Search Results - "Hu, Qingzhong"

Cushing’s Syndrome: Development of Highly Potent and Selective CYP11B1 Inhibitors of the (Pyridylmethyl)pyridine Type by Emmerich, Juliette, Hu, Qingzhong, Hanke, Nina, Hartmann, Rolf W

“…Potent and selective CYP11B1 inhibitors could be promising therapeutics for the treatment of Cushing’s syndrome. Optimization of Ref 1…”
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3-Pyridyl substituted aliphatic cycles as CYP11B2 inhibitors: aromaticity abolishment of the core significantly increased selectivity over CYP1A2 by Yin, Lina, Hu, Qingzhong, Hartmann, Rolf W

“…Aldosterone synthase (CYP11B2) is a promising therapeutic target for the treatment of cardiovascular diseases related to abnormally high aldosterone levels. On…”
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Recent progress in pharmaceutical therapies for castration-resistant prostate cancer by Yin, Lina, Hu, Qingzhong, Hartmann, Rolf W

“…Since 2010, six drugs have been approved for the treatment of castration-resistant prostate cancer, i.e., CYP17 inhibitor Abiraterone, androgen receptor…”
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Highly Potent and Selective Nonsteroidal Dual Inhibitors of CYP17/CYP11B2 for the Treatment of Prostate Cancer To Reduce Risks of Cardiovascular Diseases by Pinto-Bazurco Mendieta, Mariano A. E, Hu, Qingzhong, Engel, Matthias, Hartmann, Rolf W

“…Dual CYP17/CYP11B2 inhibitors are proposed as a novel strategy for the treatment of prostate cancer to reduce risks of cardiovascular diseases. Via a…”
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Novel CYP17 inhibitors: Synthesis, biological evaluation, structure–activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls by Hille, Ulrike E., Hu, Qingzhong, Vock, Carsten, Negri, Matthias, Bartels, Marc, Müller-Vieira, Ursula, Lauterbach, Thomas, Hartmann, Rolf W.

“…Recently, the steroidal CYP17 inhibitor Abiraterone entered phase II clinical trial for the treatment of androgen-dependent prostate cancer. As…”
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Manipulations of phenylnorbornyl palladium species for multicomponent construction of a bridged polycyclic privileged scaffold by Yin, Lina, Guan, Ting, Cheng, Jie, Pan, Dongchao, Lu, Jinyang, Huang, Jiahui, Wu, Jiaqi, Chen, Xiaoli, You, Taiyun, Huo, Xuting, He, Yuting, Pang, Jiayun, Hu, Qingzhong

“…Hexahydromethanocarbazole is a privileged scaffold in the discovery of new drugs and photoactive organic materials due to its good balance between structural…”
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CYP17 inhibitors—abiraterone, C17,20-lyase inhibitors and multi-targeting agents by Yin, Lina, Hu, Qingzhong

“…Key Points 17α-Hydroxylase/C17,20-lyase (CYP17) is a steroidogenic enzyme that is central to the production of androgens, and is targeted by abiraterone in men…”
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Chimera induced protein degradation: PROTACs and beyond by Yin, Lina, Hu, Qingzhong

“…Ubiquitin–proteasome system, autophagy-lysosome pathway and N-end rule pathway are crucial protein quality control mechanisms in human body. Hijacking these…”
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Visible-Light-Promoted [4π + 2σ] Annulation of Dienes and Alkylamines via Dual Inert C(sp3)–H Bond Activation by Wang, Shuzhong, Zheng, Nuowen, Deji, Cuo, Hu, Qingzhong, Wu, Xinxin, Zhan, Ruoting, Huang, Huicai, Zhang, Yue

“…Herein, visible-light-promoted [4π + 2σ] annulation of dienes and alkylamines was achieved via dual C­(sp3)–H bond functionalization of alkylamines. The…”
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Natural products in pursuing novel therapies of nonalcoholic fatty liver disease and steatohepatitis by Li, Haiyan, Guan, Ting, Qin, Shi, Xu, Qihao, Yin, Lina, Hu, Qingzhong

“…•Many natural products ameliorate nonalcoholic fatty liver disease and nonalcoholic steatohepatitis via various mechanisms.•Alkaloids and terpenoids deserve…”
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Aldosterone synthase inhibitors as promising treatments for mineralocorticoid dependent cardiovascular and renal diseases by Hu, Qingzhong, Yin, Lina, Hartmann, Rolf W

“…Besides the well-known roles of aldosterone as a mineralocorticoid in regulating homeostasis of electrolytes and volume, recent studies revealed that it is…”
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Design, Synthesis, and Biological Evaluations of Pyridyl 4,5,6,7-Tetrahydro-4,7-Methanobenzo[d]isoxazoles as Potent and Selective Inhibitors of 11β-Hydroxylase by Yin, Lina, Pan, Youtian, Xue, Yuanyuan, Chen, Xiaoli, You, Taiyun, Huang, Jiahui, Xu, Qihao, Hu, Qingzhong

“…Inhibition of CYP11B1 is a promising therapy for severe diseases caused by excessive cortisol. Enantiomer discrimination provides clues to achieve selectivity…”
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Tetrahydropyrroloquinolinone Type Dual Inhibitors of Aromatase/Aldosterone Synthase as a Novel Strategy for Breast Cancer Patients with Elevated Cardiovascular Risks by Yin, Lina, Hu, Qingzhong, Hartmann, Rolf W

“…The application of aromatase inhibitors to postmenopausal breast cancer patients increases the risk of cardiovascular diseases (CVD), which is believed to be…”
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Selective Dual Inhibitors of CYP19 and CYP11B2: Targeting Cardiovascular Diseases Hiding in the Shadow of Breast Cancer by Hu, Qingzhong, Yin, Lina, Hartmann, Rolf W

“…Postmenopausal women are at high risk for cardiovascular diseases because of the estrogen deficiency. As for postmenopausal breast cancer patients, this risk…”
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Proposing anti‐counterfeiting pharmacopoeia quality markers for Shenlingbaizhu granule based on UHPLC‐Q‐orbitrap‐MS identification by Zeng, Jingyuan, Li, Xican, Cai, Rongxin, Chen, Ban, Li, Chunhou, Hu, Qingzhong, Sun, Yue

“…Introduction Shenlingbaizhu granule, a Traditional Chinese Medicine prescription comprising Renshen, Gancao, and Shanyao, is widely consumed in China nowadays…”
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Sinomenine Derivatives: Synthesis, Antitumor Activity, and Apoptotic Induction in MCF‐7 Cells via IL‐6/PI3K/Akt/NF‐κB Signaling Pathway by Zhu, Zuchang, Zhou, Huixian, Chen, Fenglian, Deng, Jianxiong, Yin, Lina, He, Baoen, Hu, Qingzhong, Wang, Tao

“…Natural products have been widely considered as an important resource for new drugs or lead compounds. Sinomenine (SIN) and its derivatives exert antitumor…”
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Fluorescence detecting glycopeptide antibiotics via a dynamic molecular switch by Zou, Xiaomei, Lin, Yanting, Zhang, Shihui, Deng, Tao, Xu, Ximing, Zhou, Yingchun, Liu, Zhihui, Lu, Weiguo, Hu, Qingzhong, Lin, Chaozhan, Zhu, Chenchen, Liu, Fang

“…Glycopeptide antibiotics (GPAs) represented by vancomycin (VAN) are clinically used as a first-line treatment for serious infections caused by Gram-positive…”
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Drug discovery for breast cancer and co-instantaneous cardiovascular disease: what is the future? by Yin, Lina, Hu, Qingzhong

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Therapeutic compounds for Cushing's syndrome: a patent review (2012-2016) by Ma, Li, Yin, Lina, Hu, Qingzhong

“…Endogenous Cushing's syndrome (CS) is a set of disorders caused by chronic exposure to excess glucocorticoids induced by neuroendocrine tumors in pituitary,…”
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Exploiting the Chromone Scaffold for the Development of Inhibitors of Corticosteroid Biosynthesis by Gobbi, Silvia, Hu, Qingzhong, Zimmer, Christina, Engel, Matthias, Belluti, Federica, Rampa, Angela, Hartmann, Rolf W, Bisi, Alessandra

“…The inhibition of corticosteroid biosynthesis could be considered as an emerging strategy to reduce their abnormally high levels, and in this framework CYP11B1…”
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