-influencing variants with ethnicity-specific effects in African Americans by Bentley, Amy R, Chen, Guanjie, Shriner, Daniel, Doumatey, Ayo P, Zhou, Jie, Huang, Hanxia, Mullikin, James C, Blakesley, Robert W, Hansen, Nancy F, Bouffard, Gerard G, Cherukuri, Praveen F, Maskeri, Baishali, Young, Alice C, Adeyemo, Adebowale, Rotimi, Charles N

“…Although a considerable proportion of serum lipids loci identified in European ancestry individuals (EA) replicate in African Americans (AA), interethnic…”
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C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans by DOUMATEY, Ayo P, GUANJIE CHEN, JOHNSON, Thomas, OLI, Johnnie, OKAFOR, Godfrey, AMOAH, Albert, EGHAN, Benjamin A, AGYENIM-BOATENG, Kofi, ACHEAMPONG, Joseph, ADEBAMOWO, Clement, GERRY, Norman P, CHRISTMAN, Michael F, TEKOLA AYELE, Fasil, ADEYEMO, Adebowale, ROTIMI, Charles N, JIE ZHOU, ERDOS, Michael, SHRINER, Daniel, HANXIA HUANG, ADELEYE, Jokotade, BALOGUN, Williams, FASANMADE, Olufemi

“…C-reactive protein (CRP) is an acute phase reactant protein produced primarily by the liver. Circulating CRP levels are influenced by genetic and non-genetic…”
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Transferability and fine-mapping of genome-wide associated loci for adult height across human populations by Shriner, Daniel, Adeyemo, Adebowale, Gerry, Norman P, Herbert, Alan, Chen, Guanjie, Doumatey, Ayo, Huang, Hanxia, Zhou, Jie, Christman, Michael F, Rotimi, Charles N

“…Human height is the prototypical polygenic quantitative trait. Recently, several genetic variants influencing adult height were identified, primarily in…”
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A Genome-Wide Search for Linkage to Renal Function Phenotypes in West Africans With Type 2 Diabetes by Chen, Guanjie, MD, Adeyemo, Adebowale A., MD, Zhou, Jie, BS, Chen, Yuanxiu, MD, PhD, Doumatey, Ayo, MS, Lashley, Kerrie, BS, Huang, Hanxia, MD, Amoah, Albert, MD, PhD, Agyenim-Boateng, Kofi, MD, Eghan, Benjamin A., MD, Okafor, Godfrey, MD, Acheampong, Joseph, MD, Oli, Johnnie, MD, Fasanmade, Olufemi, MD, Johnson, Thomas, MD, Rotimi, Charles, PhD

“…Background Reduced renal function often is a major consequence of diabetes and hypertension. Although several indices of renal function (eg, creatinine…”
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Transferability and fine mapping of genome-wide associated loci for lipids in African Americans by Adeyemo, Adebowale, Bentley, Amy R, Meilleur, Katherine G, Doumatey, Ayo P, Chen, Guanjie, Zhou, Jie, Shriner, Daniel, Huang, Hanxia, Herbert, Alan, Gerry, Norman P, Christman, Michael F, Rotimi, Charles N

“…A recent, large genome-wide association study (GWAS) of European ancestry individuals has identified multiple genetic variants influencing serum lipids…”
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Multiple loci associated with renal function in African Americans by Shriner, Daniel, Herbert, Alan, Doumatey, Ayo P, Zhou, Jie, Huang, Hanxia, Erdos, Michael R, Chen, Guanjie, Gerry, Norman P, Christman, Michael F, Adeyemo, Adebowale, Rotimi, Charles N

“…The incidence of chronic kidney disease varies by ethnic group in the USA, with African Americans displaying a two-fold higher rate than European Americans…”
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Global Gene Expression Profiling in Omental Adipose Tissue of Morbidly Obese Diabetic African Americans by Doumatey, Ayo P, Xu, Huichun, Huang, Hanxia, Trivedi, Niraj S, Lei, Lin, Elkahloun, Abdel, Adeyemo, Adebowale, Rotimi, Charles N

“…Adipose tissues play important role in the pathophysiology of obesity-related diseases including type 2 diabetes (T2D). To describe gene expression patterns…”
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Genomewide Scan and Fine Mapping of Quantitative Trait Loci for Intraocular Pressure on 5q and 14q in West Africans by Rotimi, Charles N, Chen, Guanjie, Adeyemo, Adebowale A, Jones, Leslie S, Agyenim-Boateng, Kofi, Eghan, Benjamin A., Jr, Zhou, Jie, Doumatey, Ayo, Lashley, Karrie, Huang, Hanxia, Fasanmade, Olufemi, Akinsola, Folasade B, Ezepue, Felix, Amoah, Albert, Akafo, Stephen, Chen, Yuanxiu, Oli, Johnnie, Johnson, Thomas

“…High intraocular pressure (IOP) is a major risk factor for glaucoma, one of the leading causes of blindness worldwide. Because it has been demonstrated that…”
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Development of admixture mapping panels for African Americans from commercial high-density SNP arrays by Chen, Guanjie, Shriner, Daniel, Zhou, Jie, Doumatey, Ayo, Huang, Hanxia, Gerry, Norman P, Herbert, Alan, Christman, Michael F, Chen, Yuanxiu, Dunston, Georgia M, Faruque, Mezbah U, Rotimi, Charles N, Adeyemo, Adebowale

“…Admixture mapping is a powerful approach for identifying genetic variants involved in human disease that exploits the unique genomic structure in recently…”
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RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucose by Zhang, Guofeng, Hirai, Hiroki, Cai, Tao, Miura, Junnosuke, Yu, Ping, Huang, Hanxia, Schiller, Martin R, Swaim, William D, Leapman, Richard D, Notkins, Abner L

“…The regulated endocrine-specific protein, RESP18, first found in the rat pituitary, was thought to be regulated by dopaminergic drugs. Bioinformatics studies…”
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