Search Results - "Hu, Zheping"

High-Throughput Screening for Ligands of the HEPN Domain of Sacsin by Li, Xinlu, Ménade, Marie, Kozlov, Guennadi, Hu, Zheping, Dai, Zheng, McPherson, Peter S, Brais, Bernard, Gehring, Kalle

“…Sacsin is a large protein implicated in the neurodevelopmental and neurodegenerative disease autosomal recessive spastic ataxia of Charlevoix-Saguenay…”
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Multistage Screening Reveals Chameleon Ligands of the Human Farnesyl Pyrophosphate Synthase: Implications to Drug Discovery for Neurodegenerative Diseases by De Schutter, Joris W, Park, Jaeok, Leung, Chun Yuen, Gormley, Patrick, Lin, Yih-Shyan, Hu, Zheping, Berghuis, Albert M, Poirier, Judes, Tsantrizos, Youla S

“…Human farnesyl pyrophosphate synthase (hFPPS) is the gate-keeper of mammalian isoprenoids and the key target of bisphosphonate drugs. Bisphosphonates suffer…”
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