Search Results - "Hu, Youcai"

Enzymatic dimerization in the biosynthetic pathway of microbial natural products by Liu, Jiawang, Liu, Anan, Hu, Youcai

“…Covering: up to August 2020The dramatic increase in the identification of dimeric natural products generated by microorganisms and plants has played a…”
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Enzymatic Intermolecular Hetero-Diels–Alder Reaction in the Biosynthesis of Tropolonic Sesquiterpenes by Chen, Qibin, Gao, Jie, Jamieson, Cooper, Liu, Jiawang, Ohashi, Masao, Bai, Jian, Yan, Daojian, Liu, Bingyu, Che, Yongsheng, Wang, Yanan, Houk, K. N, Hu, Youcai

“…Diels–Alder reactions are among the most powerful synthetic transformations to construct complex natural products. Despite that increasing of enzymatic…”
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Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1 by Sun, Qingxiang, Carrasco, Yazmin P., Hu, Youcai, Guo, Xiaofeng, Mirzaei, Hamid, MacMillan, John, Chook, Yuh Min

“…The polyketide natural product Leptomycin B inhibits nuclear export mediated by the karyopherin protein chromosomal region maintenance 1 (CRM1). Here, we…”
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Erythrazoles A–B, Cytotoxic Benzothiazoles from a Marine-Derived Erythrobacter sp by Hu, Youcai, MacMillan, John B

“…Chemical examination of an extract from an Erythrobacter sp. isolated from mangrove sediments yielded erythrazoles A (1) and B (2). The erythrazoles are of…”
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Biosynthesis of Heptacyclic Duclauxins Requires Extensive Redox Modifications of the Phenalenone Aromatic Polyketide by Gao, Shu-Shan, Zhang, Tao, Garcia-Borràs, Marc, Hung, Yiu-Sun, Billingsley, John M, Houk, K. N, Hu, Youcai, Tang, Yi

“…Duclauxins are dimeric and heptacyclic fungal polyketides with notable bioactivities. We characterized the cascade of redox transformations in the biosynthetic…”
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Epigenetic Genome Mining of an Endophytic Fungus Leads to the Pleiotropic Biosynthesis of Natural Products by Mao, Xu-Ming, Xu, Wei, Li, Dehai, Yin, Wen-Bing, Chooi, Yit-Heng, Li, Yong-Quan, Tang, Yi, Hu, Youcai

“…The small‐molecule biosynthetic potential of most filamentous fungi has remained largely unexplored and represents an attractive source for the discovery of…”
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Genome mining combined metabolic shunting and OSMAC strategy of an endophytic fungus leads to the production of diverse natural products by Wei, Qian, Bai, Jian, Yan, Daojiang, Bao, Xiuqi, Li, Wenting, Liu, Bingyu, Zhang, Dan, Qi, Xiangbing, Yu, Dequan, Hu, Youcai

“…Endophytic fungi are promising producers of bioactive small molecules. Bioinformatic analysis of the genome of an endophytic fungus Penicillium dangeardii…”
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A Cascade of Redox Reactions Generates Complexity in the Biosynthesis of the Protein Phosphatase‐2 Inhibitor Rubratoxin A by Bai, Jian, Yan, Daojiang, Zhang, Tao, Guo, Yongzhi, Liu, Yunbao, Zou, Yi, Tang, Mancheng, Liu, Bingyu, Wu, Qiong, Yu, Shishan, Tang, Yi, Hu, Youcai

“…Redox modifications are key complexity‐generating steps in the biosynthesis of natural products. The unique structure of rubratoxin A (1), many of which arise…”
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A carbonate-forming Baeyer-Villiger monooxygenase by Hu, Youcai, Dietrich, David, Xu, Wei, Patel, Ashay, Thuss, Justin A J, Wang, Jingjing, Yin, Wen-Bing, Qiao, Kangjian, Houk, K N, Vederas, John C, Tang, Yi

“…Carbonates exist in a few natural products, but their biosynthetic origins have been unclear. Genetic and biochemical characterization of a flavin-dependent…”
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Coordinated Biosynthesis of the Purine Nucleoside Antibiotics Aristeromycin and Coformycin in Actinomycetes by Xu, Gudan, Kong, Liyuan, Gong, Rong, Xu, Liudong, Gao, Yaojie, Jiang, Ming, Cai, You-Sheng, Hong, Kui, Hu, Youcai, Liu, Peng, Deng, Zixin, Price, Neil P J, Chen, Wenqing

“…Purine nucleoside antibiotic pairs, concomitantly produced by a single strain, are an important group of microbial natural products. Here, we report a…”
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Biosynthesis of rumbrins and inspiration for discovery of HIV inhibitors by Zhong, Beifen, Wan, Jun, Shang, Changhui, Wen, Jiajia, Wang, Yujia, Bai, Jian, Cen, Shan, Hu, Youcai

“…Investigation on how nature produces natural compounds with chemical and biological diversity at the genetic level offers inspiration for the discovery of new…”
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Discovery of Cryptic Polyketide Metabolites from Dermatophytes Using Heterologous Expression in Aspergillus nidulans by Yin, Wen-Bing, Chooi, Yit Heng, Smith, Adam R, Cacho, Ralph A, Hu, Youcai, White, Theodore C, Tang, Yi

“…Dermatophytes belonging to the Trichophyton and Arthroderma genera cause skin infections in humans and animals. From genome sequencing data, we mined a…”
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Activation of an unconventional meroterpenoid gene cluster in Neosartorya glabra leads to the production of new berkeleyacetals by Zhang, Tao, Wan, Jun, Zhan, Zhajun, Bai, Jian, Liu, Bingyu, Hu, Youcai

“…Fungal genomes carry many gene clusters seemingly capable of natural products biosynthesis, yet most clusters remain cryptic or down-regulated. Genome mining…”
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Erythrolic acids A–E, Meroterpenoids from a Marine-Derived Erythrobacter sp by Hu, Youcai, Legako, Aaron G, Espindola, Ana Paula D.M, MacMillan, John B

“…Erythrolic acids A–E (1–5) are five unusual meroterpenoids isolated from the bacterium Erythrobacter sp. derived from a marine sediment sample collected in…”
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Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscula leads to diverse diterpenoids by Bai, Jian, Mu, Rong, Dou, Man, Yan, Daojiang, Liu, Bingyu, Wei, Qian, Wan, Jun, Tang, Yi, Hu, Youcai

“…Epigenetic modifications have been proved to be a powerful way to activate silent gene clusters and lead to diverse secondary metabolites in fungi. Previously,…”
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New vernocuminosides from the stem barks of Vernonia cumingiana Benth by Liu, Jing, Liu, Yunbao, Si, Yikang, Yu, Shishan, Qu, Jing, Xu, Song, Hu, Youcai, Ma, Shuanggang

“…Seven new stigmastane-type steroidal glycosides, vernocuminosides A–G ( 1– 7), have been isolated from the stem barks of Vernonia cumingiana Benth. The…”
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Discovery and evolution of [4 + 2] cyclases by Liu, Jiawang, Hu, Youcai

“…[4 + 2] Cyclases are potent biocatalysts that have been bestowed upon microorganisms and plants by nature, equipping them with the powerful tools to utilize…”
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Chromomycin SA analogs from a marine-derived Streptomyces sp by Hu, Youcai, Espindola, Ana Paula D.M., Stewart, Nathan A., Wei, Shuguang, Posner, Bruce A., MacMillan, John B.

“…Two chromomycin SA analogs, chromomycin SA3 and chromomycin SA2, along with deacetylchromomycin A3 and five previously reported chromomycin analogs were…”
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Targeted Isolation and Structure Elucidation of Stilbene Glycosides from the Bark of Lysidice brevicalyx Wei Guided by Biological and Chemical Screening by Hu, Youcai, Ma, Shuanggang, Li, Jianbei, Yu, Shishan, Qu, Jing, Liu, Jing, Du, Dan

“…An efficient procedure based on biological and chemical screening has been performed to investigate the antioxidant constituents of the bark of Lysidice…”
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Structural characterization of trace stilbene glycosides in Lysidice brevicalyx Wei using liquid chromatography/diode-array detection/electrospray ionization tandem mass spectrometry by Hu, Youcai, Qu, Jing, Liu, Yuanyan, Yu, Shishan, Li, Jianbei, Zhang, Jinlan, Du, Dan

“…The mass fragmentation patterns of stilbene glycosides isolated from the genus Lysidice were investigated by negative ion electrospray ionization tandem mass…”
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