Search Results - "Hu, Yujian"
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Neutrophil extracellular traps induced by IL-1β promote endothelial dysfunction and aggravate limb ischemia
Published in Hypertension research (01-06-2024)“…Vascular inflammation and endothelial dysfunction contribute to vascular diseases. While neutrophil extracellular traps (NETs) participate in some vascular…”
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Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine C‑Nucleosides as Favipiravir (T-705) Analogues
Published in Journal of medicinal chemistry (26-05-2016)“…Influenza viruses are responsible for seasonal epidemics and occasional pandemics which cause significant morbidity and mortality. Despite available vaccines,…”
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Synthesis and Anti-HCV Activities of 4′-Fluoro-2′-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4′-Fluoro-2′‑C‑methyluridine 5′-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection
Published in Journal of medicinal chemistry (09-05-2019)“…We report the synthesis and biological evaluation of a series of 4′-fluoro-2′-C-substituted uridines. Triphosphates of the uridine analogues exhibited a potent…”
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Acute Renal Infarction Due to Symptomatic Isolated Spontaneous Renal Artery Dissection: A Rare and Fatal Disease
Published in Journal of endovascular therapy (08-05-2023)“…Objective: To report demographics and clinical, laboratory, and imaging features of acute renal infarction (ARI) due to symptomatic isolated spontaneous renal…”
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Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of AL-611 as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C
Published in Journal of medicinal chemistry (24-09-2020)“…Chronic hepatitis C (CHC) is a major liver disease caused by the hepatitis C virus. The current standard of care for CHC can achieve cure rates above 95%;…”
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Cross-Phase Mutual Learning Framework for Pulmonary Embolism Identification on Non-Contrast CT Scans
Published 16-07-2024“…Pulmonary embolism (PE) is a life-threatening condition where rapid and accurate diagnosis is imperative yet difficult due to predominantly atypical…”
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Rapid and Accurate Diagnosis of Acute Aortic Syndrome using Non-contrast CT: A Large-scale, Retrospective, Multi-center and AI-based Study
Published 13-06-2024“…Chest pain symptoms are highly prevalent in emergency departments (EDs), where acute aortic syndrome (AAS) is a catastrophic cardiovascular emergency with a…”
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