Search Results - "Hu Junbo"
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1
IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation
Published in Nature communications (15-06-2021)“…Extracellular cytokines are enriched in the tumor microenvironment and regulate various important properties of cancers, including autophagy. However, the…”
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2
Robust whole slide image analysis for cervical cancer screening using deep learning
Published in Nature communications (24-09-2021)“…Computer-assisted diagnosis is key for scaling up cervical cancer screening. However, current recognition algorithms perform poorly on whole slide image (WSI)…”
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3
M2 Macrophage-Derived Exosomes Promote Cell Migration and Invasion in Colon Cancer
Published in Cancer research (Chicago, Ill.) (01-01-2019)“…: Clinical and experimental evidence has shown that tumor-associated macrophages promote cancer initiation and progression. However, the macrophage-derived…”
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4
Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS
Published in Cell (27-06-2019)“…RLR-mediated type I IFN production plays a pivotal role in elevating host immunity for viral clearance and cancer immune surveillance. Here, we report that…”
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5
The Pathogenesis of Nonalcoholic Fatty Liver Disease: Interplay between Diet, Gut Microbiota, and Genetic Background
Published in Gastroenterology research and practice (01-01-2016)“…Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world, and it comprises a spectrum of hepatic abnormalities from…”
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6
COVID-19 in Wuhan: Sociodemographic characteristics and hospital support measures associated with the immediate psychological impact on healthcare workers
Published in EClinicalMedicine (01-07-2020)“…The outbreak of COVID-19 has laid unprecedented threats and challenges to health workers (HWs) in Wuhan, China. We aimed to assess the sociodemographic…”
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7
SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis
Published in Nature cell biology (01-02-2019)“…The serine/threonine kinase Akt plays a central role in cell proliferation, survival and metabolism, and its hyperactivation is linked to cancer progression…”
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8
Jagged 2 inhibition attenuates hypoxia-induced mitochondrial damage and pulmonary hypertension through Sirtuin 1 signaling
Published in PloS one (26-01-2024)“…Notch pathway has played a significant role in the pathophysiology of pulmonary hypertension (PH). However, the role of Jagged 2 (Jag2), one ligand of Notch,…”
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9
The biodiversity Composition of Microbiome in Ovarian Carcinoma Patients
Published in Scientific reports (08-02-2019)“…Ovarian carcinoma is caused by multiple factors, but its etiology associated with microbes and infection is unknown. Using 16S rRNA high-throughput sequencing…”
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10
A universal optical aptasensor for antibiotics determination based on a new high-efficiency Förster resonance energy transfer pair
Published in Mikrochimica acta (1966) (01-09-2024)“…A novel “turn-on” aptasensor for kanamycin (Kana) detection based on a new Förster resonance energy transfer (FRET) pair is reported. A new organic small…”
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11
MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis
Published in Oncogene (01-02-2020)“…Ovarian cancer selective metastasizes to the omentum contributing to the poor prognosis associated with ovarian cancer. However, the mechanism underlining this…”
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12
TRIB2 functions as novel oncogene in colorectal cancer by blocking cellular senescence through AP4/p21 signaling
Published in Molecular cancer (12-12-2018)“…Cellular senescence is a state of irreversible cell growth arrest and senescence cells permanently lose proliferation potential. Induction of cellular…”
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13
An Optimal Approach for Laparoscopic D3 Lymphadenectomy Plus Complete Mesocolic Excision (D3+CME) for Right-Sided Colon Cancer
Published in Annals of surgical oncology (01-05-2017)“…Background It is common knowledge that high ligation of blood vessels at the D3 level and complete mesocolic excision (CME) are two critical points of right…”
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14
StainNet: A Fast and Robust Stain Normalization Network
Published in Frontiers in medicine (05-11-2021)“…Stain normalization often refers to transferring the color distribution to the target image and has been widely used in biomedical image analysis. The…”
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15
Design and experiment of electromagnetic-hydraulic-rubber integrated vibration isolator
Published in Journal of low frequency noise, vibration, and active control (01-12-2024)“…Low-frequency radiated noise, characterized by a distinctive “acoustic fingerprint” is generated when vibrations from marine machinery propagate through a…”
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16
EZH2-triggered methylation of SMAD3 promotes its activation and tumor metastasis
Published in The Journal of clinical investigation (01-03-2022)“…SMAD3 plays a central role in cancer metastasis, and its hyperactivation is linked to poor cancer outcomes. Thus, it is critical to understand the upstream…”
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17
The autophagy-independent role of BECN1 in colorectal cancer metastasis through regulating STAT3 signaling pathway activation
Published in Cell death & disease (01-05-2020)“…BECN1 is a critical regulator of autophagy, which plays important roles in tumor formation and metastasis. However, the autophagy-independent role of BECN1 and…”
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18
A Frameshift RBM10 Variant Associated With TARP Syndrome
Published in Frontiers in genetics (04-08-2022)“…TARP syndrome is a rare X-linked genetic condition caused by mutations in the RBM10 gene. Primary clinical characteristics of TARP syndrome include Talipes…”
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19
Loss of BRG1 induces CRC cell senescence by regulating p53/p21 pathway
Published in Cell death & disease (01-02-2017)“…Brahma-related gene-1 (BRG1) is the specific ATPase of switch/sucrose nonfermentable chromatin-remodeling complex that is aberrantly expressed or mutated in…”
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20
KDM4B facilitates colorectal cancer growth and glucose metabolism by stimulating TRAF6-mediated AKT activation
Published in Journal of experimental & clinical cancer research (13-01-2020)“…Histone lysine demethylase 4B (KDM4B) has been implicated in various pathological processes and human diseases. Glucose metabolism is the main pattern of…”
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