Search Results - "Huang, Gangxiong"

miR-20a Encoded by the miR-17―92 Cluster Increases the Metastatic Potential of Osteosarcoma Cells by Regulating Fas Expression by GANGXIONG HUANG, NISHIMOTO, Kazumasa, ZHICHAO ZHOU, HUGHES, Dennis, KLEINERMAN, Eugenie S

“…The ability of osteosarcoma cells to form lung metastases has been inversely correlated to cell surface Fas expression. Downregulation of Fas allows…”
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miR-20a Regulates FAS Expression in Osteosarcoma Cells by Modulating FAS Promoter Activity and Can be Therapeutically Targeted to Inhibit Lung Metastases by Yang, Yuanzheng, Huang, Gangxiong, Zhou, Zhichao, Fewell, Jason G, Kleinerman, Eugenie S

“…The metastatic potential of osteosarcoma cells is inversely correlated to cell surface FAS expression. Downregulation of FAS allows osteosarcoma cells to…”
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Genetically Modified T cells Targeting Interleukin-11 Receptor α-Chain Kill Human Osteosarcoma Cells and Induce the Regression of Established Osteosarcoma Lung Metastases by GANGXIONG HUANG, LING YU, COOPER, Laurence J. N, HOLLOMON, Mario, HULS, Helen, KLEINERMAN, Eugenie S

“…The treatment of osteosarcoma pulmonary metastases remains a challenge. T cells genetically modified to express a chimeric antigen receptor (CAR), which…”
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B7-H3 specific T cells with chimeric antigen receptor and decoy PD-1 receptors eradicate established solid human tumors in mouse models by Huang, Baozhu, Luo, Liqun, Wang, Jun, He, Bailin, Feng, Rui, Xian, Na, Zhang, Qiong, Chen, Lieping, Huang, Gangxiong

“…The application of chimeric antigen receptor (CAR)-T cell therapy in patients with advanced solid tumors remains a significant challenge. Simultaneously…”
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Effect of entinostat on NK cell-mediated cytotoxicity against osteosarcoma cells and osteosarcoma lung metastasis by Kiany, Simin, Huang, Gangxiong, Kleinerman, Eugenie S.

“…There is a crucial need for a new therapeutic approach for osteosarcoma (OS) lung metastasis since this disease remains the main cause of mortality in OS. We…”
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PD-1H Expression Associated With CD68 Macrophage Marker Confers an Immune-Activated Microenvironment and Favorable Overall Survival in Human Esophageal Squamous Cell Carcinoma by Chen, Yuangui, Feng, Rui, He, Bailin, Wang, Jun, Xian, Na, Huang, Gangxiong, Zhang, Qiuyu

“…Esophageal squamous cell carcinoma (ESCC) is the most common type of esophageal carcinoma (EC) in China. Although the PD-1 inhibitor pembrolizumab has been…”
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Ablation of T cell-associated PD-1H enhances functionality and promotes adoptive immunotherapy by Hu, Li, Chen, Ling, Xiao, Zexiu, Zheng, Xu, Chen, Yuangui, Xian, Na, Cho, Christina, Luo, Liqun, Huang, Gangxiong, Chen, Lieping

“…Programmed death-1 homolog (PD-1H) is a coinhibitory molecule that negatively regulates T cell-mediated immune responses. In this study, we determined whether…”
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Expression of human glutathione S-transferase P1 mediates the chemosensitivity of osteosarcoma cells by Huang, Gangxiong, Mills, Lisa, Worth, Laura L

“…Chemoresistance is a major reason that patients with osteosarcoma fail to achieve a lasting chemotherapy response, and it contributes to disease relapse,…”
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CAPER‐α alternative splicing regulates the expression of vascular endothelial growth factor165 in Ewing sarcoma cells by Huang, Gangxiong, Zhou, Zhichao, Wang, Hua, Kleinerman, Eugenie S.

“…BACKGROUND: TC‐71 Ewing sarcoma cells overexpress vascular endothelial growth factor (VEGF) with a shift from the 189 to the 165 isoform. METHODS: The effect…”
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Identification of Residues Important for Ligand Binding of Thromboxane A2 Receptor in the Second Extracellular Loop Using the NMR Experiment-guided Mutagenesis Approach by So, Shui-Ping, Wu, Jiaxin, Huang, Gangxiong, Huang, Aimin, Li, Dawei, Ruan, Ke-He

“…The second extracellular loop (eLP2) of the thromboxane A 2 receptor (TP) had been proposed to be involved in ligand binding. Through two-dimensional 1 H NMR…”
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Prostacyclin is an autocrine regulator in the contraction of oviductal smooth muscle by Arbab, Farinaz, Goldsby, Jennifer, Matijevic-Aleksic, Nena, Huang, Gangxiong, Ruan, Ke-He, Huang, Jaou-Chen

“…BACKGROUND: It was recently discovered that prostacyclin constituted 40–50% of prostaglandins (PG) produced by minced human oviduct. It is well established…”
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Abstract 1843: Combination therapy targeting Rb/Wee1 kinase pathways for rhabdomyosarcoma treatment by Kiany, Simin, Huang, Gangxiong, Justice, Melanie, Keyomarsi, Khandan, Kleinerman, Eugenie

“…Abstract Introduction Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma. New therapeutic strategies are needed particularly for high-risk…”
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CAPER‐α alternative splicing regulates the expression of vascular endothelial growth factor 165 in Ewing sarcoma cells by Huang, Gangxiong, Zhou, Zhichao, Wang, Hua, Kleinerman, Eugenie S.

“…Abstract BACKGROUND: TC‐71 Ewing sarcoma cells overexpress vascular endothelial growth factor (VEGF) with a shift from the 189 to the 165 isoform. METHODS: The…”
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Repeat Infusion of CD19-Specific Chimeric Antigen Receptor T-Cell Could Improve the Efficacy with Consistent Safety in Relapsed/Refractory Diffuse Large B-Cell Lymphoma by Hu, Jianda, Yang, Ting, Yang, Xiaozhu, Xian, Na, Chen, Yanxin, Jiang, Peifang, Huang, Gangxiong

“…Background Patients with relapse and/or chemo-refractory (R/R) diffuse large B cell lymphoma (DLBCL) are often fail to conventional therapy and suffer dismal…”
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Superior Outcomes in Relapsed/Refractory Childhood B-ALL Than Adult Patients with CD19 CAR-T Cell Therapy: A Single-Center Pilot Prospective Study of 23 Patients by Li, Tingting, Luo, Luting, Ren, Jinhua, Luo, Xiaofeng, Zheng, Zhihong, Zheng, Hao, Chen, Zhizhe, Huang, Gangxiong, Yang, Ting, Hu, Jianda

“…Objective: CD19 CAR-T cell therapy has emerged as a powerful immunotherapy for relapsed/refractory (R/R) B-ALL. The purpose of this study is to compare the…”
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Participation of the Fas/FasL signaling pathway and the lung microenvironment in the development of osteosarcoma lung metastases by Huang, Gangxiong, Nishimoto, Kazumasa, Yang, Yuanzheng, Kleinerman, Eugenie S

“…The lungs are the most common site for the metastatic spread of osteosarcoma. Success in using chemotherapy to improve overall survival has reached a plateau…”
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CAPER-α alternative splicing regulates the expression of VEGF165 in Ewing’s sarcoma cells by Huang, Gangxiong, Zhou, Zhichao, Wang, Hua, Kleinerman, Eugenie S.

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Targeted reduction of the EGFR protein, but not inhibition of its kinase activity, induces mitophagy and death of cancer cells through activation of mTORC2 and Akt by Katreddy, Rajasekhara Reddy, Bollu, Lakshmi Reddy, Su, Fei, Xian, Na, Srivastava, Shivangi, Thomas, Rintu, Dai, Yubing, Wu, Bing, Xu, Yunlu, Rea, Michael A., Briggs, James M., Zhang, Qingyuan, Lu, Xiongbin, Huang, Gangxiong, Weihua, Zhang

“…The oncogenic epidermal growth factor receptor (EGFR) is commonly overexpressed in solid cancers. The tyrosine kinase activity of EGFR has been a major…”
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Promoting NK cell trafficking to improve therapeutic effect of NK cell therapy on osteosarcoma by Yang, Yuanzheng, Gordon, Nancy, Kleinerman, Eugenie S, Huang, Gangxiong

“…BackgroundDespite the ability of NK cells to kill cancer cells, NK cell–based immunotherapy has resulted in limited clinical benefit. This is largely due to…”
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Structural and functional characterization of the first intracellular loop of human thromboxane A2 receptor by Geng, Linda, Wu, Jiaxin, So, Shui-Ping, Huang, Gangxiong, Ruan, Ke-He

“…The conformation of a constrained peptide mimicking the putative first intracellular domain (iLP1) of thromboxane A(2) receptor (TP) was determined by (1)H 2D…”
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