Search Results - "Huang, Chunshuai"

Cas12a-assisted precise targeted cloning using in vivo Cre-lox recombination by Enghiad, Behnam, Huang, Chunshuai, Guo, Fang, Jiang, Guangde, Wang, Bin, Tabatabaei, S. Kasra, Martin, Teresa A., Zhao, Huimin

“…Direct cloning represents the most efficient strategy to access the vast number of uncharacterized natural product biosynthetic gene clusters (BGCs) for the…”
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Heterologous Expression of Fluostatin Gene Cluster Leads to a Bioactive Heterodimer by Yang, Chunfang, Huang, Chunshuai, Zhang, Wenjun, Zhu, Yiguang, Zhang, Changsheng

“…The biosynthesis gene cluster (fls) for atypical angucycline fluostatins was identified from the marine derived Micromonospora rosaria SCSIO N160 and was…”
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Genome mining unveils a class of ribosomal peptides with two amino termini by Ren, Hengqian, Dommaraju, Shravan R., Huang, Chunshuai, Cui, Haiyang, Pan, Yuwei, Nesic, Marko, Zhu, Lingyang, Sarlah, David, Mitchell, Douglas A., Zhao, Huimin

“…The era of inexpensive genome sequencing and improved bioinformatics tools has reenergized the study of natural products, including the ribosomally synthesized…”
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Metabolic engineering of oleaginous yeast Rhodotorula toruloides for overproduction of triacetic acid lactone by Cao, Mingfeng, Tran, Vinh G., Qin, Jiansong, Olson, Andrew, Mishra, Shekhar, Schultz, John C., Huang, Chunshuai, Xie, Dongming, Zhao, Huimin

“…The plant‐sourced polyketide triacetic acid lactone (TAL) has been recognized as a promising platform chemical for the biorefinery industry. However, its…”
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Biochemical and structural insights of multifunctional flavin-dependent monooxygenase FlsO1-catalyzed unexpected xanthone formation by Yang, Chunfang, Zhang, Liping, Zhang, Wenjun, Huang, Chunshuai, Zhu, Yiguang, Jiang, Xiaodong, Liu, Wei, Zhao, Mengran, De, Bidhan Chandra, Zhang, Changsheng

“…Xanthone-containing natural products display diverse pharmacological properties. The biosynthetic mechanisms of the xanthone formation have not been well…”
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Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines by Huang, Chunshuai, Yang, Chunfang, Zhang, Wenjun, Zhang, Liping, De, Bidhan Chandra, Zhu, Yiguang, Jiang, Xiaodong, Fang, Chunyan, Zhang, Qingbo, Yuan, Cheng-Shan, Liu, Hung-wen, Zhang, Changsheng

“…Lomaiviticin A and difluostatin A are benzofluorene-containing aromatic polyketides in the atypical angucycline family. Although these dimeric compounds are…”
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Albumycin, a new isoindolequinone from Streptomyces albus J1074 harboring the fluostatin biosynthetic gene cluster by Huang, Chunshuai, Yang, Chunfang, Zhang, Wenjun, Zhu, Yiguang, Ma, Liang, Fang, Zhuangjie, Zhang, Changsheng

“…Heterologous expression of the fluostatin biosynthetic gene cluster from the marine-derived Micromonospora rosaria SCSIO N160 in Streptomyces albus J1074 led…”
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Flavin-enabled reductive and oxidative epoxide ring opening reactions by De, Bidhan Chandra, Zhang, Wenjun, Yang, Chunfang, Mándi, Attila, Huang, Chunshuai, Zhang, Liping, Liu, Wei, Ruszczycky, Mark W., Zhu, Yiguang, Ma, Ming, Bashiri, Ghader, Kurtán, Tibor, Liu, Hung-wen, Zhang, Changsheng

“…Epoxide ring opening reactions are common and important in both biological processes and synthetic applications and can be catalyzed in a non-redox manner by…”
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Discovery of Stealthin Derivatives and Implication of the Amidotransferase FlsN3 in the Biosynthesis of Nitrogen-Containing Fluostatins by Huang, Chunshuai, Yang, Chunfang, Fang, Zhuangjie, Zhang, Liping, Zhang, Wenjun, Zhu, Yiguang, Zhang, Changsheng

“…Diazobenzofluorene-containing atypical angucyclines exhibit promising biological activities. Here we report the inactivation of an amidotransferase-encoding…”
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Marine Bacterial Aromatic Polyketides From Host-Dependent Heterologous Expression and Fungal Mode of Cyclization by Huang, Chunshuai, Yang, Chunfang, Zhu, Yiguang, Zhang, Wenjun, Yuan, Chengshan, Zhang, Changsheng

“…The structure diversity of type II polyketide synthases-derived bacterial aromatic polyketides is often enhanced by enzyme controlled or spontaneous…”
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Unraveling the iterative type I polyketide synthases hidden in Streptomyces by Wang, Bin, Guo, Fang, Huang, Chunshuai, Zhao, Huimin

“…Type I polyketide synthases (T1PKSs) are one of the most extensively studied PKSs, which can act either iteratively or via an assembly-line mechanism. Domains…”
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Ene Reductase Enabled Intramolecular β‐C−H Functionalization of Substituted Cyclohexanones for Efficient Synthesis of Bridged Bicyclic Nitrogen Scaffolds by Jiang, Guangde, Huang, Chunshuai, Harrison, Wesley, Li, Hongxiang, Zhou, Megan, Zhao, Huimin

“…Herein we report that ene reductases (EREDs) can facilitate an unprecedented intramolecular β‐C−H functionalization reaction for the synthesis of bridged…”
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Inactivation of Flavoenzyme-Encoding Gene flsO1 in Fluostatin Biosynthesis Leads to Diversified Angucyclinone Derivatives by Yang, Chunfang, Huang, Chunshuai, Fang, Chunyan, Zhang, Liping, Chen, Siqiang, Zhang, Qingbo, Zhang, Changsheng, Zhang, Wenjun

“…Inactivation of the flavoenzyme-encoding gene flsO1 in fluostatin biosynthesis led to the isolation of four new angucyclinone derivatives (11, 12, 14, and 15),…”
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Ene Reductase Enabled Intramolecular β–C–H Functionalization of Substituted Cyclohexanones for Efficient Synthesis of Bridged Bicyclic Nitrogen Scaffolds by Jiang, Guangde, Huang, Chunshuai, Harrison, Wesley, Li, Hongxiang, Zhou, Megan, Zhao, Huimin

“…Abstract Herein we report that ene reductases (EREDs) can facilitate an unprecedented intramolecular β‐C−H functionalization reaction for the synthesis of…”
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Ene Reductase Enabled Intramolecular β‐C−H Functionalization of Substituted Cyclohexanones for Efficient Synthesis of Bridged Bicyclic Nitrogen Scaffolds by Jiang, Guangde, Huang, Chunshuai, Harrison, Wesley, Li, Hongxiang, Zhou, Megan, Zhao, Huimin

“…Herein we report that ene reductases (EREDs) can facilitate an unprecedented intramolecular β‐C−H functionalization reaction for the synthesis of bridged…”
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Defensive Specialized Metabolites from the Latex of Euphorbia jolkinii by Luo, Shihong, Huang, Chunshuai, Hua, Juan, Jing, Shuxi, Teng, Linlin, Tang, Ting, Liu, Yan, Li, Shenghong

“…Plant latex is sequestered in laticiferous structures and exuded immediately from damaged plant tissues. The primary function of plant latex is related to…”
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Discovery of an Unexpected 1,4-Oxazepine-Linked seco -Fluostatin Heterodimer by Inactivation of the Oxidoreductase-Encoding Gene flsP by Huang, Chunshuai, Yang, Chunfang, Zhang, Wenjun, Zhang, Liping, Zhu, Yiguang, Zhang, Changsheng

“…Fluostatins belong to the atypical angucyclinone aromatic polyketides featuring a distinctive tetracyclic benzo[ ]fluorene skeleton. To understand the…”
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Non-modular Fatty Acid Synthases Yield Unique Acylation in Ribosomal Peptides by Ren, Hengqian, Huang, Chunshuai, Pan, Yuwei, Dommaraju, Shravan R., Cui, Haiyang, Li, Maolin, Gadgil, Mayuresh G., Mitchell, Douglas A., Zhao, Huimin

“…Recent efforts in genome mining of ribosomally synthesized and post-translationally modified peptides (RiPPs) have expanded the diversity of post-translational…”
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Non-modular fatty acid synthases yield distinct N-terminal acylation in ribosomal peptides by Ren, Hengqian, Huang, Chunshuai, Pan, Yuwei, Dommaraju, Shravan R., Cui, Haiyang, Li, Maolin, Gadgil, Mayuresh G., Mitchell, Douglas A., Zhao, Huimin

“…Recent efforts in genome mining of ribosomally synthesized and post-translationally modified peptides (RiPPs) have expanded the diversity of post-translational…”
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Investigation of the Biosynthetic Mechanism of Bipentaromycin Featuring an Unprecedented Cyclic Head-to-Tail Dimeric Scaffold by Huang, Chunshuai, Cui, Haiyang, Ren, Hengqian, Zhao, Huimin

“…Bipentaromycins are heterodimeric aromatic polyketides featuring two distinctive 5/6/6/6/5 pentacyclic ring systems and exhibit antibacterial activities…”
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