Search Results - "Huan, Xia‐Juan"

Increased PARP1‐DNA binding due to autoPARylation inhibition of PARP1 on DNA rather than PARP1‐DNA trapping is correlated with PARP1 inhibitor's cytotoxicity by Chen, Hua‐Dong, Chen, Chuan‐Huizi, Wang, Yu‐Ting, Guo, Ne, Tian, Yu‐Nan, Huan, Xia‐Juan, Song, Shan‐Shan, He, Jin‐Xue, Miao, Ze‐Hong

“…PARP1 inhibitors (PARPis) are used clinically during cancer therapy and are thought to exert their cytotoxicity through PARP1 polymerase inhibition and…”
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Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance by Wang, Li‐Min, Wang, Pingyuan, Chen, Xiao‐Min, Yang, Hui, Song, Shan‐Shan, Song, Zilan, Jia, Li, Chen, Hua‐Dong, Bao, Xu‐Bin, Guo, Ne, Huan, Xia‐Juan, Xi, Yong, Shen, Yan‐Yan, Yang, Xin‐Ying, Su, Yi, Sun, Yi‐Ming, Gao, Ying‐Lei, Chen, Yi, Ding, Jian, Lang, Jing‐Yu, Miao, Ze‐Hong, Zhang, Ao, He, Jin‐Xue

“…Poly‐ADP‐ribose polymerase (PARP) inhibitors (PARPi) have shown great promise for treating BRCA‐deficient tumors. However, over 40% of BRCA‐deficient patients…”
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Glycogen synthase kinase 3β inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer by Zhang, Ning, Tian, Yu-Nan, Zhou, Li-Na, Li, Meng-Zhu, Chen, Hua-Dong, Song, Shan-Shan, Huan, Xia-Juan, Bao, Xu-Bin, Zhang, Ao, Miao, Ze-Hong, He, Jin-Xue

“…Monotherapy with poly ADP-ribose polymerase (PARP) inhibitors results in a limited objective response rate (≤60% in most cases) in patients with homologous…”
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SOMCL-19-133, a novel, selective, and orally available inhibitor of NEDD8-activating enzyme (NAE) for cancer therapy by Zhou, Li-Na, Xiong, Chaodong, Cheng, Yong-Jun, Song, Shan-Shan, Bao, Xu-Bin, Huan, Xia-Juan, Wang, Tong-Yan, Zhang, Ao, Miao, Ze-Hong, He, Jin-Xue

“…Inhibition of the NEDD8-activating enzyme (NAE), the key E1 enzyme in the neddylation cascade, has been considered an attractive anticancer strategy with the…”
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Cytotoxic Nitrogenous Terpenoids from Two South China Sea Nudibranchs Phyllidiella pustulosa , Phyllidia coelestis , and Their Sponge-Prey Acanthella cavernosa by Wu, Qihao, Chen, Wen-Ting, Li, Song-Wei, Ye, Jian-Yu, Huan, Xia-Juan, Gavagnin, Margherita, Yao, Li-Gong, Wang, Hong, Miao, Ze-Hong, Li, Xu-Wen, Guo, Yue-Wei

“…A detailed chemical investigation of two South China Sea nudibranchs and , as well as their possible sponge-prey , led to the isolation of one new nitrogenous…”
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Polyoxygenated Cembranoids from Soft Coral Lobophytum Crassum and Their Anti‐tumoral Activities by Yin, Fang‐Zhou, Huan, Xia‐Juan, Mudianta, I. Wayan, Miao, Ze‐Hong, Wang, Hong, Guo, Yue‐Wei, Li, Xu‐Wen

“…Main observation and conclusion Four new cembranoids, 6‐oxo‐cembrene‐A (1), lobocrassins G—H (2—3), and 14‐epi‐lobophytolide B (4), along with eight known…”
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Chemical constituents from the South China sea soft coral Sinularia humilis by Li, Jie, Huan, Xia-Juan, Wu, Meng-Jun, Chen, Zi-Hui, Chen, Bao, Miao, Ze-Hong, Guo, Yue-Wei, Li, Xu-Wen

“…A new diterpenoid with an unusual capnosane skeleton, sinuhumilol A (1), alone with twelve known diverse compounds (2-13), were isolated from the South China…”
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Inhibition of the BET family reduces its new target gene IDO1 expression and the production of l-kynurenine by Tian, Chang-Qing, Chen, Lin, Chen, Hua-Dong, Huan, Xia-Juan, Hu, Jian-Ping, Shen, Jing-Kang, Xiong, Bing, Wang, Ying-Qing, Miao, Ze-Hong

“…The bromodomain and extra terminal domain (BET) family members, including BRD2, BRD3, and BRD4, act as epigenetic readers to regulate gene expression…”
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Uncommon Bis‐quinolizidine Alkaloids from the Hainan Sponge Neopetrosia chaliniformis by Chen, Bao, Huan, Xia‐Juan, Miao, Ze‐Hong, Voogd, Nicole J., Gu, Yu‐Cheng, Wang, Chang‐Yun, Guo, Yue‐Wei, Li, Xu‐Wen

“…Main observation and conclusion Two new bis‐quinolizidine alkaloids, neopetrosiasins A (1) and B (2), possessing cis‐ and trans‐quinolizidine nuclei, one known…”
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A new bis-γ-pyrone polypropionate of onchidiol family from marine pulmonate mollusk Onchidium sp by Li, Song-Wei, Cui, Wan-Xiang, Huan, Xia-Juan, Gavagnin, Margherita, Mollo, Ernesto, Miao, Ze-Hong, Yao, Li-Gong, Li, Xu-Wen, Guo, Yue-Wei

“…A new bis-γ-pyrone polypropionate, 4,16-di-epi-onchidiol (1), along with three known related compounds (2-4) were isolated from the marine pulmonate mollusk…”
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A new BET inhibitor, 171, inhibits tumor growth through cell proliferation inhibition more than apoptosis induction by Damaneh, Mohammadali Soleimani, Hu, Jian-Ping, Huan, Xia-Juan, Song, Shan-Shan, Tian, Chang-Qing, Chen, Dan-Qi, Meng, Tao, Chen, Yue-Lei, Shen, Jing-Kang, Xiong, Bing, Miao, Ze-Hong, Wang, Ying-Qing

“…Summary The bromodomain and extra-terminal domain (BET) family of proteins, especially bromodomain-containing protein 4 (BRD4), has emerged as exciting…”
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Lagerindicine, a New Pyrrole Alkaloid Isolated from the Flowers of Lagerstroemia indica Linnaeus by Chen, Yi, Li, Song-Wei, Yin, Fang-Zhou, Yang, Min, Huan, Xia-Juan, Miao, Ze-Hong, Wang, Xiao-Ming, Guo, Yue-Wei

“…A phytochemical investigation of the EtOH extract of the flowers of Lagerstroemia indica L. led to the isolation and characterization of a new pyrrole…”
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Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy by Zhang, Qian, Wu, Qian, Huan, Xia-Juan, Song, Shan-Shan, Bao, Xu-Bin, Miao, Ze-Hong, Wang, Ying-Qing

“…[Display omitted] Agents that inhibit bromodomain and extra-terminal domain (BET) proteins have been actively tested in the clinic as potential anticancer…”
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Loss of VOPP1 Contributes to BET Inhibitor Acquired Resistance in Non-Small Cell Lung Cancer Cells by Sun, Lin, Wu, Qian, Huan, Xia-Juan, Tian, Chang-Qing, Wang, Ying-Qing, Miao, Ze-Hong

“…Inhibitors targeting bromodomain and extraterminal (BET) proteins are promising anticancer drugs. The emergence of drug resistance during treatments will…”
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The combination of methionine adenosyltransferase 2A inhibitor and methyltransferase like 3 inhibitor promotes apoptosis of non-small cell lung cancer cells and produces synergistic anti-tumor activity by Xuan, Yi-Fei, Lu, Shan, Ou, Ying-Jie, Bao, Xu-Bin, Huan, Xia-Juan, Song, Shan-Shan, Miao, Ze-Hong, Wang, Ying-Qing

“…Methionine adenosyltransferase 2 A (MAT2A) mediates the synthesis of methyl donor S-Adenosylmethionine (SAM), providing raw materials for methylation reactions…”
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Identification of 2-substituted pyrrolo[1,2-b]pyridazine derivatives as new PARP-1 inhibitors by Xiang, Hao-Yue, Chen, Jian-Yang, Huan, Xia-Juan, Chen, Yi, Gao, Zhao-bing, Ding, Jian, Miao, Ze-Hong, Yang, Chun-Hao

“…[Display omitted] A library of new 2-substituted pyrrolo[1,2-b]pyridazine derivatives were rapidly assembled and identified as PARP inhibitors…”
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Structure-Based Discovery and Development of a Series of Potent and Selective Bromodomain and Extra-Terminal Protein Inhibitors by Hu, Jianping, Tian, Chang-Qing, Damaneh, Mohammadali Soleimani, Li, Yanlian, Cao, Danyan, Lv, Kaikai, Yu, Ting, Meng, Tao, Chen, Danqi, Wang, Xin, Chen, Lin, Li, Jian, Song, Shan-Shan, Huan, Xia-Juan, Qin, Lihuai, Shen, Jingkang, Wang, Ying-Qing, Miao, Ze-Hong, Xiong, Bing

“…BRD4 has recently emerged as a promising drug target. Therefore, identifying novel inhibitors with distinct properties could enrich their use in anticancer…”
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Erectsterates A and B, a pair of novel highly degraded steroid derivatives from the South China Sea soft coral Sinularia erecta by Liu, Jiao, Wu, Xin, Yang, Min, Gu, Yu-Cheng, Yao, Li-Gong, Huan, Xia-Juan, Miao, Ze-Hong, Luo, Hui, Guo, Yue-Wei

“…[Display omitted] •Two novel steroidal derivatives were isolated from the South China Sea soft coral Sinularia erecta.•Such kind of ring B-degraded steroids…”
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Proteasome inhibitors reduce CD73 expression partly via decreasing p-ERK in NSCLC cells by Su, Ai-Ling, Tian, Chang-Qing, Ou, Ying-Jie, Bao, Xu-Bin, Huan, Xia-Juan, Miao, Ze-Hong, Wang, Ying-Qing

“…Ecto-5'-nucleotidase (CD73), encoded by the NT5E gene, mediates tumor immunosuppression and has been targeted for the development of new anticancer drugs…”
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Triptolide Induces Cell Killing in Multidrug-Resistant Tumor Cells via CDK7/RPB1 Rather than XPB or p44 by Yi, Jun-Mei, Huan, Xia-Juan, Song, Shan-Shan, Zhou, Hu, Wang, Ying-Qing, Miao, Ze-Hong

“…Multidrug resistance (MDR) is a major cause of tumor treatment failure; therefore, drugs that can avoid this outcome are urgently needed. We studied…”
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