Search Results - "Hu, Zeping"

Integrated cytokine and metabolite analysis reveals immunometabolic reprogramming in COVID-19 patients with therapeutic implications by Xiao, Nan, Nie, Meng, Pang, Huanhuan, Wang, Bohong, Hu, Jieli, Meng, Xiangjun, Li, Ke, Ran, Xiaorong, Long, Quanxin, Deng, Haijun, Chen, Na, Li, Shao, Tang, Ni, Huang, Ailong, Hu, Zeping

“…Cytokine release syndrome (CRS) is a major cause of the multi-organ injury and fatal outcome induced by SARS-CoV-2 infection in severe COVID-19 patients…”
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Metabolomics, metabolic flux analysis and cancer pharmacology by Liang, Lingfan, Sun, Fei, Wang, Hongbo, Hu, Zeping

“…Metabolic reprogramming is a hallmark of cancer and increasing evidence suggests that reprogrammed cell metabolism supports tumor initiation, progression,…”
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The Gut Commensal Bacteroides thetaiotaomicron Exacerbates Enteric Infection through Modification of the Metabolic Landscape by Curtis, Meredith M., Hu, Zeping, Klimko, Claire, Narayanan, Sanjeev, Deberardinis, Ralph, Sperandio, Vanessa

“…The enteric pathogen enterohemorrhagic Escherichia coli (EHEC) causes severe diarrhea, but the influence of the gut microbiota on EHEC infection is largely…”
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Metabolomics in drug research and development: The recent advances in technologies and applications by Pang, Huanhuan, Hu, Zeping

“…Emerging evidence has demonstrated the vital role of metabolism in various diseases or disorders. Metabolomics provides a comprehensive understanding of…”
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Induction of mouse totipotent stem cells by a defined chemical cocktail by Hu, Yanyan, Yang, Yuanyuan, Tan, Pengcheng, Zhang, Yuxia, Han, Mengxia, Yu, Jiawei, Zhang, Xin, Jia, Zeran, Wang, Dan, Yao, Ke, Pang, Huanhuan, Hu, Zeping, Li, Yinqing, Ma, Tianhua, Liu, Kang, Ding, Sheng

“…In mice, only the zygotes and blastomeres from 2-cell embryos are authentic totipotent stem cells (TotiSCs) capable of producing all the differentiated cells…”
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Evolutionary metabolic landscape from preneoplasia to invasive lung adenocarcinoma by Nie, Meng, Yao, Ke, Zhu, Xinsheng, Chen, Na, Xiao, Nan, Wang, Yi, Peng, Bo, Yao, LiAng, Li, Peng, Zhang, Peng, Hu, Zeping

“…Metabolic reprogramming evolves during cancer initiation and progression. However, thorough understanding of metabolic evolution from preneoplasia to lung…”
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Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing by Ma, Xiao-Ru, Zhu, Xudong, Xiao, Yujie, Gu, Hui-Min, Zheng, Shuang-Shuang, Li, Liang, Wang, Fan, Dong, Zhao-Jun, Wang, Di-Xian, Wu, Yang, Yang, Chenyu, Jiang, Wenhong, Yao, Ke, Yin, Yue, Zhang, Yang, Peng, Chao, Gao, Lixia, Meng, Zhuoxian, Hu, Zeping, Liu, Chong, Li, Li, Chen, Hou-Zao, Shu, Yousheng, Ju, Zhenyu, Zhao, Jing-Wei

“…The age-dependent decline in remyelination potential of the central nervous system during ageing is associated with a declined differentiation capacity of…”
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Targeting the Oncogene KRAS Mutant Pancreatic Cancer by Synergistic Blocking of Lysosomal Acidification and Rapid Drug Release by Kong, Chao, Li, Yang, Liu, Zhengsheng, Ye, Junxiao, Wang, Zhaohui, Zhang, Ling, Kong, Weijian, Liu, Huiqin, Liu, Chun, Pang, Huanhuan, Hu, Zeping, Gao, Jinming, Qian, Feng

“…Survival of KRAS mutant pancreatic cancer is critically dependent on reprogrammed metabolism including elevated macropinocytosis, autophagy, and lysosomal…”
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Targeting acetylcholine signaling modulates persistent drug tolerance in EGFR-mutant lung cancer and impedes tumor relapse by Nie, Meng, Chen, Na, Pang, Huanhuan, Jiang, Tao, Jiang, Wei, Tian, Panwen, Yao, LiAng, Chen, Yangzi, DeBerardinis, Ralph J, Li, Weimin, Yu, Qitao, Zhou, Caicun, Hu, Zeping

“…Although first-line epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy is effective for treating EGFR-mutant non-small cell lung…”
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MYC-Driven Small-Cell Lung Cancer is Metabolically Distinct and Vulnerable to Arginine Depletion by Chalishazar, Milind D, Wait, Sarah J, Huang, Fang, Ireland, Abbie S, Mukhopadhyay, Anandaroop, Lee, Younjee, Schuman, Sophia S, Guthrie, Matthew R, Berrett, Kristofer C, Vahrenkamp, Jeffery M, Hu, Zeping, Kudla, Marek, Modzelewska, Katarzyna, Wang, Guoying, Ingolia, Nicholas T, Gertz, Jason, Lum, David H, Cosulich, Sabina C, Bomalaski, John S, DeBerardinis, Ralph J, Oliver, Trudy G

“…Small-cell lung cancer (SCLC) has been treated clinically as a homogeneous disease, but recent discoveries suggest that SCLC is heterogeneous. Whether…”
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CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells by Kim, Jiyeon, Hu, Zeping, Cai, Ling, Li, Kailong, Choi, Eunhee, Faubert, Brandon, Bezwada, Divya, Rodriguez-Canales, Jaime, Villalobos, Pamela, Lin, Yu-Fen, Ni, Min, Huffman, Kenneth E., Girard, Luc, Byers, Lauren A., Unsal-Kacmaz, Keziban, Peña, Christopher G., Heymach, John V., Wauters, Els, Vansteenkiste, Johan, Castrillon, Diego H., Chen, Benjamin P. C., Wistuba, Ignacio, Lambrechts, Diether, Xu, Jian, Minna, John D., DeBerardinis, Ralph J.

“…In human cell lines with mutant KRAS and loss of LKB1, CPS1 expression correlates inversely with LKB1 expression; silencing CPS1 in these cells induces DNA…”
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Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation by Liu, Xin, Zhang, Yuannyu, Ni, Min, Cao, Hui, Signer, Robert A. J., Li, Dan, Li, Mushan, Gu, Zhimin, Hu, Zeping, Dickerson, Kathryn E., Weinberg, Samuel E., Chandel, Navdeep S., DeBerardinis, Ralph J., Zhou, Feng, Shao, Zhen, Xu, Jian

“…Advances in genomic profiling present new challenges of explaining how changes in DNA and RNA are translated into proteins linking genotype to phenotype. Here…”
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Neddylation inhibition induces glutamine uptake and metabolism by targeting CRL3SPOP E3 ligase in cancer cells by Zhou, Qiyin, Lin, Wenyu, Wang, Chaoqun, Sun, Fei, Ju, Siwei, Chen, Qian, Wang, Yi, Chen, Yongxia, Li, Haomin, Wang, Linbo, Hu, Zeping, Jin, Hongchuan, Wang, Xian, Sun, Yi

“…Abnormal neddylation activation is frequently observed in human cancers and neddylation inhibition has been proposed as a therapy for cancer. Here, we report…”
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Metabolomic machine learning predictor for diagnosis and prognosis of gastric cancer by Chen, Yangzi, Wang, Bohong, Zhao, Yizi, Shao, Xinxin, Wang, Mingshuo, Ma, Fuhai, Yang, Laishou, Nie, Meng, Jin, Peng, Yao, Ke, Song, Haibin, Lou, Shenghan, Wang, Hang, Yang, Tianshu, Tian, Yantao, Han, Peng, Hu, Zeping

“…Gastric cancer (GC) represents a significant burden of cancer-related mortality worldwide, underscoring an urgent need for the development of early detection…”
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Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects by Mullen, Andrew R., Hu, Zeping, Shi, Xiaolei, Jiang, Lei, Boroughs, Lindsey K., Kovacs, Zoltan, Boriack, Richard, Rakheja, Dinesh, Sullivan, Lucas B., Linehan, W. Marston, Chandel, Navdeep S., DeBerardinis, Ralph J.

“…Mammalian cells generate citrate by decarboxylating pyruvate in the mitochondria to supply the tricarboxylic acid (TCA) cycle. In contrast, hypoxia and other…”
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Treatment of SARS-CoV-2-induced pneumonia with NAD+ and NMN in two mouse models by Jiang, Yisheng, Deng, Yongqiang, Pang, Huanhuan, Ma, Tiantian, Ye, Qing, Chen, Qi, Chen, Haiyang, Hu, Zeping, Qin, Cheng-Feng, Xu, Zhiheng

“…The global COVID-19 epidemic has spread rapidly around the world and caused the death of more than 5 million people. It is urgent to develop effective…”
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MCT4 Defines a Glycolytic Subtype of Pancreatic Cancer with Poor Prognosis and Unique Metabolic Dependencies by Baek, GuemHee, Tse, Yan F., Hu, Zeping, Cox, Derek, Buboltz, Noah, McCue, Peter, Yeo, Charles J., White, Michael A., DeBerardinis, Ralph J., Knudsen, Erik S., Witkiewicz, Agnieszka K.

“…KRAS mutation, which occurs in ∼95% of pancreatic ductal adenocarcinoma (PDA), has been shown to program tumor metabolism. MCT4 is highly upregulated in a…”
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Publisher Correction: Neddylation inhibition induces glutamine uptake and metabolism by targeting CRL3SPOP E3 ligase in cancer cells by Zhou, Qiyin, Lin, Wenyu, Wang, Chaoqun, Sun, Fei, Ju, Siwei, Chen, Qian, Wang, Yi, Chen, Yongxia, Li, Haomin, Wang, Linbo, Hu, Zeping, Jin, Hongchuan, Wang, Xian, Sun, Yi

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A reversed-phase capillary ultra-performance liquid chromatography–mass spectrometry (UPLC-MS) method for comprehensive top-down/bottom-up lipid profiling by Gao, Xiaoli, Zhang, Qibin, Meng, Da, Isaac, Giorgis, Zhao, Rui, Fillmore, Thomas L., Chu, Rosey K., Zhou, Jianying, Tang, Keqi, Hu, Zeping, Moore, Ronald J., Smith, Richard D., Katze, Michael G., Metz, Thomas O.

“…Lipidomics is a critical part of metabolomics and aims to study all the lipids within a living system. We present here the development and evaluation of a…”
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Circulatory metabolites trigger ex vivo arterial endothelial cell dysfunction in population chronically exposed to diesel exhaust by Cheng, Wenting, Pang, Huanhuan, Campen, Matthew J, Zhang, Jianzhong, Li, Yanting, Gao, Jinling, Ren, Dunqiang, Ji, Xiaoya, Rothman, Nathaniel, Lan, Qing, Zheng, Yuxin, Leng, Shuguang, Hu, Zeping, Tang, Jinglong

“…Chronic exposure to diesel exhaust has a causal link to cardiovascular diseases in various environmental and occupational settings. Arterial endothelial cell…”
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