Search Results - "Hu, Laixing"

Identification of small molecule compounds targeting the interaction of HIV-1 Vif and human APOBEC3G by virtual screening and biological evaluation by Ma, Ling, Zhang, Zhixin, Liu, Zhenlong, Pan, Qinghua, Wang, Jing, Li, Xiaoyu, Guo, Fei, Liang, Chen, Hu, Laixing, Zhou, Jinming, Cen, Shan

“…Human APOBEC3G (hA3G) is a restriction factor that inhibits human immunodeficiency 1 virus (HIV-1) replication. The virally encoded protein Vif binds to hA3G…”
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Optimization of the central linker of dicationic bis-benzimidazole anti-MRSA and anti-VRE agents by Hu, Laixing, Kully, Maureen L., Boykin, David W., Abood, Norman

“…A series of bis-benzimidazole diamidine compounds containing different central linkers has been synthesized and evaluated for in vitro antibacterial…”
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Structural Based Screening of Antiandrogen Targeting Activation Function-2 Binding Site by Liu, Yangguang, Wu, Meng, Wang, Tianqi, Xie, Yongli, Cui, Xiangling, He, Liujun, He, Yang, Li, Xiaoyu, Liu, Mingliang, Hu, Laixing, Cen, Shan, Zhou, Jinming

“…Androgen receptor (AR) plays a critical role in the development and progression of prostate cancer (PCa). Current antiandrogen therapies induce resistant…”
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Synthesis and Structure−Activity Relationships of Carbazole Sulfonamides as a Novel Class of Antimitotic Agents Against Solid Tumors by Hu, Laixing, Li, Zhuo-rong, Li, Yan, Qu, Jinrong, Ling, Yi-He, Jiang, Jian-dong, Boykin, David W

“…Two series of carbazole sulfonamides related to Combretastatin A4 (1) were synthesized and evaluated for antiproliferative activity. Thirteen of the 26 new…”
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Synthesis and structure–activity relationship of dicationic diaryl ethers as novel potent anti-MRSA and anti-VRE agents by Hu, Laixing, Kully, Maureen L., Boykin, David W., Abood, Norman

“…A series of dicationic diaryl ethers have been synthesized and evaluated for in vitro antibacterial activities, including drug resistant bacterial strains…”
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Synthesis and activity of azaterphenyl diamidines against Trypanosoma brucei rhodesiense and Plasmodium falciparum by Hu, Laixing, Arafa, Reem K., Ismail, Mohamed A., Patel, Alpa, Munde, Manoj, Wilson, W. David, Wenzler, Tanja, Brun, Reto, Boykin, David W.

“…A series of azaterphenyl diamidines has been synthesized and evaluated for in vitro antiprotozoal activity against both Trypanosoma brucei rhodesiense ( T. b…”
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Novel potent antimitotic heterocyclic ketones: Synthesis, antiproliferative activity, and structure–activity relationships by Hu, Laixing, Jiang, Jian-dong, Qu, Jinrong, Li, Yan, Jin, Jie, Li, Zhuo-rong, Boykin, David W.

“…We report the synthesis, antiproliferative activity, and SAR of novel heterocyclic ketones derived from carbazole sulfonamides. Most of the heterocyclic…”
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N-(2,6-Dimeth-oxy-pyridin-3-yl)-9-methyl-9H-carbazole-3-sulfonamide by Shan, Guangzhi, Li, Zhuorong, Hu, Laixing, Jiang, Jiandong, Liu, Zongying

“…In the title compound, C20H19N3O4S, a novel tubulin ligand active against human cancer, the dihedral angle between the pyridine ring and the carbazole ring…”
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Azaterphenyl diamidines as antileishmanial agents by Hu, Laixing, Arafa, Reem K., Ismail, Mohamed A., Wenzler, Tanja, Brun, Reto, Munde, Manoj, Wilson, W. David, Nzimiro, Sandra, Samyesudhas, Serene, Werbovetz, Karl A., Boykin, David W.

“…Eighteen diamidino azaterphenyls and analogues were evaluated as anti-leishmanials; nine of the compounds gave IC 50 values less than 1 μM, five exhibited…”
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Novel diaryl or heterocyclic sulfonamides as antimitotic agents by Hu, Laixing, Li, Zhuo-rong, Jiang, Jian-dong, Boykin, David W

“…The sulfonamides constitute an important class of drugs, which display a variety of activities including antibacterial, anti-carbonic anhydrase, diuretic,…”
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Synthesis of novel substituted N-aryl benzamides as hA3G stabilizers and their inhibitory activities against hepatitis C virus replication by Li, Yanping, Peng, Zonggen, Hao, Lanhu, Wu, Zhouyi, Zhu, Yanping, Hu, Laixing, Jiang, Jiandong, Li, Zhuorong

“…A series of novel amino-substituted N-aryl benzamide analogs were synthesized and evaluated for their ability to inhibit hepatitis C virus (HCV) replication in…”
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Synthesis and structure-activity relationship study of water-soluble carbazole sulfonamide derivatives as new anticancer agents by Liu, Yonghua, Wu, Yanbin, Sun, lianqi, Gu, Yuxi, Hu, Laixing

“…Here, we formulated and investigated the structure-activity relationships of novel N-substituted carbazole sulfonamide derivatives with improved…”
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3-(2′-Bromopropionylamino)-benzamides as novel S-phase arrest agents by Hu, Laixing, Li, Zhuo-rong, Li, Jian-Nong, Qu, Jinrong, Jiang, Jian-Dong, Boykin, David W.

“…We report the synthesis, antiproliferative activity, and SAR of novel 3-(2′-bromopropionylamino)-benzamides. Many of the benzamide compounds showed potent…”
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Novel pyridinyl and pyrimidinylcarbazole sulfonamides as antiproliferative agents by Hu, Laixing, Li, Zhuo-rong, Wang, Yue-ming, Wu, Yanbin, Jiang, Jian-Dong, Boykin, David W.

“…Carbazole sulfonamides II showed potent antiproliferative activity. A series of azaheterocyclic carbazole sulfonamides was synthesized and evaluated for…”
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Novel carbazole sulfonamide derivatives of antitumor agent: Synthesis, antiproliferative activity and aqueous solubility by Sun, Lianqi, Wu, Yanbin, Liu, Yonghua, Chen, Xiaofang, Hu, Laixing

“…The current optimization of IG-105 (3) on the carbazole-ring provided a series of new carbazole sulfonamides derivatives 13a–13m. Compounds 13f and 13i were…”
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Structure-activity relationship study of new carbazole sulfonamide derivatives as anticancer agents with dual-target mechanism by Liu, Yonghua, Zhang, Junyi, Tian, Jiaqi, Wang, Chengxi, Wang, Tianqi, Gong, Jianhua, Hu, Laixing

“…A series of novel carbazole sulfonamide derivatives were synthesized and evaluated for antiproliferative activity. Among them, compounds 7 and 15 showed strong…”
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Synthesis and structure-activity relationship study of new biaryl amide derivatives and their inhibitory effects against hepatitis C virus by Liu, Yonghua, Li, Jianrui, Gu, Yuxi, Ma, Ling, Cen, Shan, Peng, Zonggen, Hu, Laixing

“…A series of novel biaryl amide derivatives were synthesized and evaluated for anti-HCV virus activity. Some significant SARs were uncovered. The intensive…”
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Synthesis and structure-activity relationship of novel bisindole amidines active against MDR Gram-positive and Gram-negative bacteria by Liu, Yonghua, Hu, Xinxin, Wu, Yanbin, Zhang, Weixing, Chen, Xiaofang, You, Xuefu, Hu, Laixing

“…A series of novel diamidines with N-substituents on an amidine N-atom were synthesized and evaluated for their cytotoxicity and in vitro antibacterial activity…”
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Design, synthesis, and evaluations of the antiproliferative activity and aqueous solubility of novel carbazole sulfonamide derivatives as antitumor agents by Sun, Lianqi, Wang, Chenxi, Hu, Xinyue, Wu, Yanbin, Jiang, Zhi, Li, Zhuorong, Chen, Xiaofang, Hu, Laixing

“…Optimization of IG-105 (1) on the carbazole ring provided five series of new carbazole sulfonamides derivatives. All of the compounds showed moderate cytotoxic…”
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Synthesis and in vitro activity of asymmetric indole-based bisamidine compounds against Gram-positive and Gram-negative pathogens by Chen, Xiaofang, Liu, Yonghua, Wang, Chong, Hu, Xinxin, Wu, Yanbin, Zhang, Yongzhong, Bian, Cong, You, Xuefu, Hu, Laixing

“…[Display omitted] •The symmetry of the lead compound’s structure had a great influence on its activity.•Most compounds demonstrated powerful antibacterial…”
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