Low‐intensity, long‐wavelength red light slows the progression of myopia in children: an Eastern China‐based cohort

Low‐intensity, long‐wavelength red light slows the progression of myopia in children: an Eastern China‐based cohort

Purpose To determine the effect of low‐intensity, long‐wavelength red light therapy (LLRT) on the inhibition of myopia progression in children. Methods A retrospective study was conducted. One hundred and five myopic children (spherical equivalent refractive error [SER] −3.09 ± 1.74 dioptres [D]; me...

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Bibliographic Details
Published in:Ophthalmic & physiological optics Vol. 42; no. 2; pp. 335 - 344
Main Authors: Zhou, Lei, Xing, Chao, Qiang, Wei, Hua, Chaoqun, Tong, Liyang
Format: Journal Article
Language:English
Published: England Wiley Subscription Services, Inc 01-03-2022
Subjects:
axial length
Axial Length, Eye
Child
Child, Preschool
Children
China - epidemiology
choroid binarization
Disease Progression
Humans
Myopia
Myopia - diagnosis
Myopia - therapy
Phototherapy
red light
Refraction, Ocular
Retrospective Studies
Wavelength
China
wavelength
myopia
choroid binarization
red light
axial length
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Summary:Purpose To determine the effect of low‐intensity, long‐wavelength red light therapy (LLRT) on the inhibition of myopia progression in children. Methods A retrospective study was conducted. One hundred and five myopic children (spherical equivalent refractive error [SER] −3.09 ± 1.74 dioptres [D]; mean age, 9.19 ± 2.40 years) who underwent LLRT treatment (power 0.4 mW, wavelength 635 nm) twice per day for 3 min each session, with at least a 4‐h interval between sessions, and a control group of 56 myopic children (SER −3.04 ± 1.66 D; mean age, 8.62 ± 2.45 years) were evaluated. Both groups wore single‐vision distance spectacles. Each child returned for a follow‐up examination every 3 months after the initial measurements for a total of 9 months. Results At 9 months, the mean SER in the LLRT group was −2.87 ± 1.89 D, significantly greater than that of the control group (−3.57 ± 1.49 D, p < 0.001). Axial length (AL) changes were −0.06 ± 0.19 mm and 0.26 ± 0.15 mm in the LLRT group and control group (p < 0.001), respectively. The subfoveal choroidal thickness changed by 45.32 ± 30.88 μm for children treated with LLRT at the 9‐month examination (p < 0.001). Specifically, a substantial hyperopic shift (0.31 ± 0.24 D and 0.20 ± 0.14 D, respectively, p = 0.02) was found in the 8–14 year olds compared with 4–7 year old children. The decrease in AL in subjects with baseline AL >24 mm was −0.08 ± 0.19 mm, significantly greater than those with a baseline AL ≤24 mm (−0.04 ± 0.18 mm, p = 0.03). Conclusions Repetitive exposure to LLRT therapy was associated with slower myopia progression and reduced axial growth after short durations of treatment. These results require further validation in randomised controlled trials.
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ISSN:0275-5408
1475-1313
DOI:10.1111/opo.12939