Search Results - "Hu, Xiu F."
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Regulation of MDR1 gene expression: emerging concepts
Published in Drug resistance updates (01-04-2000)“…Drug resistance genes, such as MDR1, involved in drug efflux, and their regulation have been the subject of intense research efforts in the past 10 years. Many…”
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Induction of insulin-like growth factor binding protein expression by ICI 182,780 in a tamoxifen-resistant human breast cancer cell line
Published in Breast cancer research and treatment (01-06-1999)“…Earlier studies in our laboratory demonstrated that the steroidal antiestrogen ICI 182,780 is very effective in abolishing the tamoxifen-resistant…”
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The pure antiestrogen ICI 182,780 binds to a high-affinity site distinct from the estrogen receptor
Published in International journal of cancer (09-08-1995)“…Both estrogen receptor-positive (ER+), tamoxifen-sensitive (5-21) and tamoxifen-resistant (5-23) subclones of the parental MCF-7 breast cancer cell line were…”
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Cellular and karyotypic characterization of two doxorubicin resistant cell lines isolated from the same parental human leukemia cell line
Published in International journal of cancer (15-05-1994)“…Separate mechanisms underlying the multidrug resistant (MDR) phenotype were identified in 2 independent approaches to select tumour cells resistant to low…”
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Differential effects of estrogen, tamoxifen and the pure antiestrogen ICI 182,780 in human drug-resistant leukemia cell lines
Published in Cancer chemotherapy and pharmacology (01-03-1993)“…ICI 182,780, a potent, new steroidal antiestrogen without apparent agonist activity, appears to be a potent modulator of the classic multidrug resistance (MDR)…”
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Altered methylation of the human MDR1 promoter is associated with acquired multidrug resistance
Published in Clinical cancer research (01-11-1997)“…One of the most important forms of drug resistance in acute myeloid leukemia is the multidrug resistance (MDR) phenotype, which is characterized by the…”
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Altered Multidrug Resistance Phenotype Caused by Anthracycline Analogues and Cytosine Arabinoside in Myeloid Leukemia
Published in Blood (15-06-1999)“…The expression of P-glycoprotein (Pgp) is often increased in acute myeloid leukemia (AML). However, little is known of the regulation of Pgp expression by…”
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Altered Multidrug Resistance Phenotype Caused by Anthracycline Analogues and Cytosine Arabinoside in Myeloid Leukemia
Published in Blood (15-06-1999)“…The expression of P-glycoprotein (Pgp) is often increased in acute myeloid leukemia (AML). However, little is known of the regulation of Pgp expression by…”
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Combined use of cyclosporin A and verapamil in modulating multidrug resistance in human leukemia cell lines
Published in Cancer research (Chicago, Ill.) (15-05-1990)“…This study describes the synergistic interaction of two biochemical modulators, cyclosporin A (CyA) and verapamil (Vp), in multidrug-resistant cells, the…”
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Cyclosporin A and PSC 833 prevent up-regulation of MDR1 expression by anthracyclines in a human multidrug-resistant cell line
Published in Clinical cancer research (01-04-1996)“…We have previously demonstrated that within 24 h of exposure of the CEM/A7R cell line to epirubicin (EPI), MDR1 gene expression is induced. The aim of the…”
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