Search Results - "Hu, Kangrui"
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Multiomics Profiling Reveals Protective Function of Schisandra Lignans against Acetaminophen-Induced Hepatotoxicity
Published in Drug metabolism and disposition (01-10-2020)“…The action principles of traditional Chinese medicines (TCMs) feature multiactive components, multitarget sites, and weak combination with action targets. In…”
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Feasibility exploration of GSH in the treatment of acute hepatic encephalopathy from the aspects of pharmacokinetics, pharmacodynamics, and mechanism
Published in Frontiers in pharmacology (03-06-2024)“…Our previous study highlighted the therapeutic potential of glutathione (GSH), an intracellular thiol tripeptide ubiquitous in mammalian tissues, in mitigating…”
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Absolute quantitative analysis of endogenous neurotransmitters and amino acids by liquid chromatography-tandem mass spectrometry combined with multidimensional adsorption and collision energy defect
Published in Journal of Chromatography A (08-02-2021)“…•Multi-dimensional adsorption was firstly used to prepare endogenous substances.•“Collision Energy Defect (CED)” was firstly used to unify mass signal…”
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Global analysis of qualitative and quantitative metabolism of Notoginsenoside R1 in rat liver-brain-gut axis based on LC-IT-TOF/MS combing mMDF strategy
Published in Phytomedicine (Stuttgart) (01-09-2022)“…BACKGROUNDThe metabolism study of active components for traditional Chinese medicine (TCM) in target organs is conducive to clarify the authentic active…”
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Insights into the Authentic Active Ingredients and Action Sites of Oral Exogenous Glutathione in the Treatment of Ischemic Brain Injury Based on Pharmacokinetic-Pharmacodynamic Studies
Published in Drug metabolism and disposition (01-01-2020)“…Glutathione (GSH) has been reported to be closely related to various diseases of the central nervous system, yet its authentic active ingredients and action…”
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Regulation of histidine metabolism by Lactobacillus Reuteri mediates the pathogenesis and treatment of ischemic stroke
Published in Acta pharmaceutica Sinica. B (01-10-2024)Get full text
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Activated charcoal significantly improved the reliability of methods for quantitative analysis of endogenous substances in biological specimens: Glutathione and cysteine as cases
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15-09-2018)“…When developing a quantitative assay for exogenous or endogenous compounds, guidelines for method validation normally recommend that the biological specimens…”
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