Search Results - "Hu, Quanyin"

Tailoring Biomaterials for Cancer Immunotherapy: Emerging Trends and Future Outlook by Wang, Chao, Ye, Yanqi, Hu, Quanyin, Bellotti, Adriano, Gu, Zhen

“…Cancer immunotherapy, as a paradigm shift in cancer treatment, has recently received tremendous attention. The active cancer vaccination, immune checkpoint…”
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Depletion of tumor associated macrophages enhances local and systemic platelet-mediated anti-PD-1 delivery for post-surgery tumor recurrence treatment by Li, Zhaoting, Ding, Yingyue, Liu, Jun, Wang, Jianxin, Mo, Fanyi, Wang, Yixin, Chen-Mayfield, Ting-Jing, Sondel, Paul M., Hong, Seungpyo, Hu, Quanyin

“…Immunosuppressive cells residing in the tumor microenvironment, especially tumor associated macrophages (TAMs), hinder the infiltration and activation of T…”
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Proteolysis-targeting chimera (PROTAC) delivery system: advancing protein degraders towards clinical translation by Chen, Yu, Tandon, Ira, Heelan, William, Wang, Yixin, Tang, Weiping, Hu, Quanyin

“…Proteolysis Targeting Chimeras (PROTACs), an emerging therapeutic entity designed to degrade target proteins by hijacking the ubiquitin-proteasome system, have…”
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Recent advances in overcoming barriers to cell‐based delivery systems for cancer immunotherapy by Ding, Yingyue, Wang, Yixin, Hu, Quanyin

“…Immunotherapy strategies that use cell‐based delivery systems have sparked much interest in the treatment of malignancies, owing to their high…”
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Anticancer Platelet-Mimicking Nanovehicles by Hu, Quanyin, Sun, Wujin, Qian, Chengen, Wang, Chao, Bomba, Hunter N., Gu, Zhen

“…A core–shell nanovehicle coated with a platelet membrane (PM) is developed for targeted and site‐specific delivery of an extracellularly active drug and an…”
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Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing by Sun, Wujin, Ji, Wenyan, Hall, Jordan M., Hu, Quanyin, Wang, Chao, Beisel, Chase L., Gu, Zhen

“…CRISPR–Cas9 represents a promising platform for genome editing, yet means for its safe and efficient delivery remain to be fully realized. A novel vehicle that…”
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Sequentially Site-Specific Delivery of Thrombolytics and Neuroprotectant for Enhanced Treatment of Ischemic Stroke by Xu, Jianpei, Wang, Xiaoqi, Yin, Haoyuan, Cao, Xiang, Hu, Quanyin, Lv, Wei, Xu, Qunwei, Gu, Zhen, Xin, Hongliang

“…Ischemic stroke caused by a thrombus clog and ischemia is one of the most lethal and disabling cerebrovascular diseases. A sequentially targeted delivery…”
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Shape-controlled synthesis of liquid metal nanodroplets for photothermal therapy by Yan, Junjie, Zhang, Xudong, Liu, Yang, Ye, Yanqi, Yu, Jicheng, Chen, Qian, Wang, Jinqiang, Zhang, Yuqi, Hu, Quanyin, Kang, Yang, Yang, Min, Gu, Zhen

“…The capping agents for liquid metal (LM) nanodroplets in aqueous solutions are restricted to thiol-containing and positively-charged molecules or…”
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Light-Activated Hypoxia-Responsive Nanocarriers for Enhanced Anticancer Therapy by Qian, Chenggen, Yu, Jicheng, Chen, Yulei, Hu, Quanyin, Xiao, Xuanzhong, Sun, Wujin, Wang, Chao, Feng, Peijian, Shen, Qun-Dong, Gu, Zhen

“…A light‐activated hypoxia‐responsive conjugated polymer‐based nanocarrier is developed for efficiently producing singlet oxygen (1O2) and inducing hypoxia to…”
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Enhancing Gasdermin-induced tumor pyroptosis through preventing ESCRT-dependent cell membrane repair augments antitumor immune response by Li, Zhaoting, Mo, Fanyi, Wang, Yixin, Li, Wen, Chen, Yu, Liu, Jun, Chen-Mayfield, Ting-Jing, Hu, Quanyin

“…Pore-forming Gasdermin protein-induced pyroptosis in tumor cells promotes anti-tumor immune response through the release of pro-inflammatory cytokines and…”
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PD‐1 Blockade Cellular Vesicles for Cancer Immunotherapy by Zhang, Xudong, Wang, Chao, Wang, Jinqiang, Hu, Quanyin, Langworthy, Benjamin, Ye, Yanqi, Sun, Wujin, Lin, Jing, Wang, Tianfu, Fine, Jason, Cheng, Hao, Dotti, Gianpietro, Huang, Peng, Gu, Zhen

“…Cancer cells resist to the host immune antitumor response via multiple suppressive mechanisms, including the overexpression of PD‐L1 that exhausts…”
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Transformable liquid-metal nanomedicine by Lu, Yue, Hu, Quanyin, Lin, Yiliang, Pacardo, Dennis B., Wang, Chao, Sun, Wujin, Ligler, Frances S., Dickey, Michael D., Gu, Zhen

“…To date, numerous inorganic nanocarriers have been explored for drug delivery systems (DDSs). However, the clinical application of inorganic formulations has…”
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In situ activation of platelets with checkpoint inhibitors for post-surgical cancer immunotherapy by Wang, Chao, Sun, Wujin, Ye, Yanqi, Hu, Quanyin, Bomba, Hunter N., Gu, Zhen

“…Cancer recurrence after surgical resection remains a significant challenge in cancer therapy. Platelets, which accumulate in wound sites and interact with…”
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Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets by Hu, Quanyin, Li, Hongjun, Archibong, Edikan, Chen, Qian, Ruan, Huitong, Ahn, Sarah, Dukhovlinova, Elena, Kang, Yang, Wen, Di, Dotti, Gianpietro, Gu, Zhen

“…The immunosuppressive microenvironment of solid tumours reduces the antitumour activity of chimeric antigen receptor T cells (CAR-T cells). Here, we show that…”
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Chiral Supraparticles for Controllable Nanomedicine by Yeom, Jihyeon, Guimaraes, Pedro P. G., Ahn, Hyo Min, Jung, Bo‐Kyeong, Hu, Quanyin, McHugh, Kevin, Mitchell, Michael J., Yun, Chae‐Ok, Langer, Robert, Jaklenec, Ana

“…Chirality is ubiquitous in nature and hard‐wired into every biological system. Despite the prevalence of chirality in biological systems, controlling…”
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Convergence of nanomedicine and neutrophils for drug delivery by Yuan, Sichen, Hu, Quanyin

“…Neutrophils have recently emerged as promising carriers for drug delivery due to their unique properties including rapid response toward inflammation,…”
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Anaerobe‐Inspired Anticancer Nanovesicles by Qian, Chenggen, Feng, Peijian, Yu, Jicheng, Chen, Yulei, Hu, Quanyin, Sun, Wujin, Xiao, Xuanzhong, Hu, Xiuli, Bellotti, Adriano, Shen, Qun‐Dong, Gu, Zhen

“…Anaerobic bacteria, such as Clostridium and Salmonella, can selectively invade and colonize in tumor hypoxic regions (THRs) and deliver therapeutic products to…”
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Bio‐Orthogonal Chemistry in Cell Engineering by Wang, Yixin, Hu, Quanyin

“…Cell therapy holds great promise in addressing a wide range of malignant diseases, such as cancers and infectious diseases. The convergence of chemistry,…”
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Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy by Hu, Quanyin, Sun, Wujin, Wang, Jinqiang, Ruan, Huitong, Zhang, Xudong, Ye, Yanqi, Shen, Song, Wang, Chao, Lu, Weiyue, Cheng, Ke, Dotti, Gianpietro, Zeidner, Joshua F., Wang, Jun, Gu, Zhen

“…Patients with acute myeloid leukaemia who relapse following therapy have few treatment options and face poor outcomes. Immune checkpoint inhibition, for…”
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Dual targeted nanocarrier for brain ischemic stroke treatment by Zhao, Yue, Jiang, Yan, Lv, Wei, Wang, Zhongyuan, Lv, Lingyan, Wang, Baoyan, Liu, Xin, Liu, Yang, Hu, Quanyin, Sun, Wujin, Xu, Qunwei, Xin, Hongliang, Gu, Zhen

“…Focal cerebral ischemia, known as stroke, causes serious long-term disabilities globally. Effective therapy for cerebral ischemia demands a carrier that can…”
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