Search Results - "Hu, Xianglong"

Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy by Zhang, Wenjia, Hu, Xianglong, Shen, Qi, Xing, Da

“…Cancer cells exhibit slightly elevated levels of reactive oxygen species (ROS) compared with normal cells, and approximately 90% of intracellular ROS is…”
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Cell-Penetrating Hyperbranched Polyprodrug Amphiphiles for Synergistic Reductive Milieu-Triggered Drug Release and Enhanced Magnetic Resonance Signals by Hu, Xianglong, Liu, Guhuan, Li, Yang, Wang, Xiaorui, Liu, Shiyong

“…The rational design of theranostic nanoparticles exhibiting synergistic turn-on of therapeutic potency and enhanced diagnostic imaging in response to tumor…”
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Polyprodrug Antimicrobials: Remarkable Membrane Damage and Concurrent Drug Release to Combat Antibiotic Resistance of Methicillin‐Resistant Staphylococcus aureus by Cao, Bing, Xiao, Fengfeng, Xing, Da, Hu, Xianglong

“…The increased threat of antibiotic resistance has created an urgent need for new strategies. Herein, polyprodrug antimicrobials are proposed to mimic…”
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Mitochondrial specific photodynamic therapy by rare-earth nanoparticles mediated near-infrared graphene quantum dots by Zhang, Dandan, Wen, Liewei, Huang, Ru, Wang, Huanhuan, Hu, Xianglong, Xing, Da

“…Photodynamic therapy (PDT) has been proposed in cancer treatment for decades, but its clinical translation is significantly impeded by the low yield of ROS,…”
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Polyprodrug Amphiphiles: Hierarchical Assemblies for Shape-Regulated Cellular Internalization, Trafficking, and Drug Delivery by Hu, Xianglong, Hu, Jinming, Tian, Jie, Ge, Zhishen, Zhang, Guoying, Luo, Kaifu, Liu, Shiyong

“…Solution self-assembly of block copolymers (BCPs) typically generates spheres, rods, and vesicles. The reproducible bottom-up fabrication of stable planar…”
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Pulsed Laser Excited Photoacoustic Effect for Disease Diagnosis and Therapy by Wang, Zhixiong, Zhan, Meixiao, Hu, Xianglong

“…Pulsed laser can excite light absorber to generate photoacoustic (PA) effect, that is, when the absorber is irradiated with pulsed laser, the absorbed light…”
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Concurrent Drug Unplugging and Permeabilization of Polyprodrug‐Gated Crosslinked Vesicles for Cancer Combination Chemotherapy by Hu, Xianglong, Zhai, Shaodong, Liu, Guhuan, Xing, Da, Liang, Haojun, Liu, Shiyong

“…Combination chemotherapy with both hydrophobic and hydrophilic therapeutic drugs is clinically vital toward the treatment of persistent cancers. Though…”
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Rational collaborative ablation of bacterial biofilms ignited by physical cavitation and concurrent deep antibiotic release by Cao, Bing, Lyu, Xiaoming, Wang, Congyu, Lu, Siyu, Xing, Da, Hu, Xianglong

“…Bacteria biofilm has extracellular polymeric substances to protect bacteria from external threats, which is a stubborn problem for human health. Herein, a kind…”
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Light-driven transformable optical agent with adaptive functions for boosting cancer surgery outcomes by Qi, Ji, Chen, Chao, Zhang, Xiaoyan, Hu, Xianglong, Ji, Shenglu, Kwok, Ryan T. K., Lam, Jacky W. Y., Ding, Dan, Tang, Ben Zhong

“…Fluorescence and photoacoustic imaging have different advantages in cancer diagnosis; however, combining effects in one agent normally requires a trade-off as…”
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Photo-Triggered Release of Caged Camptothecin Prodrugs from Dually Responsive Shell Cross-Linked Micelles by Hu, Xianglong, Tian, Jie, Liu, Tao, Zhang, Guoying, Liu, Shiyong

“…We report on the fabrication of dynamic covalent shell cross-linked (SCL) micelles with hydrophobic cores conjugated with photocaged chemotherapeutic drugs and…”
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Recent advances towards the fabrication and biomedical applications of responsive polymeric assemblies and nanoparticle hybrid superstructures by Hu, Xianglong, Liu, Shiyong

“…Responsive polymeric assemblies and hybrid superstructures fabricated from stimuli-sensitive polymers and inorganic nanoparticles (NPs) have been the subject…”
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Rational design of a water-soluble NIR AIEgen, and its application in ultrafast wash-free cellular imaging and photodynamic cancer cell ablation by Wang, Dong, Su, Huifang, Kwok, Ryan T K, Hu, Xianglong, Zou, Hang, Luo, Qianxin, Lee, Michelle M S, Xu, Wenhan, Lam, Jacky W Y, Tang, Ben Zhong

“…The synthesis of water-soluble near-infrared (NIR)-emissive fluorescent molecules with aggregation-induced emission (AIE) characteristics and theranostic…”
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Amphiphilic multiarm star block copolymer-based multifunctional unimolecular micelles for cancer targeted drug delivery and MR imaging by Li, Xiaojie, Qian, Yinfeng, Liu, Tao, Hu, Xianglong, Zhang, Guoying, You, Yezi, Liu, Shiyong

“…Abstract We report on the fabrication of multifunctional polymeric unimolecular micelles as an integrated platform for cancer targeted drug delivery and…”
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Cascade-Promoted Photo-Chemotherapy against Resistant Cancers by Enzyme-Responsive Polyprodrug Nanoplatforms by Wang, Wenhui, Liang, Guohai, Zhang, Wenjia, Xing, Da, Hu, Xianglong

“…Cisplatin has long been the first-line treatment for a variety of solid tumors. However, the poor pharmacokinetics and intrinsic or acquired drug resistance…”
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Highly efficient singlet oxygen generation, two-photon photodynamic therapy and melanoma ablation by rationally designed mitochondria-specific near-infrared AIEgens by Zheng, Zheng, Liu, Haixiang, Zhai, Shaodong, Zhang, Haoke, Shan, Guogang, Kwok, Ryan T. K, Ma, Chao, Sung, Herman H. Y, Williams, Ian D, Lam, Jacky W. Y, Wong, Kam Sing, Hu, Xianglong, Tang, Ben Zhong

“…Photosensitizers (PSs) with multiple characteristics, including efficient singlet oxygen ( 1 O 2 ) generation, cancer cell-selective accumulation and…”
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Fast surface immobilization of native proteins through catalyst-free amino-yne click bioconjugation by Zhang, Yiru, Shen, Jianlei, Hu, Rong, Shi, Xiujuan, Hu, Xianglong, He, Benzhao, Qin, Anjun, Tang, Ben Zhong

“…Surface immobilization provides a useful platform for biosensing, drug screening, tissue engineering and other chemical and biological applications. However,…”
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Photosensitizer conjugate-functionalized poly(hexamethylene guanidine) for potentiated broad-spectrum bacterial inhibition and enhanced biocompatibility by Xiao, Fengfeng, Cao, Bing, Wen, Liewei, Su, Yanhong, Zhan, Meixiao, Lu, Ligong, Hu, Xianglong

“…A broad-spectrum polymeric antimicrobial, PEoS-PHMG, was developed to achieve dual-modality bacterial inhibition via photodynamic inactivation and physical…”
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Author Correction: Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy by Zhang, Wenjia, Hu, Xianglong, Shen, Qi, Xing, Da

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Author Correction: Mitochondria-specific drug release and reactive oxygen species burst induced by polyprodrug nanoreactors can enhance chemotherapy by Zhang, Wenjia, Hu, Xianglong, Shen, Qi, Xing, Da

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Targeted Delivery of Bleomycin: A Comprehensive Anticancer Review by Yu, Zhiqiang, Yan, Bo, Gao, Liqian, Dong, Chenbo, Zhong, Jian, D Ortenzio, Mathew, Nguyen, Brandon, Seong Lee, Su, Hu, Xianglong, Liang, Feng

“…Despite being one of the most effective broad-spectrum chemotherapeutic agents in the treatment of cancers, the clinical applications of bleomycins (BLMs) have…”
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