Search Results - "Huailing Zhong"

Escitalopram, an antidepressant with an allosteric effect at the serotonin transporter—a review of current understanding of its mechanism of action by Zhong, Huailing, Haddjeri, Nasser, Sánchez, Connie

“…Rationale Escitalopram is a widely used antidepressant for the treatment of patients with major depression. It is the pure S-enantiomer of racemic citalopram…”
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Discovery of 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): A Novel Multimodal Compound for the Treatment of Major Depressive Disorder by Bang-Andersen, Benny, Ruhland, Thomas, Jørgensen, Morten, Smith, Garrick, Frederiksen, Kristen, Jensen, Klaus Gjervig, Zhong, Huailing, Nielsen, Søren Møller, Hogg, Sandra, Mørk, Arne, Stensbøl, Tine Bryan

“…The synthesis and structure−activity relationship of a novel series of compounds with combined effects on 5-HT3A and 5-HT1A receptors and on the serotonin…”
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Small-molecule antagonists of melanopsin-mediated phototransduction by Jones, Kenneth A, Hatori, Megumi, Mure, Ludovic S, Bramley, Jayne R, Artymyshyn, Roman, Hong, Sang-Phyo, Marzabadi, Mohammad, Zhong, Huailing, Sprouse, Jeffrey, Zhu, Quansheng, Hartwick, Andrew T E, Sollars, Patricia J, Pickard, Gary E, Panda, Satchidananda

“…Opsinamides are nonretinoid inhibitors that compete with 9- cis -retinal for binding to melanopsin Opn4 without affecting rod- and cone-mediated visual…”
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Regulator of G protein signaling proteins: novel multifunctional drug targets by Zhong, H, Neubig, R R

“…G protein-coupled receptors (GPCRs) play a major role in signal transduction and are targets of many therapeutic drugs. The regulator of G protein signaling…”
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Anxiolytic- and Antidepressant-like Profiles of the Galanin-3 Receptor ($Gal_3$) Antagonists SNAP 37889 and SNAP 398299 by Chad J. Swanson, Thomas P. Blackburn, Xuexiang Zhang, Zheng, Kang, Xu, Zhi-Qing David, Hökfelt, Tomas, Toni D. Wolinsky, Michael J. Konkel, Heidi Chen, Huailing Zhong, Mary W. Walker, Craig, Douglas A., Christophe P. G. Gerald, Branchek, Theresa A.

“…The neuropeptide galanin mediates its effects through the receptor subtypes$Gal_1$,$Gal_2$, and$Gal_3$and has been implicated in anxiety-and depression-related…”
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An allosteric binding site at the human serotonin transporter mediates the inhibition of escitalopram by R-citalopram: Kinetic binding studies with the ALI/VFL–SI/TT mutant by Zhong, Huailing, Hansen, Kasper B., Boyle, Noel J., Han, Kiho, Muske, Galina, Huang, Xinyan, Egebjerg, Jan, Sánchez, Connie

“…The human serotonin transporter (hSERT) has primary and allosteric binding sites for escitalopram and R-citalopram. Previous studies have established that the…”
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Cocaine induction of dopamine transporter trafficking to the plasma membrane by Little, Karley Y, Elmer, Lawrence W, Zhong, Huailing, Scheys, Joshua O, Zhang, Lian

“…Several previous human postmortem experiments have detected an increase in striatal [(3)H]WIN 35428 binding to the dopamine transporter (DAT) in chronic…”
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The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity by Walker, Mary W, Wolinsky, Toni D, Jubian, Vrej, Chandrasena, Gamini, Zhong, Huailing, Huang, Xinyan, Miller, Silke, Hegde, Laxminarayan G, Marsteller, Douglas A, Marzabadi, Mohammad R, Papp, Mariusz, Overstreet, David H, Gerald, Christophe P G, Craig, Douglas A

“…Neuropeptide Y (NPY) regulates physiological processes via receptor subtypes (Y(1), Y(2), Y(4), Y(5), and y(6)). The Y(5) receptor is well known for its role…”
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A Spatial Focusing Model for G Protein Signals by Zhong, Huailing, Wade, Susan M., Woolf, Peter J., Linderman, Jennifer J., Traynor, John R., Neubig, Richard R.

“…Regulators of G protein signaling (RGS) are GTPase-accelerating proteins (GAPs), which can inhibit heterotrimeric G protein pathways. In this study, we provide…”
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Label-free pharmacological profiling based on dynamic mass redistribution for characterization and authentication of hazardous natural products by Song, Hui-Peng, Wang, Hong, Zhao, Xiaoai, He, Ling, Zhong, Huailing, Wu, Si-Qi, Li, Ping, Yang, Hua

“…[Display omitted] •Dynamic mass redistribution (DMR) profiling was proposed to characterize toxic herbs.•Qualitative DMR profiling has obvious advantages over…”
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A label-free screening approach targeted protease-activated receptor 1 based on dynamic mass redistribution in living cells by Tang, Weiwei, Huang, Bixia, Wang, Jiancheng, An, Lin, Zhong, Huailing, Yang, Hua, Li, Ping, Chen, Jun

“…Protease-activated receptor 1 (PAR-1) antagonists strongly inhibit thrombin-induced platelet aggregation and are proved to be effective as anti-thrombotic…”
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Consideration of allosterism and interacting proteins in the physiological functions of the serotonin transporter by Zhong, Huailing, Sánchez, Connie, Caron, Marc G.

“…The serotonin transporter (SERT) functions to transport serotonin (5-HT) from the extracellular space into neurons to maintain homeostatic control of 5-HT. It…”
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A label-free screening approach targeted protease-activated receptor 1 based on dynamic mass redistribution in living cellsElectronic supplementary information (ESI) available. See DOI: 10.1039/c7ra07927c by Tang, Weiwei, Huang, Bixia, Wang, Jiancheng, An, Lin, Zhong, Huailing, Yang, Hua, Li, Ping, Chen, Jun

“…Protease-activated receptor 1 (PAR-1) antagonists strongly inhibit thrombin-induced platelet aggregation and are proved to be effective as anti-thrombotic…”
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Endogenous RGS Proteins and Gα Subtypes Differentially Control Muscarinic and Adenosine-Mediated Chronotropic Effects by Fu, Ying, Huang, Xinyan, Zhong, Huailing, Mortensen, Richard M, D’Alecy, Louis G, Neubig, Richard R

“…Cardiac automaticity is controlled by G protein–coupled receptors, such as adrenergic, muscarinic, and adenosine receptors. The strength and duration of G…”
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RGS-insensitive G-protein mutations to study the role of endogenous RGS proteins by Fu, Ying, Zhong, Huailing, Nanamori, Masakatsu, Mortensen, Richard M, Huang, Xinyan, Lan, Kengli, Neubig, Richard R

“…Regulator of G-protein signaling (RGS) proteins are very active GTPase-accelerating proteins (GAPs) in vitro and are expected to reduce signaling by G-protein…”
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Endogenous RGS proteins and ga subtypes differentially control muscarinic and adenosine-mediated chronotropic effects by YING FU, XINYAN HUANG, HUAILING ZHONG, MORTENSEN, Richard M, D'ALECY, Louis G, NEUBIG, Richard R

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Endogenous RGS protein action modulates mu-opioid signaling through Galphao. Effects on adenylyl cyclase, extracellular signal-regulated kinases, and intracellular calcium pathways by Clark, Mary J, Harrison, Charlotte, Zhong, Huailing, Neubig, Richard R, Traynor, John R

“…RGS (regulators of G protein signaling) proteins are GTPase-activating proteins for the Galpha subunits of heterotrimeric G proteins and act to regulate…”
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Endogenous RGS Protein Action Modulates μ-Opioid Signaling through Gαo by Mary J. Clark, Charlotte Harrison, Huailing Zhong, Richard R. Neubig, John R. Traynor

“…RGS ( r egulators of G protein s ignaling) proteins are GTPase-activating proteins for the Gα subunits of heterotrimeric G proteins and act to regulate…”
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Endogenous RGS Protein Action Modulates μ-Opioid Signaling through Gαo by Clark, Mary J., Harrison, Charlotte, Zhong, Huailing, Neubig, Richard R., Traynor, John R.

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Structure-based design, synthesis, and activity of peptide inhibitors of RGS4 GAP activity by Jin, Yafei, Zhong, Huailing, Omnaas, John R, Neubig, Richard R, Mosberg, Henry I

“…One of the principal roles of the multifunctional regulator of G-protein signaling (RGS) proteins is to terminate G-protein-coupled receptor (GPCR) signaling…”
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