Search Results - "Hua, Baolai"

Timely and large dose of clotting factor IX provides better joint wound healing after hemarthrosis in hemophilia B mice by He, Ping, Zhang, Feixu, Zhong, Chen, Li, Min, Zheng, Jing, Hua, Baolai, Sun, Junjiang

“…Bleeding into the joints represents the major morbidity of severe hemophilia and predisposes it to hemophilic arthropathy (HA). In a reproducible hemarthrosis…”
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The endothelial specific isoform of type XVIII collagen correlates to annual bleeding rate in haemophilia patients by Kjeld, Nadja Gad, Hua, Baolai, Karsdal, Morten Asser, Sun, Shu, Manon-Jensen, Tina

“…The medical need in the haemophilic (HF) field to reduce bleeding incidents requires measurement of the annual bleeding rate (ABR) in haemophiliacs. Vascular…”
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Novel Piperazino-Enaminones Decrease Pro-inflammatory Cytokines Following Hemarthrosis in a Hemophilia Mouse Model by Zhong, Chen, Szollosi, Doreen, Sun, Junjiang, Hua, Baolai, Ghoneim, Ola, Bill, Ashley, Zhuang, Yingping, Edafiogho, Ivan

“…Hemarthrosis is the primary cause of hemophiliac arthropathy (HA). Pro-inflammatory cytokines are thought to play an important role in the pathogenesis of HA,…”
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Protein S gene mutation c.946C > T (p.R316C) contributed to ischemic stroke in a man with von Willebrand disease type 3 caused by two novel VWF gene mutations, c.2328delT (p.A778Lfs 23) and c.6521G > T (p.C2174F) by Hua, Baolai, Yan, Xiaobo, He, Bin, Shen, Lianjun, Poon, Man‐Chiu

“…The risk factors for a family with VWD presenting with an ischemic stroke (IS) were explored. FVIII activity (FVIII:C), VWF antigen (VWF:Ag), and protein S…”
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A Translational Study of TNF-Alpha Antagonists as an Adjunctive Therapy for Preventing Hemophilic Arthropathy by Zhang, Feixu, Xu, Mengyang, Yang, Qin, Hua, Baolai, Xia, Binglan, Lin, Zhenyang, Xiao, Xiao, Monahan, Paul E, Sun, Junjiang

“…Repeated intra-articular hemorrhages lead to hemophilic arthropathy in severe hemophilia. Inflammation and pro-inflammatory cytokines (e.g., tumor necrosis…”
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Clinical and Laboratory Features of Acute Porphyria: A Study of 36 Subjects in a Chinese Tertiary Referral Center by Zhou, Zhou, Zhang, Li, Zhu, Huadong, Zhao, Yongqiang, Zhu, Tienan, Hua, Baolai, Yang, Hang, Chen, Qianlong, Yang, Jing, Yu, Xuezhong

“…Porphyria is a group of eight metabolic disorders characterized by defects in heme biosynthesis. The presentation of porphyria is highly variable, and the…”
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Normal ranges and genetic variants of antithrombin, protein C and protein S in the general Chinese population. Results of the Chinese Hemostasis Investigation on Natural Anticoagulants Study I Group by Zhu, Tienan, Ding, Qiulan, Bai, Xia, Wang, Xiaoyan, Kaguelidou, Florentia, Alberti, Corinne, Wei, Xuqian, Hua, Baolai, Yang, Renchi, Wang, Xuefeng, Wang, Zhaoyue, Ruan, Changgeng, Schlegel, Nicole, Zhao, Yongqiang

“…Inherited deficiency of antithrombin, protein C and protein S, three important, naturally occurring coagulation inhibitors, might play a major role in the…”
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α1-antitrypsin Pittsburgh in a family with bleeding tendency by BAOLAI HUA, LIANKAI FAN, YAN LIANG, YONGQIANG ZHAO, TUDDENHAM, Edward G. D

“…We describe a 16-year-old girl and her 41-year-old father who both had a bleeding tendency, dramatic prolongation of all standard clotting assays, undetectable…”
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A Novel Mutation (G2172→C) in the Factor V Gene in a Chinese Family with Hereditary Activated Protein C Resistance by Cai, Huacong, Hua, Baolai, Fan, Liankai, Wang, Qian, Wang, Shujie, Zhao, Yongqiang

“…Abstract Background Activated protein C resistance (APC-R) was a major risk factor for venous thromboembolism(VTE) in Caucasians, and at least 90% of APC-R…”
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Association of interleukin-1 gene cluster polymorphisms with ischemic stroke in a Chinese population by Lai Jiangtao, Zhou Dongchen, Xia Shudong, Shang Yunpeng, Zhu Jianhua, Pan Jiaqi, Hua Baolai, Zhu Yicheng, Cui Liying

“…Background and Aims: Chronic inflammatory process plays an important role in atherothrombosis. Interleukin-1 (IL-1) is one of the key modulators of the…”
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Anti-inflammatory effect of a novel piperazino-enaminone delivered by liposomes in a mouse model of hemophilic arthropathy by Zhong, Chen, Zong, Xiaoying, Hua, Baolai, Sun, Junjiang

“…[Display omitted] Hemophilic arthropathy (HA) is a condition caused by recurrent intra-articular bleeding in patients with hemophilia. Pro-inflammatory…”
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Activated factor X delivered by adeno-associated virus significantly inhibited bleeding and alleviated hemophilic synovitis in hemophilic mice by Zhang, Feixu, Zhou, Xinyue, Hua, Baolai, He, Xinyi, Li, Zhanao, Xiao, Xiao, Wu, Xia

“…In hemophilia, deficiency of factor VIII or IX prevents the activation of the common coagulation pathway, and inhibits the conversion of FX to activated FXa,…”
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COVID-19 Vaccine Acceptance/Hesitancy and Influence on Infection in Patients with Multiple Myeloma: A National-Wide Multicenter Survey in China by He, Huiwen, Li, Ziping, Liu, Shuangjiao, Chen, Wenming, Sun, Wanling, Hua, Baolai, Li, Yongzhe, Zhuang, Junling

“…Background Patients with multiple myeloma (MM) are immunocompromised due to impaired humoral and cellular immunity in addition to immunosuppressive therapy…”
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Multiple cycles of recombinant human thrombopoietin therapy in a patient with chronic refractory idiopathic thrombocytopenic purpura by Hua, Baolai, Zou, Nong, Wang, Shujie, Zhu, Tienan, Zhao, Yongqiang

“…We describe a 41-year-old woman with chronic idiopathic thrombocytopenic purpura who received recombinant human thrombopoietin (rhTPO) therapy. rhTPO was…”
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P-393 COVID-19 vaccine acceptance/hesitancy and influence on infection in patients with multiple myeloma: a national-wide multicenter survey in China by He, Huiwen, Li, Ziping, Liu, Shuangjiao, Chen, Wenming, Sun, Wanling, Hua, Baolai, Li, Yongzhe, Zhuang, Junling

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Gene Delivery of Activated Factor VII Using Alternative Adeno-Associated Virus Serotype Improves Hemostasis in Hemophiliac Mice with FVIII Inhibitors and Adeno-Associated Virus Neutralizing Antibodies by Sun, Junjiang, Hua, Baolai, Chen, Xiaojing, Samulski, Richard J, Li, Chengwen

“…While therapeutic expression of coagulation factors from adeno-associated virus (AAV) vectors has been successfully achieved in patients with hemophilia,…”
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Abnormal joint and bone wound healing in hemophilia mice is improved by extending factor IX activity after hemarthrosis by Sun, Junjiang, Hua, Baolai, Livingston, Eric W., Taves, Sarah, Johansen, Peter B., Hoffman, Maureane, Ezban, Mirella, Monroe, Dougald M., Bateman, Ted A., Monahan, Paul E.

“…Wound healing requires interactions between coagulation, inflammation, angiogenesis, cellular migration, and proliferation. Healing in dermal wounds of…”
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Low-dose tertiary prophylactic therapy reduces total number of bleeds and improves the ability to perform activities of daily living in adults with severe haemophilia A: a single-centre experience from Beijing by Hua, Baolai, Lian, Xiaoyun, Li, Kuixing, Lee, Adrienne, Poon, Man-Chiu, Zhao, Yongqiang

“…Full-dose prophylaxis treatment for persons with haemophilia is not affordable in China due to its economic constraints, particularly in adults requiring…”
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Protein S gene mutation c. 946C  > T (p. R316C ) contributed to ischemic stroke in a man with von Willebrand disease type 3 caused by two novel VWF gene mutations, c. 2328delT (p. A778Lfs 23) and c. 6521G  > T (p. C2174F ) by Hua, Baolai, Yan, Xiaobo, He, Bin, Shen, Lianjun, Poon, Man‐Chiu

“…The risk factors for a family with VWD presenting with an ischemic stroke (IS) were explored. FVIII activity (FVIII:C), VWF antigen (VWF:Ag), and protein S…”
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Reversible MRI findings in a case of acute intermittent porphyria with a novel mutation in the porphobilinogen deaminase gene by Yang, Jing, Yang, Hang, Chen, Qianlong, Hua, Baolai, Zhu, Tienan, Zhao, Yongqiang, Yu, Xuezhong, Zhu, Huadong, Zhou, Zhou

“…Acute intermittent porphyria (AIP) is an autosomal dominant disorder caused by a partial deficiency of porphobilinogen deaminase (PBGD), the third enzyme in…”
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