Internet of medical things (IoMT)-integrated biosensors for point-of-care testing of infectious diseases

On global scale, the current situation of pandemic is symptomatic of increased incidences of contagious diseases caused by pathogens. The faster spread of these diseases, in a moderately short timeframe, is threatening the overall population wellbeing and conceivably the economy. The inadequacy of c...

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Bibliographic Details
Published in:	Biosensors & bioelectronics Vol. 179; p. 113074
Main Authors:	Jain, Shikha, Nehra, Monika, Kumar, Rajesh, Dilbaghi, Neeraj, Hu, TonyY, Kumar, Sandeep, Kaushik, Ajeet, Li, Chen-zhong
Format:	Journal Article
Language:	English
Published:	England Elsevier B.V 01-05-2021
Subjects:	Animals Artificial Intelligence Biosensing Techniques - instrumentation Biosensing Techniques - methods Biosensor Communicable Diseases - diagnosis Coronavirus Infections - diagnosis COVID-19 - diagnosis Dengue - diagnosis Equipment Design Hemorrhagic Fever, Ebola - diagnosis HIV Infections - diagnosis Humans Infectious diseases Influenza, Human - diagnosis Intelligent healthcare Internet of medical things Internet of Things Malaria - diagnosis Orthomyxoviridae Infections - diagnosis Point-of-Care Testing Zika Virus Infection - diagnosis Internet of medical things Intelligent healthcare Infectious diseases Artificial intelligence Biosensor Point-of-care-testing
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Summary:	On global scale, the current situation of pandemic is symptomatic of increased incidences of contagious diseases caused by pathogens. The faster spread of these diseases, in a moderately short timeframe, is threatening the overall population wellbeing and conceivably the economy. The inadequacy of conventional diagnostic tools in terms of time consuming and complex laboratory-based diagnosis process is a major challenge to medical care. In present era, the development of point-of-care testing (POCT) is in demand for fast detection of infectious diseases along with “on-site” results that are helpful in timely and early action for better treatment. In addition, POCT devices also play a crucial role in preventing the transmission of infectious diseases by offering real-time testing and lab quality microbial diagnosis within minutes. Timely diagnosis and further treatment optimization facilitate the containment of outbreaks of infectious diseases. Presently, efforts are being made to support such POCT by the technological development in the field of internet of medical things (IoMT). The IoMT offers wireless-based operation and connectivity of POCT devices with health expert and medical centre. In this review, the recently developed POC diagnostics integrated or future possibilities of integration with IoMT are discussed with focus on emerging and re-emerging infectious diseases like malaria, dengue fever, influenza A (H1N1), human papilloma virus (HPV), Ebola virus disease (EVD), Zika virus (ZIKV), and coronavirus (COVID-19). The IoMT-assisted POCT systems are capable enough to fill the gap between bioinformatics generation, big rapid analytics, and clinical validation. An optimized IoMT-assisted POCT will be useful in understanding the diseases progression, treatment decision, and evaluation of efficacy of prescribed therapy. •Infectious diseases are serious but manageable using intelligent diagnostics.•Biosensing enables low detection of virus needed for viral infection management.•IoMT-integrated biosensor enable diagnostics at site-of-infection efficiently.•IoMT-supported POC-biosensing enable viral infection management in personalized manner.•POC-biosensing is needed for diseases diagnostics and therapy decision along with investigation.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0956-5663 1873-4235
DOI:	10.1016/j.bios.2021.113074