Search Results - "Hu, Li‐Fan"
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Pathologically Responsive Mitochondrial Gene Therapy in an Allotopic Expression‐Independent Manner Cures Leber's Hereditary Optic Neuropathy
Published in Advanced materials (Weinheim) (01-10-2021)“…Leber's hereditary optic neuropathy (LHON) is a rare inherited blindness caused by mutations in the mitochondrial DNA (mtDNA). The disorder is untreatable and…”
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Enhanced nuclear gene delivery via integrating and streamlining intracellular pathway
Published in Journal of controlled release (01-01-2022)“…The essential challenge of gene therapy is to develop safe and efficient vectors that escort genes to target sites. However, due to the cumbersome workflow of…”
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Gene therapy strategies for rare monogenic disorders with nuclear or mitochondrial gene mutations
Published in Biomaterials (01-10-2021)“…Rare monogenic disorders are a group of single-gene-mutated diseases that have a low incidence rate (less than 0.5‰) and eventually lead to patient disability…”
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Integrated mRNA-miRNA transcriptome profiling of blood immune responses potentially related to pulmonary fibrosis in forest musk deer
Published in Frontiers in immunology (30-05-2024)“…Forest musk deer (FMD, ) is a critically endangered species world-widely, the death of which can be caused by pulmonary disease in the farm. Pulmonary fibrosis…”
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Association factors of target organ damage: analysis of 17 682 elderly hypertensive patients in China
Published in Chinese medical journal (20-11-2011)“…Background Hypertensive target organ damage (TOD) is the main reason for mortality or disability in elderly hypertensive patients. The studies on TOD of…”
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Mitophagy-Enhanced Nanoparticle-Engineered Mitochondria Restore Homeostasis of Mitochondrial Pool for Alleviating Pulmonary Fibrosis
Published in ACS nano (26-11-2024)“…Pulmonary fibrosis (PF) is an interstitial lung disease tightly associated with the disruption of mitochondrial pool homeostasis, a delicate balance influenced…”
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Effect of lactoferrin- and transferrin-conjugated polymersomes in brain targeting: in vitro and in vivo evaluations
Published in Acta pharmacologica Sinica (01-02-2010)“…Aim: To evaluate the effect of lactoferrin (Lf) and transferrin (Tf) in brain targeting. Methods: Polymersomes (PSs), employed as vectors, were conjugated with…”
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The effect of inhibition of endoplasmic reticulum stress on lipolysis in white adipose tissue in a rat model of chronic kidney disease
Published in Acta pharmacologica Sinica (01-03-2014)“…Aim; Lipolysis in fat tissue plays an important role in the development of metabolic disturbances, a characteristic feature of chronic kidney disease (CKD). In…”
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9
he Natural Progression of Parkinson's Disease in a Small Cohort with 15 Drug-na'~'ve Patients
Published in 中华医学杂志:英文版 (2015)“…The studies of the natural progression of Parkinson's disease (PD) in Chinese populations have been lacking. To address this issue and obtain a preliminary…”
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On Design of Conjugated Transmission Scheme for FBMC/OQAM Systems with Interference Cancellation
Published in China communications (01-08-2017)“…Compared to OFDM systems with cyclic prefi x, fi lterbank multicarrier with offset quadrature amplitude modulation(FBMC/OQAM) system is considered as an…”
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Automatic recognition of loess landforms using Random Forest method
Published in Journal of mountain science (01-05-2017)“…The automatic recognition of landforms is regarded as one of the most important procedures to classify landforms and deepen the understanding on the morphology…”
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High prevalence of aspirin resistance in elderly patients with cardiovascular disease and metabolic syndrome
Published in Journal of geriatric cardiology : JGC (01-09-2016)“…Background Metabolic syndrome is known to be a prothrombotic state. We undertook this study to examine a hypothesis that aspirin resistance may be associated…”
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Establishing a predictive model for aspirin resistance in elderly Chinese patients with chronic cardiovascular disease
Published in Journal of geriatric cardiology : JGC (01-07-2016)“…Background Resistance to anti-platelet therapy is detrimental to patients. Our aim was to establish a predictive model for aspirin resistance to identify…”
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Automatic recognition of loess landforms using Random Forest method
Published in 山地科学学报:英文版 (2017)“…The automatic recognition of landforms is regarded as one of the most important procedures to classify landforms and deepen the understanding on the morphology…”
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Impact of agricultural intensification on soil organic carbon" A study using DNDC in Huantai County, Shandong Province, China
Published in Journal of Integrative Agriculture (01-06-2016)“…Using the biogeochemical model den itrification/decomposition (DN DC), the dynamic changes of soil organic carbon (SOC) of farmland from the 1980s to 2030s…”
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Determination of fenticonazole in human plasma by HPLC–MS/MS and its application to pharmacokinetic studies
Published in Journal of pharmaceutical analysis (01-02-2017)“…Two simple and sensitive high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) methods were developed and validated for the…”
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Evolution of the single-mode squeezed vacuum state in amplitude dissipative channel
Published in Frontiers of physics (01-02-2014)“…Using the way of deriving infinitive sum representation of density operator as a solution to the master equation describing the amplitude dissipative channel…”
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