Search Results - "Hu, Zhengqing"

Generation of Cochlear Hair Cells from Sox2 Positive Supporting Cells via DNA Demethylation by Deng, Xin, Hu, Zhengqing

“…Regeneration of auditory hair cells in adult mammals is challenging. It is also difficult to track the sources of regenerated hair cells, especially in vivo…”
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Hearing Recovery Induced by DNA Demethylation in a Chemically Deafened Adult Mouse Model by Deng, Xin, Hu, Zhengqing

“…Functional hair cell regeneration in the adult mammalian inner ear remains challenging. This study aimed to study the function of new hair cells induced by a…”
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Generation of new hair cells by DNA methyltransferase (Dnmt) inhibitor 5-azacytidine in a chemically-deafened mouse model by Deng, Xin, Liu, Zhenjie, Li, Xiaoyang, Zhou, Yang, Hu, Zhengqing

“…Regeneration of mature mammalian inner ear hair cells remains to be a challenge. This study aims to evaluate the ability of DNA methyltransferase (Dnmt)…”
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Postnatal Changes of Neural Stem Cells in the Mammalian Auditory Cortex by Hu, Zhengqing, Tao, Li, Deng, Meng

“…Our previous study reported neural stem cells (NSCs) in the auditory cortex (AC) of postnatal day 3 (P3) mice in vitro. It is unclear whether AC-NSCs exist in…”
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Epigenetic DNA Demethylation Causes Inner Ear Stem Cell Differentiation into Hair Cell-Like Cells by Zhou, Yang, Hu, Zhengqing

“…The DNA methyltransferase (DNMT) inhibitor 5-azacytidine (5-aza) causes genomic demethylation to regulate gene expression. However, it remains unclear whether…”
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Embryonic Stem Cell-Derived Peripheral Auditory Neurons Form Neural Connections with Mouse Central Auditory Neurons In Vitro via the α2δ1 Receptor by Liu, Zhenjie, Jiang, Yiyun, Li, Xiaoyang, Hu, Zhengqing

“…Integration of stem cell-derived neurons into the central nervous system (CNS) remains a challenge. A co-culture system is developed to understand whether…”
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Generation of a Spiral Ganglion Neuron Degeneration Mouse Model by Hu, Zhengqing, Komal, Fnu, Singh, Aditi, Deng, Meng

“…Spiral ganglion neurons (SGNs) can be injured by a wide variety of insults. However, there still is a lack of degeneration models to specifically damage the…”
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Concentration-dependent effect of nerve growth factor on cell fate determination of neural progenitors by Zhang, Lei, Jiang, Hui, Hu, Zhengqing

“…Stem cell-based spiral ganglion neuron (SGN) replacement therapy has been proposed to be a promising strategy to restore hearing either via replacing…”
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The potential of stem cells for the restoration of auditory function in humans by Hu, Zhengqing, Ulfendahl, Mats

“…Hearing loss is one of the most common disabilities, affecting approximately 10% of the population. Hair cells and spiral ganglion neurons are usually damaged…”
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Inner Ear Hair Cells Produced in vitro by a Mesenchymal-to-Epithelial Transition by Hu, Zhengqing, Corwin, Jeffrey T.

“…Sensory hair cell loss is a major contributor to disabling hearing and balance deficits that affect >250 million people worldwide. Sound exposures, infections,…”
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Angiotensin II Facilitates Matrix Metalloproteinase-9-Mediated Myosin Light Chain Kinase Degradation in Pressure Overload-Induced Cardiac Hypertrophy by Wang, Shun, Cheng, Mian, Hu, Zhengqing, Hu, Shan, Zou, Qiang, Lai, Xin, Liu, Beilei, Jiang, Hong, Huang, Congxin, Wu, Gang

“…Background/Aims: Angiotensin II (Ang II) has been shown to promote cardiac remodeling during the process of hypertrophy. Myosin light chain kinase (MLCK), a…”
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Genome-Wide Demethylation by 5-aza-2’-Deoxycytidine Alters the Cell Fate of Stem/Progenitor Cells by Zhou, Yang, Hu, Zhengqing

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Central migration of neuronal tissue and embryonic stem cells following transplantation along the adult auditory nerve by Hu, Zhengqing, Ulfendahl, Mats, Olivius, N. Petri

“…The regeneration of the auditory nerve remains a challenge in restoring hearing. An interesting approach would be to use a cell replacement therapy with the…”
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Survival of neuronal tissue following xenograft implantation into the adult rat inner ear by Hu, Zhengqing, Ulfendahl, Mats, Olivius, N.Petri

“…The poor regenerative capacity of the spiral ganglion neurons of the mammalian inner ear has initiated research on how to assist the functional recovery of the…”
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Neural cograft stimulates the survival and differentiation of embryonic stem cells in the adult mammalian auditory system by Hu, Zhengqing, Andäng, Michael, Ni, Daofeng, Ulfendahl, Mats

“…Mouse embryonic stem (ES) cells were transplanted into the cochlea of adult guinea pigs in order to explore their survival, differentiation, and possible…”
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Functional evaluation of a cell replacement therapy in the inner ear by Hu, Zhengqing, Ulfendahl, Mats, Prieskorn, Diane M, Olivius, Petri, Miller, Josef M

“…Cell replacement therapy in the inner ear will contribute to the functional recovery of hearing loss. Cell replacement therapy is a potentially powerful…”
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NGF stimulates extensive neurite outgrowth from implanted dorsal root ganglion neurons following transplantation into the adult rat inner ear by Hu, Zhengqing, Ulfendahl, Mats, Petri Olivius, N.

“…Neuronal tissue transplantation is a potential way to replace degenerated spiral ganglion neurons (SGNs) since these cells cannot regenerate in adult mammals…”
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Aligned contiguous microfiber platform enhances neural differentiation of embryonic stem cells by Liu, Zhenjie, Hu, Zhengqing

“…A microfiber platform that is able to enhance neuronal differentiation and guide aligned neurite outgrowths is essential to the repair of nerve damage. To…”
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A cell therapy approach to substitute neural elements in the inner ear by Ulfendahl, Mats, Hu, Zhengqing, Olivius, Petri, Duan, Maoli, Wei, Dongguang

“…Abstract Three different donor tissues were tested for their capacity to survive, integrate and differentiate in the adult inner ear. Surviving embryonic…”
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Myelination of the postnatal mouse cochlear nerve at the peripheral-central nervous system transitional zone by Wang, Jue, Zhang, Baofu, Jiang, Hui, Zhang, Lei, Liu, Danzheng, Xiao, Xiao, Ma, Hannah, Luo, Xuemei, Bojrab, 2nd, Dennis, Hu, Zhengqing

“…In the nerve roots of vertebrates, the peripheral nervous system (PNS) and central nervous system (CNS) interface at the PNS-CNS transitional zone (PCTZ),…”
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